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Effects of oxiracetam on learning and memory in animals: comparison with piracetam.
Clin Neuropharmacol. 1986; 9 Suppl 3:S27-38.CN

Abstract

The effects of oxiracetam and piracetam were compared in learning and memory tests in rats and mice. In the dose range examined, the two nootropics were equally active in reducing the amnesia induced by cerebral electroshock in the mouse. Step-down retention performance, however, was distinctly improved by oxiracetam but unaffected by piracetam, no matter whether it was given before or immediately after the learning trial. Oxiracetam also improved acquisition performance in aged (24- to 27-month-old) rats in an active-avoidance situation at doses of 30 and 100 mg/kg i.p. whereas piracetam showed no effect at 100 mg/kg i.p.

Authors

Mondadori C
No affiliation info available
Classen W
No affiliation info available
Borkowski J
No affiliation info available
Ducret T
No affiliation info available
Buerki H
No affiliation info available
Schadé A
No affiliation info available

MeSH

AgingAnimalsAvoidance LearningDrug Administration ScheduleElectroshockMemoryMicePiracetamPyrrolidinesPyrrolidinonesRats

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

3594453

Citation

Mondadori, C, et al. "Effects of Oxiracetam On Learning and Memory in Animals: Comparison With Piracetam." Clinical Neuropharmacology, vol. 9 Suppl 3, 1986, pp. S27-38.
Mondadori C, Classen W, Borkowski J, et al. Effects of oxiracetam on learning and memory in animals: comparison with piracetam. Clin Neuropharmacol. 1986;9 Suppl 3:S27-38.
Mondadori, C., Classen, W., Borkowski, J., Ducret, T., Buerki, H., & Schadé, A. (1986). Effects of oxiracetam on learning and memory in animals: comparison with piracetam. Clinical Neuropharmacology, 9 Suppl 3, S27-38.
Mondadori C, et al. Effects of Oxiracetam On Learning and Memory in Animals: Comparison With Piracetam. Clin Neuropharmacol. 1986;9 Suppl 3:S27-38. PubMed PMID: 3594453.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oxiracetam on learning and memory in animals: comparison with piracetam. AU - Mondadori,C, AU - Classen,W, AU - Borkowski,J, AU - Ducret,T, AU - Buerki,H, AU - Schadé,A, PY - 1986/1/1/pubmed PY - 1986/1/1/medline PY - 1986/1/1/entrez SP - S27 EP - 38 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 9 Suppl 3 N2 - The effects of oxiracetam and piracetam were compared in learning and memory tests in rats and mice. In the dose range examined, the two nootropics were equally active in reducing the amnesia induced by cerebral electroshock in the mouse. Step-down retention performance, however, was distinctly improved by oxiracetam but unaffected by piracetam, no matter whether it was given before or immediately after the learning trial. Oxiracetam also improved acquisition performance in aged (24- to 27-month-old) rats in an active-avoidance situation at doses of 30 and 100 mg/kg i.p. whereas piracetam showed no effect at 100 mg/kg i.p. SN - 0362-5664 UR - https://www.unboundmedicine.com/medline/citation/3594453/Effects_of_oxiracetam_on_learning_and_memory_in_animals:_comparison_with_piracetam_ DB - PRIME DP - Unbound Medicine ER -