Tags

Type your tag names separated by a space and hit enter

Protein balance during very-low-calorie diets for the treatment of severe obesity.
Ann Nutr Metab. 1987; 31(3):154-9.AN

Abstract

Very-low-calorie diets (less than 500 kcal/day; VLCD) are widely used for the treatment of severe obesity. We report the effects of such diets, consisting of proteins only or proteins and carbohydrates (CH), on nitrogen balance and protein nutritional status of morbidly obese patients. Cumulative nitrogen loss, serum albumin, transferrin, prealbumin (PA) and retinol-binding protein (RBP) concentrations, and plasma amino acid profile were determined in two groups of obese patients: 5 subjects (3 women, 2 men: BMI 55.3 +/- 2.2 kg/m2) subjected for 4 weeks to a protein VLCD (40 g protein + 2 g fat) and 7 others (4 women, 3 men: BMI 45.6 +/- 2.8 kg/m2) received for the same length of time a protein + CH VLCD (34 g protein + 26 g CH). Nitrogen balance was determined weekly whilst plasma and serum variables were measured on days 0, 3, 5, 10, 20 and 28 of treatment. Nitrogen balance did not significantly differ between the two groups of patients throughout the treatment. Serum PA and RBP concentrations decreased from day 5 and day 10, respectively, in both groups. Plasma amino acids showed a similar pattern in the protein and protein + CH groups. Alanine gradually decreased below baseline values; after a peak value on day 5, branched-chain amino acids (valine, leucine, isoleucine) returned to baseline values in both groups. In conclusion, in severely obese patients subjected to VLCD, nitrogen balance, labile protein concentrations and plasma amino acid profile are not significantly affected by adding CH to proteins.

Authors

Scalfi L
No affiliation info available
Contaldo F
No affiliation info available
Borrelli R
No affiliation info available
De Caterina M
No affiliation info available
Spagnuolo G
No affiliation info available
Alfieri R
No affiliation info available
Mancini M
No affiliation info available

MeSH

AdultAmino AcidsBlood ProteinsDiet, ReducingDietary CarbohydratesDietary ProteinsEnergy IntakeFemaleHumansMaleNitrogenObesityProteins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3592620

Citation

Scalfi, L, et al. "Protein Balance During Very-low-calorie Diets for the Treatment of Severe Obesity." Annals of Nutrition & Metabolism, vol. 31, no. 3, 1987, pp. 154-9.
Scalfi L, Contaldo F, Borrelli R, et al. Protein balance during very-low-calorie diets for the treatment of severe obesity. Ann Nutr Metab. 1987;31(3):154-9.
Scalfi, L., Contaldo, F., Borrelli, R., De Caterina, M., Spagnuolo, G., Alfieri, R., & Mancini, M. (1987). Protein balance during very-low-calorie diets for the treatment of severe obesity. Annals of Nutrition & Metabolism, 31(3), 154-9.
Scalfi L, et al. Protein Balance During Very-low-calorie Diets for the Treatment of Severe Obesity. Ann Nutr Metab. 1987;31(3):154-9. PubMed PMID: 3592620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protein balance during very-low-calorie diets for the treatment of severe obesity. AU - Scalfi,L, AU - Contaldo,F, AU - Borrelli,R, AU - De Caterina,M, AU - Spagnuolo,G, AU - Alfieri,R, AU - Mancini,M, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 154 EP - 9 JF - Annals of nutrition & metabolism JO - Ann Nutr Metab VL - 31 IS - 3 N2 - Very-low-calorie diets (less than 500 kcal/day; VLCD) are widely used for the treatment of severe obesity. We report the effects of such diets, consisting of proteins only or proteins and carbohydrates (CH), on nitrogen balance and protein nutritional status of morbidly obese patients. Cumulative nitrogen loss, serum albumin, transferrin, prealbumin (PA) and retinol-binding protein (RBP) concentrations, and plasma amino acid profile were determined in two groups of obese patients: 5 subjects (3 women, 2 men: BMI 55.3 +/- 2.2 kg/m2) subjected for 4 weeks to a protein VLCD (40 g protein + 2 g fat) and 7 others (4 women, 3 men: BMI 45.6 +/- 2.8 kg/m2) received for the same length of time a protein + CH VLCD (34 g protein + 26 g CH). Nitrogen balance was determined weekly whilst plasma and serum variables were measured on days 0, 3, 5, 10, 20 and 28 of treatment. Nitrogen balance did not significantly differ between the two groups of patients throughout the treatment. Serum PA and RBP concentrations decreased from day 5 and day 10, respectively, in both groups. Plasma amino acids showed a similar pattern in the protein and protein + CH groups. Alanine gradually decreased below baseline values; after a peak value on day 5, branched-chain amino acids (valine, leucine, isoleucine) returned to baseline values in both groups. In conclusion, in severely obese patients subjected to VLCD, nitrogen balance, labile protein concentrations and plasma amino acid profile are not significantly affected by adding CH to proteins. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/3592620/Protein_balance_during_very_low_calorie_diets_for_the_treatment_of_severe_obesity_ DB - PRIME DP - Unbound Medicine ER -