Tags

Type your tag names separated by a space and hit enter

[Hydrolyzable tannins from flowers of Punica granatum and their anti-diabetic activities].
Zhongguo Zhong Yao Za Zhi. 2022 Jun; 47(12):3258-3264.ZZ

Abstract

To investigate the active components against diabetes, the present study isolated eight hydrolyzable tannins from the ethyl acetate extract of Punica granatum flowers by MCI, reversed-phase chromatography(ODS), Sephadex LH-20 chromatography, and HPLC, and the structures were elucidated as 1-O-galloyl-6-O-feruloyl-β-D-glucose(1), 1,2,3,4,6-penta-O-gally-β-D-glucopyranose(2), punicafolin(3), corilagin(4), telimagrandin Ⅰ(5), 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-β-D-glucose(6), heterophylliin A(7), and eugeniin(8) on the basis of spectral data and literature records. Among them, compound 1 is a new compound, and compounds 5-8 were isolated from this species for the first time. All isolated compounds were tested for inhibitory activities against α-glucosidase and DPP-Ⅳ. The results indicated that compounds 2, 3, and 5-8 showed significant inhibitory activities against α-glucosidase, while compounds 1 and 4 exhibited moderate inhibitory activities. Compounds 5, 7, and 8 showed moderate inhibitory effects on DPP-Ⅳ. In addition, the type of enzyme inhibition of compound 5 was determined.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Yu YH
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China College of Life Sciences, Jiangxi Normal University Nanchang 330022, China.
Jia L
College of Life Sciences, Jiangxi Normal University Nanchang 330022, China.
Zeng HT
College of Life Sciences, Jiangxi Normal University Nanchang 330022, China.
Yuan T
Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences Urumqi 830011, China.

MeSH

Diabetes MellitusFlowersGlucoseHydrolyzable TanninsLythraceaePlant ExtractsPomegranatealpha-Glucosidases

Pub Type(s)

Journal Article

Language

chi

PubMed ID

35851119

Citation

Yu, Yi-Hu, et al. "[Hydrolyzable Tannins From Flowers of Punica Granatum and Their Anti-diabetic Activities]." Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, vol. 47, no. 12, 2022, pp. 3258-3264.
Yu YH, Jia L, Zeng HT, et al. [Hydrolyzable tannins from flowers of Punica granatum and their anti-diabetic activities]. Zhongguo Zhong Yao Za Zhi. 2022;47(12):3258-3264.
Yu, Y. H., Jia, L., Zeng, H. T., & Yuan, T. (2022). [Hydrolyzable tannins from flowers of Punica granatum and their anti-diabetic activities]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica, 47(12), 3258-3264. https://doi.org/10.19540/j.cnki.cjcmm.20220129.201
Yu YH, et al. [Hydrolyzable Tannins From Flowers of Punica Granatum and Their Anti-diabetic Activities]. Zhongguo Zhong Yao Za Zhi. 2022;47(12):3258-3264. PubMed PMID: 35851119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hydrolyzable tannins from flowers of Punica granatum and their anti-diabetic activities]. AU - Yu,Yi-Hu, AU - Jia,Li, AU - Zeng,Hui-Ting, AU - Yuan,Tao, PY - 2022/7/19/entrez PY - 2022/7/20/pubmed PY - 2022/7/22/medline KW - DPP-Ⅳ KW - Punica granatum flowers KW - anti-diabetes KW - bioactive components KW - α-glucosidase SP - 3258 EP - 3264 JF - Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica JO - Zhongguo Zhong Yao Za Zhi VL - 47 IS - 12 N2 - To investigate the active components against diabetes, the present study isolated eight hydrolyzable tannins from the ethyl acetate extract of Punica granatum flowers by MCI, reversed-phase chromatography(ODS), Sephadex LH-20 chromatography, and HPLC, and the structures were elucidated as 1-O-galloyl-6-O-feruloyl-β-D-glucose(1), 1,2,3,4,6-penta-O-gally-β-D-glucopyranose(2), punicafolin(3), corilagin(4), telimagrandin Ⅰ(5), 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-β-D-glucose(6), heterophylliin A(7), and eugeniin(8) on the basis of spectral data and literature records. Among them, compound 1 is a new compound, and compounds 5-8 were isolated from this species for the first time. All isolated compounds were tested for inhibitory activities against α-glucosidase and DPP-Ⅳ. The results indicated that compounds 2, 3, and 5-8 showed significant inhibitory activities against α-glucosidase, while compounds 1 and 4 exhibited moderate inhibitory activities. Compounds 5, 7, and 8 showed moderate inhibitory effects on DPP-Ⅳ. In addition, the type of enzyme inhibition of compound 5 was determined. SN - 1001-5302 UR - https://www.unboundmedicine.com/medline/citation/35851119/[Hydrolyzable_tannins_from_flowers_of_Punica_granatum_and_their_anti_diabetic_activities]_ DB - PRIME DP - Unbound Medicine ER -