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Time-sensitive prefrontal involvement in associating confidence with task performance illustrates metacognitive introspection in monkeys.
Commun Biol. 2022 08 09; 5(1):799.CB

Abstract

Metacognition refers to the ability to be aware of one's own cognition. Ample evidence indicates that metacognition in the human primate is highly dissociable from cognition, specialized across domains, and subserved by distinct neural substrates. However, these aspects remain relatively understudied in macaque monkeys. In the present study, we investigated the functionality of macaque metacognition by combining a confidence proxy, hierarchical Bayesian meta-d' computational modelling, and a single-pulse transcranial magnetic stimulation technique. We found that Brodmann area 46d (BA46d) played a critical role in supporting metacognition independent of task performance; we also found that the critical role of this region in meta-calculation was time-sensitive. Additionally, we report that macaque metacognition is highly domain-specific with respect to memory and perception decisions. These findings carry implications for our understanding of metacognitive introspection within the primate lineage.

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Authors+Show Affiliations

Cai Y
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China. Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, 215316, China. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Jin Z
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China. Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, 215316, China. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China.
Zhai C
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China.
Wang H
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China. NYU-ECNU Institute of Brain and Cognitive Science at NYU Shanghai, Shanghai, 200062, China. Shanghai Changning Mental Health Center, Shanghai, 200335, China.
Wang J
Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, 200030, China. CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, 200031, China. Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China.
Tang Y
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, China. yytang0522@gmail.com.
Kwok SC
Shanghai Key Laboratory of Brain Functional Genomics, Key Laboratory of Brain Functional Genomics Ministry of Education, Shanghai Key Laboratory of Magnetic Resonance, Affiliated Mental Health Center (ECNU), School of Psychology and Cognitive Science, East China Normal University, Shanghai, 200062, China. sze-chai.kwok@st-hughs.oxon.org. Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, 215316, China. sze-chai.kwok@st-hughs.oxon.org. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, 100875, China. sze-chai.kwok@st-hughs.oxon.org. Shanghai Changning Mental Health Center, Shanghai, 200335, China. sze-chai.kwok@st-hughs.oxon.org.

MeSH

AnimalsBayes TheoremCognitionHaplorhiniHumansMetacognitionTask Performance and Analysis

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

35945257

Citation

Cai, Yudian, et al. "Time-sensitive Prefrontal Involvement in Associating Confidence With Task Performance Illustrates Metacognitive Introspection in Monkeys." Communications Biology, vol. 5, no. 1, 2022, p. 799.
Cai Y, Jin Z, Zhai C, et al. Time-sensitive prefrontal involvement in associating confidence with task performance illustrates metacognitive introspection in monkeys. Commun Biol. 2022;5(1):799.
Cai, Y., Jin, Z., Zhai, C., Wang, H., Wang, J., Tang, Y., & Kwok, S. C. (2022). Time-sensitive prefrontal involvement in associating confidence with task performance illustrates metacognitive introspection in monkeys. Communications Biology, 5(1), 799. https://doi.org/10.1038/s42003-022-03762-6
Cai Y, et al. Time-sensitive Prefrontal Involvement in Associating Confidence With Task Performance Illustrates Metacognitive Introspection in Monkeys. Commun Biol. 2022 08 9;5(1):799. PubMed PMID: 35945257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Time-sensitive prefrontal involvement in associating confidence with task performance illustrates metacognitive introspection in monkeys. AU - Cai,Yudian, AU - Jin,Zhiyong, AU - Zhai,Chenxi, AU - Wang,Huimin, AU - Wang,Jijun, AU - Tang,Yingying, AU - Kwok,Sze Chai, Y1 - 2022/08/09/ PY - 2021/12/29/received PY - 2022/07/22/accepted PY - 2022/8/9/entrez PY - 2022/8/10/pubmed PY - 2022/8/12/medline SP - 799 EP - 799 JF - Communications biology JO - Commun Biol VL - 5 IS - 1 N2 - Metacognition refers to the ability to be aware of one's own cognition. Ample evidence indicates that metacognition in the human primate is highly dissociable from cognition, specialized across domains, and subserved by distinct neural substrates. However, these aspects remain relatively understudied in macaque monkeys. In the present study, we investigated the functionality of macaque metacognition by combining a confidence proxy, hierarchical Bayesian meta-d' computational modelling, and a single-pulse transcranial magnetic stimulation technique. We found that Brodmann area 46d (BA46d) played a critical role in supporting metacognition independent of task performance; we also found that the critical role of this region in meta-calculation was time-sensitive. Additionally, we report that macaque metacognition is highly domain-specific with respect to memory and perception decisions. These findings carry implications for our understanding of metacognitive introspection within the primate lineage. SN - 2399-3642 UR - https://www.unboundmedicine.com/medline/citation/35945257/Time_sensitive_prefrontal_involvement_in_associating_confidence_with_task_performance_illustrates_metacognitive_introspection_in_monkeys_ DB - PRIME DP - Unbound Medicine ER -