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Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial.
Patient Saf Surg. 2022 Aug 19; 16(1):27.PS

Abstract

BACKGROUND

Maintenance of adequate peripheral perfusion during controlled hypotension is necessary for patient safety and improved surgical outcomes during controlled hypotension in nasal surgery. The hypothesis of this study was to investigate the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in patients undergoing nasal surgery.

METHODS

A total of 50 patients were randomly assigned into two equal groups in this double-blind clinical study: the magnesium sulfate group; received 40 mg/kg loading dose of intravenous (IV) magnesium sulfate followed by 10-15 mg/kg/h continuous IV infusion and the labetalol group; received 0.25 mg/kg loading dose of IV labetalol followed by 0.5-1 mg/kg/h continuous IV infusion to achieve a mean arterial blood pressure (MABP) of = 55-65 mmHg. The primary outcome was to compare the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion during nasal surgery. The secondary outcomes were the assessment of serum lactate, postoperative pain, time to the first call for pethidine (rescue analgesic) and total pethidine consumption.

RESULTS

PPI was comparable between the groups at baseline, intubation, and 5 min. In contrast, magnesium sulfate group had a significantly higher PPI than the labetalol group. The magnesium sulfate group had a significantly higher MABP and heart rate compared to labetalol group. The time to reach the target MABP was significantly prolonged in magnesium sulfate than the labetalol group [21.6 ± 1.7 vs 6.9 ± 1.5] min. VAS scores were significantly lower for 2 hs postoperatively in the magnesium sulfate group than the labetalol group. The time to first call of pethidine was significantly prolonged in the magnesium sulfate group compared to the labetalol group [113.1 ± 5.2 vs 28.2 ± 1.5] min.

CONCLUSIONS

Magnesium sulfate maintains wider PPI and offers better postoperative pain relief compared to labetalol during induced hypotension in nasal surgery.

TRIAL REGISTRATION

Institutional review board approval (ref: 6601/20-12-2020).

CLINICALTRIAL

gov (ref: NCT04688203 , date of registration: 29 -12-2020).

Authors+Show Affiliations

Anesthesia, Intensive Care and Pain Management Department, Faculty of Human Medicine, Zagazig University, Alsharkia, Egypt. eaKamil@zu.edu.eg.Anesthesia, Intensive Care and Pain Management Department, Faculty of Human Medicine, Zagazig University, Alsharkia, Egypt.Anesthesia, Intensive Care and Pain Management Department, Faculty of Human Medicine, Zagazig University, Alsharkia, Egypt.Anesthesia, Intensive Care and Pain Management Department, Faculty of Human Medicine, Zagazig University, Alsharkia, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

35986325

Citation

Kamel, Alshaimaa Abdel Fattah, et al. "Effect of Perioperative Magnesium Sulfate and Labetalol Infusion On Peripheral Perfusion and Postoperative Pain in Nasal Surgery: a Randomized Controlled Trial." Patient Safety in Surgery, vol. 16, no. 1, 2022, p. 27.
Kamel AAF, Medhat MM, Salem DAE, et al. Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial. Patient Saf Surg. 2022;16(1):27.
Kamel, A. A. F., Medhat, M. M., Salem, D. A. E., & Naby, S. M. A. (2022). Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial. Patient Safety in Surgery, 16(1), 27. https://doi.org/10.1186/s13037-022-00336-7
Kamel AAF, et al. Effect of Perioperative Magnesium Sulfate and Labetalol Infusion On Peripheral Perfusion and Postoperative Pain in Nasal Surgery: a Randomized Controlled Trial. Patient Saf Surg. 2022 Aug 19;16(1):27. PubMed PMID: 35986325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in nasal surgery: a randomized controlled trial. AU - Kamel,Alshaimaa Abdel Fattah, AU - Medhat,Marwa Mohamed, AU - Salem,Dina Abdelhameed Elsadek, AU - Naby,Sara Mohamed Abdel, Y1 - 2022/08/19/ PY - 2022/07/13/received PY - 2022/08/06/accepted PY - 2022/8/19/entrez PY - 2022/8/20/pubmed PY - 2022/8/20/medline KW - Induced hypotension KW - Labetalol KW - Magnesium sulfate KW - Nasal surgery KW - Peripheral perfusion index KW - Postoperative Pain SP - 27 EP - 27 JF - Patient safety in surgery JO - Patient Saf Surg VL - 16 IS - 1 N2 - BACKGROUND: Maintenance of adequate peripheral perfusion during controlled hypotension is necessary for patient safety and improved surgical outcomes during controlled hypotension in nasal surgery. The hypothesis of this study was to investigate the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion and postoperative pain in patients undergoing nasal surgery. METHODS: A total of 50 patients were randomly assigned into two equal groups in this double-blind clinical study: the magnesium sulfate group; received 40 mg/kg loading dose of intravenous (IV) magnesium sulfate followed by 10-15 mg/kg/h continuous IV infusion and the labetalol group; received 0.25 mg/kg loading dose of IV labetalol followed by 0.5-1 mg/kg/h continuous IV infusion to achieve a mean arterial blood pressure (MABP) of = 55-65 mmHg. The primary outcome was to compare the effect of perioperative magnesium sulfate and labetalol infusion on peripheral perfusion during nasal surgery. The secondary outcomes were the assessment of serum lactate, postoperative pain, time to the first call for pethidine (rescue analgesic) and total pethidine consumption. RESULTS: PPI was comparable between the groups at baseline, intubation, and 5 min. In contrast, magnesium sulfate group had a significantly higher PPI than the labetalol group. The magnesium sulfate group had a significantly higher MABP and heart rate compared to labetalol group. The time to reach the target MABP was significantly prolonged in magnesium sulfate than the labetalol group [21.6 ± 1.7 vs 6.9 ± 1.5] min. VAS scores were significantly lower for 2 hs postoperatively in the magnesium sulfate group than the labetalol group. The time to first call of pethidine was significantly prolonged in the magnesium sulfate group compared to the labetalol group [113.1 ± 5.2 vs 28.2 ± 1.5] min. CONCLUSIONS: Magnesium sulfate maintains wider PPI and offers better postoperative pain relief compared to labetalol during induced hypotension in nasal surgery. TRIAL REGISTRATION: Institutional review board approval (ref: 6601/20-12-2020). CLINICALTRIAL: gov (ref: NCT04688203 , date of registration: 29 -12-2020). SN - 1754-9493 UR - https://www.unboundmedicine.com/medline/citation/35986325/Effect_of_perioperative_magnesium_sulfate_and_labetalol_infusion_on_peripheral_perfusion_and_postoperative_pain_in_nasal_surgery:_a_randomized_controlled_trial. DB - PRIME DP - Unbound Medicine ER -
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