Tags

Type your tag names separated by a space and hit enter

Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variants.
J Med Virol. 2022 12; 94(12):6065-6072.JM

Abstract

Various variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of coronavirus disease-2019 efficiently. Here, we assess the immune responses of individuals after two shots of BBIBP-CorV or CoronaVac inactivated vaccine. We measured neutralizing antibody responses after the second vaccination by using authentic SARS-CoV-2 and its viral variants. All the serum samples efficiently neutralized SARS-CoV-2 wild-type lineage, in contrast, a part of serum samples failed to neutralize Alpha, Beta, Gamma, Delta, or Eta lineages, and only several serum samples were able to neutralize Omicron lineage virus strains (BA.1 and BA.2) with low neutralization titer. As compared with the neutralization of SARS-CoV-2 wild-type lineage, the neutralization of all other SARS-CoV-2 variant lineages was significantly lower. Considering that all the SARS-CoV-2 mutation viruses challenged the antibody neutralization induced by BBIBP-CorV and CoronaVac, it is necessary to carry out a third booster vaccination to increase the humoral immune response against the SARS-CoV-2 mutation viruses.

Links

Authors+Show Affiliations

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

BSL-3 Laboratory (Guangdong), Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, China.

Institute of Microbiology, Guangdong Provincial Center for Disease Control and Prevention, Guangdong, China.

MeSH

Antibodies, NeutralizingAntibodies, ViralCOVID-19COVID-19 VaccinesHumansSARS-CoV-2Vaccines, InactivatedViral Vaccines

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35931461

Citation

Zou, Lirong, et al. "Serosurvey in SARS-CoV-2 Inactivated Vaccine-elicited Neutralizing Antibodies Against Authentic SARS-CoV-2 and Its Viral Variants." Journal of Medical Virology, vol. 94, no. 12, 2022, pp. 6065-6072.

Zou L, Zhang H, Zheng Z, et al. Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variants. J Med Virol. 2022;94(12):6065-6072.

Zou, L., Zhang, H., Zheng, Z., Jiang, Y., Huang, Y., Lin, S., Yu, J., Deng, X., He, J., Shen, C., & Li, B. (2022). Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variants. Journal of Medical Virology, 94(12), 6065-6072. https://doi.org/10.1002/jmv.28049

Zou L, et al. Serosurvey in SARS-CoV-2 Inactivated Vaccine-elicited Neutralizing Antibodies Against Authentic SARS-CoV-2 and Its Viral Variants. J Med Virol. 2022;94(12):6065-6072. PubMed PMID: 35931461.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Serosurvey in SARS-CoV-2 inactivated vaccine-elicited neutralizing antibodies against authentic SARS-CoV-2 and its viral variants. AU - Zou,Lirong, AU - Zhang,Huan, AU - Zheng,Zhonghua, AU - Jiang,Yushan, AU - Huang,Yushi, AU - Lin,Shujian, AU - Yu,Jianxiang, AU - Deng,Xiaoling, AU - He,Jianfeng, AU - Shen,Chenguang, AU - Li,Baisheng, Y1 - 2022/08/15/ PY - 2022/07/07/revised PY - 2022/06/06/received PY - 2022/08/02/accepted PY - 2022/8/6/pubmed PY - 2022/10/18/medline PY - 2022/8/5/entrez KW - SARS-CoV-2 KW - immune response KW - inactivated vaccine KW - neutralizing antibodies KW - viral variants SP - 6065 EP - 6072 JF - Journal of medical virology JO - J Med Virol VL - 94 IS - 12 N2 - Various variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been emerging and circulating in different parts of the world. Millions of vaccine doses have been administered globally, which reduces the morbidity and mortality of coronavirus disease-2019 efficiently. Here, we assess the immune responses of individuals after two shots of BBIBP-CorV or CoronaVac inactivated vaccine. We measured neutralizing antibody responses after the second vaccination by using authentic SARS-CoV-2 and its viral variants. All the serum samples efficiently neutralized SARS-CoV-2 wild-type lineage, in contrast, a part of serum samples failed to neutralize Alpha, Beta, Gamma, Delta, or Eta lineages, and only several serum samples were able to neutralize Omicron lineage virus strains (BA.1 and BA.2) with low neutralization titer. As compared with the neutralization of SARS-CoV-2 wild-type lineage, the neutralization of all other SARS-CoV-2 variant lineages was significantly lower. Considering that all the SARS-CoV-2 mutation viruses challenged the antibody neutralization induced by BBIBP-CorV and CoronaVac, it is necessary to carry out a third booster vaccination to increase the humoral immune response against the SARS-CoV-2 mutation viruses. SN - 1096-9071 UR - https://www.unboundmedicine.com/medline/citation/35931461/Serosurvey_in_SARS_CoV_2_inactivated_vaccine_elicited_neutralizing_antibodies_against_authentic_SARS_CoV_2_and_its_viral_variants_ DB - PRIME DP - Unbound Medicine ER -