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The importance of precise plane selection for female adult Chiari Type I malformation midsagittal morphometrics.
PLoS One. 2022; 17(8):e0272725.Plos

Abstract

INTRODUCTION

Morphometric assessment of Chiari malformation type I (CMI) is typically performed on a midsagittal MRI. However, errors arising from an imprecise selection of the midsagittal plane are unknown. We define absolute parasagittal error as the absolute difference between morphometric measurements at the midsagittal and parasagittal planes. Our objective was to determine the absolute parasagittal error at various lateral distances for morphometric parameters commonly used in CMI research.

METHODS

Sagittal T1-weighted MRI scans of 30 CMI adult female subjects were included. Image sets were evaluated to assess 14 CMI morphometric parameters in the midsagittal plane and four parasagittal planes located 1 and 2 mm lateral (left and right). Comparisons between measurements at the midsagittal and parasagittal planes were conducted to determine the mean individual absolute and mean group parasagittal errors for all 14 parameters.

RESULTS

The mean individual absolute parasagittal error was > 1 unit (1 mm for lengths and 1 degree for angles) for 9/14 parameters within a lateral distance of 2 mm. No significant group parasagittal errors were seen in 14/14 parameters, including tonsillar position within a lateral distance of 2 mm.

CONCLUSION

Our results show that the absolute errors for imprecise midsagittal plane selection may impact the clinical assessment of an individual patient. However, the impact on group measurements, such as in a research setting, will be minimal.

Authors+Show Affiliations

Conquer Chiari Research Center, Department of Biomedical Engineering, The University of Akron, Akron, OH, United States of America.Conquer Chiari Research Center, Department of Biomedical Engineering, The University of Akron, Akron, OH, United States of America.Conquer Chiari Research Center, Department of Biomedical Engineering, The University of Akron, Akron, OH, United States of America.Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, United States of America.Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, United States of America.Conquer Chiari Research Center, Department of Psychology, The University of Akron, Akron, OH, United States of America.Conquer Chiari Research Center, Department of Psychology, The University of Akron, Akron, OH, United States of America.Departments of Mechanical and Industrial Engineering and Bioengineering, Northeastern University, Boston, MA, United States of America.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

35947605

Citation

Morkos, Mark, et al. "The Importance of Precise Plane Selection for Female Adult Chiari Type I Malformation Midsagittal Morphometrics." PloS One, vol. 17, no. 8, 2022, pp. e0272725.
Morkos M, Eppelheimer M, Nwotchouang BST, et al. The importance of precise plane selection for female adult Chiari Type I malformation midsagittal morphometrics. PLoS One. 2022;17(8):e0272725.
Morkos, M., Eppelheimer, M., Nwotchouang, B. S. T., Ebrahimzadeh, S. A., Bhadelia, R. A., Loth, D., Allen, P. A., & Loth, F. (2022). The importance of precise plane selection for female adult Chiari Type I malformation midsagittal morphometrics. PloS One, 17(8), e0272725. https://doi.org/10.1371/journal.pone.0272725
Morkos M, et al. The Importance of Precise Plane Selection for Female Adult Chiari Type I Malformation Midsagittal Morphometrics. PLoS One. 2022;17(8):e0272725. PubMed PMID: 35947605.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The importance of precise plane selection for female adult Chiari Type I malformation midsagittal morphometrics. AU - Morkos,Mark, AU - Eppelheimer,Maggie, AU - Nwotchouang,Blaise Simplice Talla, AU - Ebrahimzadeh,Seyed Amir, AU - Bhadelia,Rafeeque A, AU - Loth,Dorothy, AU - Allen,Philip A, AU - Loth,Francis, Y1 - 2022/08/10/ PY - 2022/04/05/received PY - 2022/07/25/accepted PY - 2022/8/10/entrez PY - 2022/8/11/pubmed PY - 2022/8/13/medline SP - e0272725 EP - e0272725 JF - PloS one JO - PLoS One VL - 17 IS - 8 N2 - INTRODUCTION: Morphometric assessment of Chiari malformation type I (CMI) is typically performed on a midsagittal MRI. However, errors arising from an imprecise selection of the midsagittal plane are unknown. We define absolute parasagittal error as the absolute difference between morphometric measurements at the midsagittal and parasagittal planes. Our objective was to determine the absolute parasagittal error at various lateral distances for morphometric parameters commonly used in CMI research. METHODS: Sagittal T1-weighted MRI scans of 30 CMI adult female subjects were included. Image sets were evaluated to assess 14 CMI morphometric parameters in the midsagittal plane and four parasagittal planes located 1 and 2 mm lateral (left and right). Comparisons between measurements at the midsagittal and parasagittal planes were conducted to determine the mean individual absolute and mean group parasagittal errors for all 14 parameters. RESULTS: The mean individual absolute parasagittal error was > 1 unit (1 mm for lengths and 1 degree for angles) for 9/14 parameters within a lateral distance of 2 mm. No significant group parasagittal errors were seen in 14/14 parameters, including tonsillar position within a lateral distance of 2 mm. CONCLUSION: Our results show that the absolute errors for imprecise midsagittal plane selection may impact the clinical assessment of an individual patient. However, the impact on group measurements, such as in a research setting, will be minimal. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/35947605/The_importance_of_precise_plane_selection_for_female_adult_Chiari_Type_I_malformation_midsagittal_morphometrics_ L2 - https://dx.plos.org/10.1371/journal.pone.0272725 DB - PRIME DP - Unbound Medicine ER -