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Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects.
Thorax. 1986 Dec; 41(12):955-9.T

Abstract

The effect of a selective thromboxane synthetase inhibitor, OKY-046, and a selective 5-lipoxygenase inhibitor, AA-861, on bronchial responsiveness to acetylcholine was studied in 23 asthmatic subjects. The provocative concentration of acetylcholine producing a 20% fall in forced expiratory volume in one second (PC20 FEV1) was measured before and after oral administration of OKY-046 (3000 mg over four days) and AA-861 (1100 mg over four days) and inhalation of OKY-046 (30 mg) in 10, 10, and nine asthmatic subjects respectively. Baseline values of FEV1 and forced vital capacity (FVC) were not altered by oral OKY-046, oral AA-861, or inhaled OKY-046. The geometric mean value of PC20 FEV1 increased significantly from 0.55 to 2.24 mg/ml after oral OKY-046, but was unchanged after inhalation of OKY-046 and after oral administration of AA-861. These results suggest that thromboxane A2 may play a part in bronchial hyperresponsiveness to acetylcholine.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3590057

Citation

Fujimura, M, et al. "Effects of a Thromboxane Synthetase Inhibitor (OKY-046) and a Lipoxygenase Inhibitor (AA-861) On Bronchial Responsiveness to Acetylcholine in Asthmatic Subjects." Thorax, vol. 41, no. 12, 1986, pp. 955-9.
Fujimura M, Sasaki F, Nakatsumi Y, et al. Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax. 1986;41(12):955-9.
Fujimura, M., Sasaki, F., Nakatsumi, Y., Takahashi, Y., Hifumi, S., Taga, K., Mifune, J., Tanaka, T., & Matsuda, T. (1986). Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. Thorax, 41(12), 955-9.
Fujimura M, et al. Effects of a Thromboxane Synthetase Inhibitor (OKY-046) and a Lipoxygenase Inhibitor (AA-861) On Bronchial Responsiveness to Acetylcholine in Asthmatic Subjects. Thorax. 1986;41(12):955-9. PubMed PMID: 3590057.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of a thromboxane synthetase inhibitor (OKY-046) and a lipoxygenase inhibitor (AA-861) on bronchial responsiveness to acetylcholine in asthmatic subjects. AU - Fujimura,M, AU - Sasaki,F, AU - Nakatsumi,Y, AU - Takahashi,Y, AU - Hifumi,S, AU - Taga,K, AU - Mifune,J, AU - Tanaka,T, AU - Matsuda,T, PY - 1986/12/1/pubmed PY - 1986/12/1/medline PY - 1986/12/1/entrez SP - 955 EP - 9 JF - Thorax JO - Thorax VL - 41 IS - 12 N2 - The effect of a selective thromboxane synthetase inhibitor, OKY-046, and a selective 5-lipoxygenase inhibitor, AA-861, on bronchial responsiveness to acetylcholine was studied in 23 asthmatic subjects. The provocative concentration of acetylcholine producing a 20% fall in forced expiratory volume in one second (PC20 FEV1) was measured before and after oral administration of OKY-046 (3000 mg over four days) and AA-861 (1100 mg over four days) and inhalation of OKY-046 (30 mg) in 10, 10, and nine asthmatic subjects respectively. Baseline values of FEV1 and forced vital capacity (FVC) were not altered by oral OKY-046, oral AA-861, or inhaled OKY-046. The geometric mean value of PC20 FEV1 increased significantly from 0.55 to 2.24 mg/ml after oral OKY-046, but was unchanged after inhalation of OKY-046 and after oral administration of AA-861. These results suggest that thromboxane A2 may play a part in bronchial hyperresponsiveness to acetylcholine. SN - 0040-6376 UR - https://www.unboundmedicine.com/medline/citation/3590057/Effects_of_a_thromboxane_synthetase_inhibitor__OKY_046__and_a_lipoxygenase_inhibitor__AA_861__on_bronchial_responsiveness_to_acetylcholine_in_asthmatic_subjects_ L2 - http://thorax.bmj.com/cgi/pmidlookup?view=long&pmid=3590057 DB - PRIME DP - Unbound Medicine ER -