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Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials.
Pharmacol Res. 2022 10; 184:106399.PR

Abstract

Probiotics and synbiotics have been proposed to exhibit an important role in glucose homeostasis and maintain the balance of the gut microbiota. However, clinical trials have shown mixed findings. Therefore, we conducted a systematic review and meta-analysis of all eligible randomized controlled trials (RCTs) examining the effects of probiotics and synbiotics intake on glycemic outcomes among individuals with prediabetes and type 2 diabetes mellitus (T2DM). The PubMed/Medline, Scopus, ISI Web of Science, and Cochrane library were searched up to March 2022 for published RCTs exploring the effectiveness of probiotics and synbiotics compared to control on glycemic outcomes. The random-effects model was applied in order to the estimation of 95 % confidence interval (CI) and the weighted mean difference (WMD) for each endpoint. Meta-analysis of forty-six RCTs (3067 participants) showed that probiotics and synbiotics supplementation significantly reduced fasting plasma glucose (FPG) (weighted mean difference (WMD): - 11.18 mg/dl, 95 % CI: - 13.60, - 8.75, p ˂0.001), fasting insulin serum level (WMD: -1.23 µIU/ml, 95 % CI: -1.76, -0.71, p ˂0.001), hemoglobin A1c (HbA1c) (WMD: -0.35 %, 95 % CI: -0.44, -0.26, p˂0.001), and homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -0.87, 95 % CI: -1.09, -0.65, p˂0.001). Additionally, probiotics and synbiotics intake resulted in an increase in values of quantitative insulin-sensitivity check index (QUICKI) (WMD: 0.01, 95 % CI: 0.00, 0.01, p˂0.001). However, probiotics and synbiotics consumption did not change glucose values following oral glucose tolerance test (OGTT). Our findings suggest that probiotic and synbiotic intake has favorable effects on glycemic profile in patients with prediabetes and T2DM.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Naseri K
Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Saadati S
Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia.
Ashtary-Larky D
Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Asbaghi O
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ghaemi F
Department of Microbiology, Kerman Branch, Islamic Azad University, Kerman, Iran.
Pashayee-Khamene F
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Yari Z
Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
de Courten B
Department of Medicine, School of Clinical Sciences, Monash University, Melbourne, Australia; School of Health and Biomedical Sciences, RMIT University, Bundoora, Australia. Electronic address: barbora.decourten@monash.edu.

MeSH

Blood GlucoseDiabetes Mellitus, Type 2Dietary SupplementsGlycated HemoglobinGlycemic ControlHumansInsulin ResistanceInsulinsPrediabetic StateProbioticsRandomized Controlled Trials as TopicSynbiotics

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

35987483

Citation

Naseri, Kaveh, et al. "Probiotics and Synbiotics Supplementation Improve Glycemic Control Parameters in Subjects With Prediabetes and Type 2 Diabetes Mellitus: a GRADE-assessed Systematic Review, Meta-analysis, and Meta-regression of Randomized Clinical Trials." Pharmacological Research, vol. 184, 2022, p. 106399.
Naseri K, Saadati S, Ashtary-Larky D, et al. Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Pharmacol Res. 2022;184:106399.
Naseri, K., Saadati, S., Ashtary-Larky, D., Asbaghi, O., Ghaemi, F., Pashayee-Khamene, F., Yari, Z., & de Courten, B. (2022). Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. Pharmacological Research, 184, 106399. https://doi.org/10.1016/j.phrs.2022.106399
Naseri K, et al. Probiotics and Synbiotics Supplementation Improve Glycemic Control Parameters in Subjects With Prediabetes and Type 2 Diabetes Mellitus: a GRADE-assessed Systematic Review, Meta-analysis, and Meta-regression of Randomized Clinical Trials. Pharmacol Res. 2022;184:106399. PubMed PMID: 35987483.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotics and synbiotics supplementation improve glycemic control parameters in subjects with prediabetes and type 2 diabetes mellitus: A GRADE-assessed systematic review, meta-analysis, and meta-regression of randomized clinical trials. AU - Naseri,Kaveh, AU - Saadati,Saeede, AU - Ashtary-Larky,Damoon, AU - Asbaghi,Omid, AU - Ghaemi,Farahnaz, AU - Pashayee-Khamene,Fereshteh, AU - Yari,Zahra, AU - de Courten,Barbora, Y1 - 2022/08/18/ PY - 2022/06/19/received PY - 2022/08/14/revised PY - 2022/08/14/accepted PY - 2022/8/21/pubmed PY - 2022/10/18/medline PY - 2022/8/20/entrez KW - Diabetes mellitus KW - Glycemic profile KW - Meta-analysis KW - Prediabetes KW - Probiotic KW - Synbiotic SP - 106399 EP - 106399 JF - Pharmacological research JO - Pharmacol Res VL - 184 N2 - Probiotics and synbiotics have been proposed to exhibit an important role in glucose homeostasis and maintain the balance of the gut microbiota. However, clinical trials have shown mixed findings. Therefore, we conducted a systematic review and meta-analysis of all eligible randomized controlled trials (RCTs) examining the effects of probiotics and synbiotics intake on glycemic outcomes among individuals with prediabetes and type 2 diabetes mellitus (T2DM). The PubMed/Medline, Scopus, ISI Web of Science, and Cochrane library were searched up to March 2022 for published RCTs exploring the effectiveness of probiotics and synbiotics compared to control on glycemic outcomes. The random-effects model was applied in order to the estimation of 95 % confidence interval (CI) and the weighted mean difference (WMD) for each endpoint. Meta-analysis of forty-six RCTs (3067 participants) showed that probiotics and synbiotics supplementation significantly reduced fasting plasma glucose (FPG) (weighted mean difference (WMD): - 11.18 mg/dl, 95 % CI: - 13.60, - 8.75, p ˂0.001), fasting insulin serum level (WMD: -1.23 µIU/ml, 95 % CI: -1.76, -0.71, p ˂0.001), hemoglobin A1c (HbA1c) (WMD: -0.35 %, 95 % CI: -0.44, -0.26, p˂0.001), and homeostatic model assessment of insulin resistance (HOMA-IR) (WMD: -0.87, 95 % CI: -1.09, -0.65, p˂0.001). Additionally, probiotics and synbiotics intake resulted in an increase in values of quantitative insulin-sensitivity check index (QUICKI) (WMD: 0.01, 95 % CI: 0.00, 0.01, p˂0.001). However, probiotics and synbiotics consumption did not change glucose values following oral glucose tolerance test (OGTT). Our findings suggest that probiotic and synbiotic intake has favorable effects on glycemic profile in patients with prediabetes and T2DM. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/35987483/Probiotics_and_synbiotics_supplementation_improve_glycemic_control_parameters_in_subjects_with_prediabetes_and_type_2_diabetes_mellitus:_A_GRADE_assessed_systematic_review_meta_analysis_and_meta_regression_of_randomized_clinical_trials_ DB - PRIME DP - Unbound Medicine ER -