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Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis.
Pharmaceuticals (Basel). 2022 Jul 19; 15(7)P

Abstract

The use of rocuronium/sugammadex in otorhinolaryngologic surgery improves intubation conditions and surgical rating scales. This study primarily aimed to evaluate the effect of the combination of rocuronium and sugammadex on intraoperative anesthetic consumption. The secondary outcomes were the intraoperative and postoperative morphine milligram equivalent (MME) consumption, duration of intraoperative hypertension, extubation time, incidence of delayed extubation and postoperative nausea and vomiting, pain score, and length of stay. A total of 2848 patients underwent otorhinolaryngologic surgery at a tertiary medical center in southern Taiwan. After applying the exclusion criteria, 2648 of these cases were included, with 167 and 2481 in the rocuronium/sugammadex and cisatracurium/neostigmine groups, respectively. To reduce potential bias, 119 patients in each group were matched by propensity scores for sex, age, body weight, and type of surgery. We found that the rocuronium/sugammadex group was associated with significant preservation of the intraoperative sevoflurane and MME consumption, with reductions of 14.2% (p = 0.009) and 11.8% (p = 0.035), respectively. The use of the combination of rocuronium and sugammadex also significantly increased the dose of intraoperative labetalol (p = 0.002), although there was no significant difference in intraoperative hypertensive events between both groups. In conclusion, our results may encourage the use of the combination of rocuronium and sugammadex as part of volatile-sparing and opioid-sparing anesthesia in otorhinolaryngologic surgery.

Authors+Show Affiliations

Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan.Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan.Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung City 833, Taiwan. Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan.Department of Anesthesiology, Jen-Ai Hospital, Taichung 412, Taiwan.Department of Anesthesiology, Park One International Hospital, No. 100, Bo'ai 2nd Rd., Zuoying Dist., Kaohsiung City 813, Taiwan.Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, No. 123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan.Division of Plastic and Reconstructive Surgery, Department of Surgery, Kaohsiung Chang Gung Memorial Hospital, College of Medicine, Chang Gung University, No. 123, Ta-Pei Rd., Niao-Song Dist., Kaohsiung City 833, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35890192

Citation

Wu, En-Bo, et al. "Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: a Propensity Score-Matched Analysis." Pharmaceuticals (Basel, Switzerland), vol. 15, no. 7, 2022.
Wu EB, Hung CT, Luo SD, et al. Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis. Pharmaceuticals (Basel). 2022;15(7).
Wu, E. B., Hung, C. T., Luo, S. D., Wu, S. C., Lee, T. Y., Chin, J. C., Tsai, P. N., & Yang, J. C. (2022). Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis. Pharmaceuticals (Basel, Switzerland), 15(7). https://doi.org/10.3390/ph15070894
Wu EB, et al. Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: a Propensity Score-Matched Analysis. Pharmaceuticals (Basel). 2022 Jul 19;15(7) PubMed PMID: 35890192.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic and Anesthetic Efficacy of Rocuronium/Sugammadex in Otorhinolaryngologic Surgery: A Propensity Score-Matched Analysis. AU - Wu,En-Bo, AU - Hung,Chao-Ting, AU - Luo,Sheng-Dean, AU - Wu,Shao-Chun, AU - Lee,Tsung-Yang, AU - Chin,Jo-Chi, AU - Tsai,Peng-Neng, AU - Yang,Johnson Chia-Shen, Y1 - 2022/07/19/ PY - 2022/06/01/received PY - 2022/07/01/revised PY - 2022/07/16/accepted PY - 2022/7/27/entrez PY - 2022/7/28/pubmed PY - 2022/7/28/medline KW - opioid-sparing anesthesia KW - otorhinolaryngologic surgery KW - propensity score analysis KW - sugammadex KW - volatile-sparing anesthesia JF - Pharmaceuticals (Basel, Switzerland) JO - Pharmaceuticals (Basel) VL - 15 IS - 7 N2 - The use of rocuronium/sugammadex in otorhinolaryngologic surgery improves intubation conditions and surgical rating scales. This study primarily aimed to evaluate the effect of the combination of rocuronium and sugammadex on intraoperative anesthetic consumption. The secondary outcomes were the intraoperative and postoperative morphine milligram equivalent (MME) consumption, duration of intraoperative hypertension, extubation time, incidence of delayed extubation and postoperative nausea and vomiting, pain score, and length of stay. A total of 2848 patients underwent otorhinolaryngologic surgery at a tertiary medical center in southern Taiwan. After applying the exclusion criteria, 2648 of these cases were included, with 167 and 2481 in the rocuronium/sugammadex and cisatracurium/neostigmine groups, respectively. To reduce potential bias, 119 patients in each group were matched by propensity scores for sex, age, body weight, and type of surgery. We found that the rocuronium/sugammadex group was associated with significant preservation of the intraoperative sevoflurane and MME consumption, with reductions of 14.2% (p = 0.009) and 11.8% (p = 0.035), respectively. The use of the combination of rocuronium and sugammadex also significantly increased the dose of intraoperative labetalol (p = 0.002), although there was no significant difference in intraoperative hypertensive events between both groups. In conclusion, our results may encourage the use of the combination of rocuronium and sugammadex as part of volatile-sparing and opioid-sparing anesthesia in otorhinolaryngologic surgery. SN - 1424-8247 UR - https://www.unboundmedicine.com/medline/citation/35890192/Analgesic_and_Anesthetic_Efficacy_of_Rocuronium/Sugammadex_in_Otorhinolaryngologic_Surgery:_A_Propensity_Score-Matched_Analysis. DB - PRIME DP - Unbound Medicine ER -
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