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A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders.
Mol Neurobiol. 2022 Oct; 59(10):6260-6280.MN

Abstract

Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies.

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Authors+Show Affiliations

Abdolahi S
Shefa Neuroscience Research Center, Khatam Alanbia Hospital, Tehran, Iran.
Zare-Chahoki A
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Noorbakhsh F
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Gorji A
Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. gorjial@uni-muenster.de. Department of Neurosurgery, Westfälische Wilhelms-Universität, Münster, Germany. gorjial@uni-muenster.de. Department of Neurology and Institute for Translational Neurology, Westfälische Wilhelms-Universität, Münster, Germany. gorjial@uni-muenster.de. Epilepsy Research Center, Westfälische Wilhelms-Universität, 48149, Münster, Germany. gorjial@uni-muenster.de.

MeSH

Alzheimer DiseaseBrain-Derived Neurotrophic FactorEpilepsyHumansMicroRNAsNeuronal PlasticitySignal Transduction

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

35916975

Citation

Abdolahi, Sara, et al. "A Review of Molecular Interplay Between Neurotrophins and miRNAs in Neuropsychological Disorders." Molecular Neurobiology, vol. 59, no. 10, 2022, pp. 6260-6280.
Abdolahi S, Zare-Chahoki A, Noorbakhsh F, et al. A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders. Mol Neurobiol. 2022;59(10):6260-6280.
Abdolahi, S., Zare-Chahoki, A., Noorbakhsh, F., & Gorji, A. (2022). A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders. Molecular Neurobiology, 59(10), 6260-6280. https://doi.org/10.1007/s12035-022-02966-5
Abdolahi S, et al. A Review of Molecular Interplay Between Neurotrophins and miRNAs in Neuropsychological Disorders. Mol Neurobiol. 2022;59(10):6260-6280. PubMed PMID: 35916975.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Review of Molecular Interplay between Neurotrophins and miRNAs in Neuropsychological Disorders. AU - Abdolahi,Sara, AU - Zare-Chahoki,Ameneh, AU - Noorbakhsh,Farshid, AU - Gorji,Ali, Y1 - 2022/08/02/ PY - 2022/03/21/received PY - 2022/07/17/accepted PY - 2022/8/3/pubmed PY - 2022/9/14/medline PY - 2022/8/2/entrez KW - BDNF KW - Brain KW - CNS KW - NT3 KW - Neurotrophic Factors KW - Psychological Disorders SP - 6260 EP - 6280 JF - Molecular neurobiology JO - Mol Neurobiol VL - 59 IS - 10 N2 - Various neurotrophins (NTs), including nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4, promote cellular differentiation, survival, and maintenance, as well as synaptic plasticity, in the peripheral and central nervous system. The function of microRNAs (miRNAs) and other small non-coding RNAs, as regulators of gene expression, is pivotal for the appropriate control of cell growth and differentiation. There are positive and negative loops between NTs and miRNAs, which exert modulatory effects on different signaling pathways. The interplay between NTs and miRNAs plays a crucial role in the regulation of several physiological and pathological brain procedures. Emerging evidence suggests the diagnostic and therapeutic roles of the interactions between NTs and miRNAs in several neuropsychological disorders, including epilepsy, multiple sclerosis, Alzheimer's disease, Huntington's disease, amyotrophic lateral sclerosis, schizophrenia, anxiety disorders, depression, post-traumatic stress disorder, bipolar disorder, and drug abuse. Here, we review current data regarding the regulatory interactions between NTs and miRNAs in neuropsychological disorders, for which novel diagnostic and/or therapeutic strategies are emerging. Targeting NTs-miRNAs interactions for diagnostic or therapeutic approaches needs to be validated by future clinical studies. SN - 1559-1182 UR - https://www.unboundmedicine.com/medline/citation/35916975/A_Review_of_Molecular_Interplay_between_Neurotrophins_and_miRNAs_in_Neuropsychological_Disorders_ DB - PRIME DP - Unbound Medicine ER -