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[Diabetic coma and Wernicke-Korsakoff syndrome. On the clinical significance of acquired thiamine deficiency].
Fortschr Neurol Psychiatr. 1987 Apr; 55(4):130-9.FN

Abstract

Following consideration of the nosological role of hyperglycemic states in psychiatry the case report of a fifty-five year-old patient is presented suffering from fatty cell degeneration of the liver and a relapsing pancreatitis due to chronic alcoholism. After a long period of abstinence without previously known diabetes mellitus a sudden ketoacidotic coma developed with maximum serum glucose level of 2020 mg%. Having emerged during coma treatment Wernicke's encephalopathy passed into Korsakoff's syndrome the main features of which remained unchanged for more than one year. In this case thiamine deficiency of different pathogenetical origin is discussed: defective exogeneous availability due to malabsorption; depletion of endogeneous thiamine stores due to enlarged requirements for glucose oxidation during coma therapy; antimetabolic effects to thiamine by nitroimidazole-derivatives administered parenterally.

Authors

Vieregge P
No affiliation info available
Stuhlmann W
No affiliation info available

MeSH

Alcohol Amnestic DisorderBlood GlucoseChronic DiseaseDiabetic ComaElectroencephalographyFatty Liver, AlcoholicHumansMaleMiddle AgedNeuropsychological TestsPancreatitisThiamine DeficiencyTomography, X-Ray ComputedWernicke Encephalopathy

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

ger

PubMed ID

3596452

Citation

Vieregge, P, and W Stuhlmann. "[Diabetic Coma and Wernicke-Korsakoff Syndrome. On the Clinical Significance of Acquired Thiamine Deficiency]." Fortschritte Der Neurologie-Psychiatrie, vol. 55, no. 4, 1987, pp. 130-9.
Vieregge P, Stuhlmann W. [Diabetic coma and Wernicke-Korsakoff syndrome. On the clinical significance of acquired thiamine deficiency]. Fortschr Neurol Psychiatr. 1987;55(4):130-9.
Vieregge, P., & Stuhlmann, W. (1987). [Diabetic coma and Wernicke-Korsakoff syndrome. On the clinical significance of acquired thiamine deficiency]. Fortschritte Der Neurologie-Psychiatrie, 55(4), 130-9.
Vieregge P, Stuhlmann W. [Diabetic Coma and Wernicke-Korsakoff Syndrome. On the Clinical Significance of Acquired Thiamine Deficiency]. Fortschr Neurol Psychiatr. 1987;55(4):130-9. PubMed PMID: 3596452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Diabetic coma and Wernicke-Korsakoff syndrome. On the clinical significance of acquired thiamine deficiency]. AU - Vieregge,P, AU - Stuhlmann,W, PY - 1987/4/1/pubmed PY - 1987/4/1/medline PY - 1987/4/1/entrez SP - 130 EP - 9 JF - Fortschritte der Neurologie-Psychiatrie JO - Fortschr Neurol Psychiatr VL - 55 IS - 4 N2 - Following consideration of the nosological role of hyperglycemic states in psychiatry the case report of a fifty-five year-old patient is presented suffering from fatty cell degeneration of the liver and a relapsing pancreatitis due to chronic alcoholism. After a long period of abstinence without previously known diabetes mellitus a sudden ketoacidotic coma developed with maximum serum glucose level of 2020 mg%. Having emerged during coma treatment Wernicke's encephalopathy passed into Korsakoff's syndrome the main features of which remained unchanged for more than one year. In this case thiamine deficiency of different pathogenetical origin is discussed: defective exogeneous availability due to malabsorption; depletion of endogeneous thiamine stores due to enlarged requirements for glucose oxidation during coma therapy; antimetabolic effects to thiamine by nitroimidazole-derivatives administered parenterally. SN - 0720-4299 UR - https://www.unboundmedicine.com/medline/citation/3596452/[Diabetic_coma_and_Wernicke_Korsakoff_syndrome__On_the_clinical_significance_of_acquired_thiamine_deficiency]_ DB - PRIME DP - Unbound Medicine ER -