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Laboratory evaluation of anemia.
West J Med 1987; 146(4):443-51WJ

Abstract

The laboratory evaluation of anemia begins with a complete blood count and reticulocyte count. The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis. Examination of the peripheral smear and a small number of specific tests confirm the diagnosis. The serum iron level, total iron-binding capacity, serum ferritin level and hemoglobin electrophoresis generally separate the microcytic anemias. The erythrocyte size-distribution width may be particularly helpful in distinguishing iron deficiency from thalassemia minor. Significant changes have occurred in the laboratory evaluation of macrocytic anemia, and a new syndrome of nitrous oxide-induced megaloblastosis and neurologic dysfunction has been recognized. A suggested approach to the hemolytic anemias includes using the micro-Coombs' test and ektacytometry. Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including normocytic megaloblastic anemia and the acquired immunodeficiency syndrome.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3577135

Citation

Wallerstein, R O.. "Laboratory Evaluation of Anemia." The Western Journal of Medicine, vol. 146, no. 4, 1987, pp. 443-51.
Wallerstein RO. Laboratory evaluation of anemia. West J Med. 1987;146(4):443-51.
Wallerstein, R. O. (1987). Laboratory evaluation of anemia. The Western Journal of Medicine, 146(4), pp. 443-51.
Wallerstein RO. Laboratory Evaluation of Anemia. West J Med. 1987;146(4):443-51. PubMed PMID: 3577135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laboratory evaluation of anemia. A1 - Wallerstein,R O,Jr PY - 1987/4/1/pubmed PY - 2001/3/28/medline PY - 1987/4/1/entrez SP - 443 EP - 51 JF - The Western journal of medicine JO - West. J. Med. VL - 146 IS - 4 N2 - The laboratory evaluation of anemia begins with a complete blood count and reticulocyte count. The anemia is then categorized as microcytic, macrocytic or normocytic, with or without reticulocytosis. Examination of the peripheral smear and a small number of specific tests confirm the diagnosis. The serum iron level, total iron-binding capacity, serum ferritin level and hemoglobin electrophoresis generally separate the microcytic anemias. The erythrocyte size-distribution width may be particularly helpful in distinguishing iron deficiency from thalassemia minor. Significant changes have occurred in the laboratory evaluation of macrocytic anemia, and a new syndrome of nitrous oxide-induced megaloblastosis and neurologic dysfunction has been recognized. A suggested approach to the hemolytic anemias includes using the micro-Coombs' test and ektacytometry. Finally, a number of causes have been identified for normocytic anemia without reticulocytosis, including normocytic megaloblastic anemia and the acquired immunodeficiency syndrome. SN - 0093-0415 UR - https://www.unboundmedicine.com/medline/citation/3577135/Laboratory_evaluation_of_anemia_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/3577135/ DB - PRIME DP - Unbound Medicine ER -