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Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function.
Int J Clin Pharmacol Res. 1987; 7(4):291-9.IJ

Abstract

In a double-blind study the effect of a high dosage of O-(beta-hydroxyethyl)-rutosides (HR) was tested in women taking oral contraceptives and suffering from venous insufficiency of the lower limbs. Ten patients were treated for 28 days with HR (3 g/day) and ten with a placebo. In basal conditions and after therapy, the symptoms of venous disorders and the venous function, by means of strain gauge plethysmography, was evaluated in both groups. The results showed an increase of venous capacitance and a reduction of venous tone in the subjects treated including those without symptoms in the lower limbs. The HR treatment resulted in a significant improvement of the venous function parameters and of the symptoms in lower limbs.

Authors

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Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article

Language

eng

PubMed ID

3596872

Citation

Cappelli, R, et al. "Efficacy of O-(beta-hydroxyethyl)-rutosides at High Dosage in Counteracting the Unwanted Activity of Oral Contraceptives On Venous Function." International Journal of Clinical Pharmacology Research, vol. 7, no. 4, 1987, pp. 291-9.
Cappelli R, Pecchi S, Oberhauser V, et al. Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function. Int J Clin Pharmacol Res. 1987;7(4):291-9.
Cappelli, R., Pecchi, S., Oberhauser, V., Forconi, S., & Di Perri, T. (1987). Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function. International Journal of Clinical Pharmacology Research, 7(4), 291-9.
Cappelli R, et al. Efficacy of O-(beta-hydroxyethyl)-rutosides at High Dosage in Counteracting the Unwanted Activity of Oral Contraceptives On Venous Function. Int J Clin Pharmacol Res. 1987;7(4):291-9. PubMed PMID: 3596872.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of O-(beta-hydroxyethyl)-rutosides at high dosage in counteracting the unwanted activity of oral contraceptives on venous function. AU - Cappelli,R, AU - Pecchi,S, AU - Oberhauser,V, AU - Forconi,S, AU - Di Perri,T, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez KW - Chronic Diseases KW - Clinical Research KW - Contraception KW - Contraceptive Methods KW - Developed Countries KW - Diseases KW - Drugs KW - Europe KW - Examinations And Diagnoses KW - Family Planning KW - Human Volunteers KW - Ingredients And Chemicals KW - Italy KW - Laboratory Examinations And Diagnoses KW - Mediterranean Countries KW - Oral Contraceptives KW - Organic Chemicals KW - Research Methodology KW - Southern Europe KW - Treatment KW - Vascular Diseases KW - Venous Engorgement SP - 291 EP - 9 JF - International journal of clinical pharmacology research JO - Int J Clin Pharmacol Res VL - 7 IS - 4 N2 - In a double-blind study the effect of a high dosage of O-(beta-hydroxyethyl)-rutosides (HR) was tested in women taking oral contraceptives and suffering from venous insufficiency of the lower limbs. Ten patients were treated for 28 days with HR (3 g/day) and ten with a placebo. In basal conditions and after therapy, the symptoms of venous disorders and the venous function, by means of strain gauge plethysmography, was evaluated in both groups. The results showed an increase of venous capacitance and a reduction of venous tone in the subjects treated including those without symptoms in the lower limbs. The HR treatment resulted in a significant improvement of the venous function parameters and of the symptoms in lower limbs. SN - 0251-1649 UR - https://www.unboundmedicine.com/medline/citation/3596872/Efficacy_of_O__beta_hydroxyethyl__rutosides_at_high_dosage_in_counteracting_the_unwanted_activity_of_oral_contraceptives_on_venous_function_ DB - PRIME DP - Unbound Medicine ER -