TY - JOUR T1 - Persistent Hiccups Induced by Supratentorial Infarcts and Successful Treatment With a Combination of Perampanel and Baclofen: A Case Report. AU - Morita,Kohei, AU - Nuki,Yoshitsugu, AU - Hashizume,Hiroya, AU - Togo,Masaya, Y1 - 2022/08/03/ PY - 2022/8/11/pubmed PY - 2022/9/28/medline PY - 2022/8/10/entrez SP - 135 EP - 138 JF - Clinical neuropharmacology JO - Clin Neuropharmacol VL - 45 IS - 5 N2 - CASE: A 52-year-old man developed a cerebral infarction from the right middle cerebral artery occlusion, and the infarction extensively damaged the right insula. Three months after the onset of the cerebral infarction, persistent hiccups appeared, occurring during sleep. The thoracic and abdominal cavities showed no lesions; hence, the hiccups were considered to be caused by central nervous system dysfunction. Administration of metoclopramide, chlorpromazine, and diazepam were ineffective, while levetiracetam had a partial effect. Combining perampanel with baclofen finally suppressed the symptoms. DISCUSSION: Lesions at the right insula impair respiratory reflex and may present with hiccups as a symptom of respiratory reflex disinhibition. Here, we review similar cases of treatment-resistant hiccups, as well as perampanel and baclofen efficacy in myoclonus cases. CONCLUSIONS: Our patient's case suggested that perampanel with baclofen may be effective for myoclonus due to respiratory reflex disinhibition and can be used to treat hiccups derived from cerebral infarctions. SN - 1537-162X UR - https://www.unboundmedicine.com/medline/citation/35947416/Persistent_Hiccups_Induced_by_Supratentorial_Infarcts_and_Successful_Treatment_With_a_Combination_of_Perampanel_and_Baclofen:_A_Case_Report_ DB - PRIME DP - Unbound Medicine ER -