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Scrub Typhus Associated with Guillain-Barré Syndrome (GBS).
Indian J Pediatr. 2022 11; 89(11):1129-1130.IJ

Abstract

Scrub typhus is a vector-borne disease caused by Orientia tsutsugamushi. Clinical manifestations generally occur due to vasculitis and inflammation and can have variable degrees of systemic involvement. Meningoencephalitis and cerebellitis are well-known neurological manifestations of scrub typhus, but the occurrence of Guillain-Barré syndrome is extremely rare. The authors report a 7-y-old boy who developed fever followed by rapidly progressive ascending quadriparesis with areflexia and whose etiological workup revealed positive IgM scrub typhus antibody, as well as, a high OXK titer (1:80). Nerve-conduction studies in all four limbs were suggestive of demyelinating neuropathy. He showed complete recovery after treatment with intravenous immunoglobulin (2 g/kg) and azithromycin.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Raghunathan V
Pediatric Intensive Care Unit, Medanta - The Medicity, Gurugram, Haryana, India.
Dhaliwal M
Pediatric Intensive Care Unit, Medanta - The Medicity, Gurugram, Haryana, India.
Singhi P
Pediatric Neurology, Medanta - The Medicity, Gurugram, Haryana, India.
Singhi S
Chair, Division of Pediatrics, Medanta - The Medicity, Gurugram, Haryana, 122001, India. sunitcsinghi@gmail.com.

MeSH

AzithromycinGuillain-Barre SyndromeHumansImmunoglobulin MImmunoglobulins, IntravenousMaleOrientia tsutsugamushiScrub Typhus

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35881216

Citation

Raghunathan, Veena, et al. "Scrub Typhus Associated With Guillain-Barré Syndrome (GBS)." Indian Journal of Pediatrics, vol. 89, no. 11, 2022, pp. 1129-1130.
Raghunathan V, Dhaliwal M, Singhi P, et al. Scrub Typhus Associated with Guillain-Barré Syndrome (GBS). Indian J Pediatr. 2022;89(11):1129-1130.
Raghunathan, V., Dhaliwal, M., Singhi, P., & Singhi, S. (2022). Scrub Typhus Associated with Guillain-Barré Syndrome (GBS). Indian Journal of Pediatrics, 89(11), 1129-1130. https://doi.org/10.1007/s12098-022-04312-y
Raghunathan V, et al. Scrub Typhus Associated With Guillain-Barré Syndrome (GBS). Indian J Pediatr. 2022;89(11):1129-1130. PubMed PMID: 35881216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Scrub Typhus Associated with Guillain-Barré Syndrome (GBS). AU - Raghunathan,Veena, AU - Dhaliwal,Maninder, AU - Singhi,Pratibha, AU - Singhi,Sunit, Y1 - 2022/07/26/ PY - 2022/02/08/received PY - 2022/06/10/accepted PY - 2022/7/27/pubmed PY - 2022/10/19/medline PY - 2022/7/26/entrez KW - Guillain–Barré syndrome KW - Pediatric KW - Scrub typhus SP - 1129 EP - 1130 JF - Indian journal of pediatrics JO - Indian J Pediatr VL - 89 IS - 11 N2 - Scrub typhus is a vector-borne disease caused by Orientia tsutsugamushi. Clinical manifestations generally occur due to vasculitis and inflammation and can have variable degrees of systemic involvement. Meningoencephalitis and cerebellitis are well-known neurological manifestations of scrub typhus, but the occurrence of Guillain-Barré syndrome is extremely rare. The authors report a 7-y-old boy who developed fever followed by rapidly progressive ascending quadriparesis with areflexia and whose etiological workup revealed positive IgM scrub typhus antibody, as well as, a high OXK titer (1:80). Nerve-conduction studies in all four limbs were suggestive of demyelinating neuropathy. He showed complete recovery after treatment with intravenous immunoglobulin (2 g/kg) and azithromycin. SN - 0973-7693 UR - https://www.unboundmedicine.com/medline/citation/35881216/Scrub_Typhus_Associated_with_Guillain_Barré_Syndrome__GBS__ DB - PRIME DP - Unbound Medicine ER -