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[Quality evaluation methods and quality transfer law of Mori Cortex, fried Mori Cortex and its standard decoction].
Zhongguo Zhong Yao Za Zhi. 2022 Jun; 47(12):3251-3257.ZZ

Abstract

This study aims to establish a method for the component content determination and fingerprint evaluation of Mori Cortex, fried Mori Cortex and its standard decoction, and to reveal the quality transfer law among the three based on transfer rate, extraction rate, and fingerprint similarity.Fifteen representative batches of Mori Cortex decoction pieces were collected to prepare fried Mori Cortex and its standard decoction.UPLC-PDA was employed to establish the content determination method and fingerprint.The established UPLC method and fingerprint could be applied to the detection of Mori Cortex, fried Mori Cortex and its standard decoction.The UPLC fingerprints of the 15 batches of Mori Cortex and fried Mori Cortex had good similarity(>0.9) and the same common peaks.However, only one characteristic peak(mulberroside A) could be observed in the fingerprint of fried Mori Cortex standard decoction, which indicated that the corresponding components of other common peaks in the fingerprint of Mori Cortex had low content in the water extract.The extraction rates of mulberroside A from Mori Cortex, fried Mori Cortex and its standard decoction were 1.49%-2.00%, 1.62%-2.27% and 0.75%-1.29%, respectively.Mulberroside A showed the transfer rate of 103.7%-116.3% from Mori Cortex to fried Mori Cortex and 45.7%-56.9% from fried Mori Cortex to its standard decoction.The extraction rates of the 15 batches of fried Mori Cortex standard decoctions were 14.7%-19.5%.All the above indicators were within±30% of the mean value.This study established a method for the determination of mulberroside A content and fingerprint of Mori Cortex, fried Mori Cortex and its standard decoction, and clarified the quality transfer law among the three.It established the method for quality evaluation of Mori Cortex and fried Mori Cortex and can provide reference for the whole-process quality control in the preparation of the agents containing fried Mori Cortex.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hao LX
Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Jiao QS
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Qin XM
Modern Research Center for Traditional Chinese Medicine, Shanxi University Taiyuan 030006, China.
Dai YT
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
Shi ZX
Hubei Meisichuang Pharmaceutical Industry Co., Ltd. Xiangyang 434300, China.
Huang CC
Hubei Meisichuang Pharmaceutical Industry Co., Ltd. Xiangyang 434300, China.

MeSH

Chromatography, High Pressure LiquidDrugs, Chinese HerbalQuality Control

Pub Type(s)

Journal Article

Language

chi

PubMed ID

35851118

Citation

Hao, Li-Xia, et al. "[Quality Evaluation Methods and Quality Transfer Law of Mori Cortex, Fried Mori Cortex and Its Standard Decoction]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 47, no. 12, 2022, pp. 3251-3257.
Hao LX, Jiao QS, Qin XM, et al. [Quality evaluation methods and quality transfer law of Mori Cortex, fried Mori Cortex and its standard decoction]. Zhongguo Zhong Yao Za Zhi. 2022;47(12):3251-3257.
Hao, L. X., Jiao, Q. S., Qin, X. M., Dai, Y. T., Shi, Z. X., & Huang, C. C. (2022). [Quality evaluation methods and quality transfer law of Mori Cortex, fried Mori Cortex and its standard decoction]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 47(12), 3251-3257. https://doi.org/10.19540/j.cnki.cjcmm.20210804.302
Hao LX, et al. [Quality Evaluation Methods and Quality Transfer Law of Mori Cortex, Fried Mori Cortex and Its Standard Decoction]. Zhongguo Zhong Yao Za Zhi. 2022;47(12):3251-3257. PubMed PMID: 35851118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Quality evaluation methods and quality transfer law of Mori Cortex, fried Mori Cortex and its standard decoction]. AU - Hao,Li-Xia, AU - Jiao,Qi-Shu, AU - Qin,Xue-Mei, AU - Dai,Yun-Tao, AU - Shi,Zong-Xin, AU - Huang,Cheng-Cheng, PY - 2022/7/19/entrez PY - 2022/7/20/pubmed PY - 2022/7/22/medline KW - Mori Cortex KW - fingerprint KW - fried Mori Cortex KW - mulberroside A KW - quality transfer KW - standard decoction SP - 3251 EP - 3257 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 47 IS - 12 N2 - This study aims to establish a method for the component content determination and fingerprint evaluation of Mori Cortex, fried Mori Cortex and its standard decoction, and to reveal the quality transfer law among the three based on transfer rate, extraction rate, and fingerprint similarity.Fifteen representative batches of Mori Cortex decoction pieces were collected to prepare fried Mori Cortex and its standard decoction.UPLC-PDA was employed to establish the content determination method and fingerprint.The established UPLC method and fingerprint could be applied to the detection of Mori Cortex, fried Mori Cortex and its standard decoction.The UPLC fingerprints of the 15 batches of Mori Cortex and fried Mori Cortex had good similarity(>0.9) and the same common peaks.However, only one characteristic peak(mulberroside A) could be observed in the fingerprint of fried Mori Cortex standard decoction, which indicated that the corresponding components of other common peaks in the fingerprint of Mori Cortex had low content in the water extract.The extraction rates of mulberroside A from Mori Cortex, fried Mori Cortex and its standard decoction were 1.49%-2.00%, 1.62%-2.27% and 0.75%-1.29%, respectively.Mulberroside A showed the transfer rate of 103.7%-116.3% from Mori Cortex to fried Mori Cortex and 45.7%-56.9% from fried Mori Cortex to its standard decoction.The extraction rates of the 15 batches of fried Mori Cortex standard decoctions were 14.7%-19.5%.All the above indicators were within±30% of the mean value.This study established a method for the determination of mulberroside A content and fingerprint of Mori Cortex, fried Mori Cortex and its standard decoction, and clarified the quality transfer law among the three.It established the method for quality evaluation of Mori Cortex and fried Mori Cortex and can provide reference for the whole-process quality control in the preparation of the agents containing fried Mori Cortex. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/35851118/[Quality_evaluation_methods_and_quality_transfer_law_of_Mori_Cortex_fried_Mori_Cortex_and_its_standard_decoction]_ DB - PRIME DP - Unbound Medicine ER -