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Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game.
Front Psychol. 2022; 13:915265.FP

Abstract

Benzodiazepines and antidepressants have been shown to change responses to unfairness; however, the effects of their combined use on unfairness evaluation are unknown. This study examines the effects of concomitant benzodiazepines and antidepressants long-term use on the evaluation of fair and unfair offers. To analyze behavioral changes on responses to unfairness, we compared the performance of medicated participants and healthy controls in the Ultimatum Game (UG), both in the proposer and in the respondent role. The results showed that long-term psychotropic users had the worse economic strategy by accepting less offers than control subjects. However, in the proposer role, the unfair offers made by participants were similar between groups. The present results suggest that long-term use of psychotropic medication, specifically the combination of benzodiazepines and antidepressants, may increase the sensitivity to unfairness, resulting in higher rejection rates in conditions where this strategy is the most disadvantageous.

Authors+Show Affiliations

Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.Department of Psychology, Istanbul Sabahattin Zaim University, Istanbul, Turkey.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal. São João University Hospital Center, Porto, Portugal.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences, University of Porto, Porto, Portugal.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35814094

Citation

Fernandes, Carina, et al. "Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use On Social Decision-Making: Results From the Ultimatum Game." Frontiers in Psychology, vol. 13, 2022, p. 915265.
Fernandes C, Garcez H, Balaban S, et al. Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game. Front Psychol. 2022;13:915265.
Fernandes, C., Garcez, H., Balaban, S., Barbosa, F., Pereira, M. R., Silveira, C., Marques-Teixeira, J., & Gonçalves, A. R. (2022). Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game. Frontiers in Psychology, 13, 915265. https://doi.org/10.3389/fpsyg.2022.915265
Fernandes C, et al. Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use On Social Decision-Making: Results From the Ultimatum Game. Front Psychol. 2022;13:915265. PubMed PMID: 35814094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Concomitant Benzodiazepines and Antidepressants Long-Term Use on Social Decision-Making: Results From the Ultimatum Game. AU - Fernandes,Carina, AU - Garcez,Helena, AU - Balaban,Senanur, AU - Barbosa,Fernando, AU - Pereira,Mariana R, AU - Silveira,Celeste, AU - Marques-Teixeira,João, AU - Gonçalves,Ana R, Y1 - 2022/06/22/ PY - 2022/04/07/received PY - 2022/05/31/accepted PY - 2022/7/11/entrez PY - 2022/7/12/pubmed PY - 2022/7/12/medline KW - antidepressants KW - benzodiazepines KW - decision-making KW - social cognition KW - unfairness SP - 915265 EP - 915265 JF - Frontiers in psychology JO - Front Psychol VL - 13 N2 - Benzodiazepines and antidepressants have been shown to change responses to unfairness; however, the effects of their combined use on unfairness evaluation are unknown. This study examines the effects of concomitant benzodiazepines and antidepressants long-term use on the evaluation of fair and unfair offers. To analyze behavioral changes on responses to unfairness, we compared the performance of medicated participants and healthy controls in the Ultimatum Game (UG), both in the proposer and in the respondent role. The results showed that long-term psychotropic users had the worse economic strategy by accepting less offers than control subjects. However, in the proposer role, the unfair offers made by participants were similar between groups. The present results suggest that long-term use of psychotropic medication, specifically the combination of benzodiazepines and antidepressants, may increase the sensitivity to unfairness, resulting in higher rejection rates in conditions where this strategy is the most disadvantageous. SN - 1664-1078 UR - https://www.unboundmedicine.com/medline/citation/35814094/Effects_of_Concomitant_Benzodiazepines_and_Antidepressants_Long_Term_Use_on_Social_Decision_Making:_Results_From_the_Ultimatum_Game_ DB - PRIME DP - Unbound Medicine ER -
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