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Release of endogenous NE from the mesenteric vasculature of WKY and SHR in response to PNS.
J Pharmacol Exp Ther. 1987 Jun; 241(3):826-32.JP

Abstract

The release of endogenous norepinephrine (NE) from the mesenteric vasculature of the isolated mesentery of Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was determined in response to periarterial nerve stimulation (PNS). PNS caused a frequency-dependent release of NE that did not differ in WKY and SHR preparations at 4 to 10 Hz but was significantly greater from SHR preparations at 12 and 14 Hz. When expressed as NE release/stimulus, release was significantly greater from SHR preparations only at 14 Hz. Mesenteric vascular perfusion-pressure responses to PNS were significantly greater in SHR than in WKY preparations at 6 to 14 Hz. Mesenteric vascular perfusion-pressure responses to exogenous NE were significantly greater in SHR than in WKY preparations at all doses tested. Treatment of mesenteric vascular preparations from WKY and SHR with cocaine at two concentrations plus corticosterone to inhibit neuronal and extraneuronal NE uptake, respectively, increased PNS-induced overflow of NE significantly. There was no difference in the NE release/stimulus in response to PNS between WKY and SHR preparations after either concentration of cocaine. The enhanced PNS responses in SHR at higher frequencies appear to be due in part to decreased NE uptake.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3598905

Citation

Yamamoto, R, and W H. Cline. "Release of Endogenous NE From the Mesenteric Vasculature of WKY and SHR in Response to PNS." The Journal of Pharmacology and Experimental Therapeutics, vol. 241, no. 3, 1987, pp. 826-32.
Yamamoto R, Cline WH. Release of endogenous NE from the mesenteric vasculature of WKY and SHR in response to PNS. J Pharmacol Exp Ther. 1987;241(3):826-32.
Yamamoto, R., & Cline, W. H. (1987). Release of endogenous NE from the mesenteric vasculature of WKY and SHR in response to PNS. The Journal of Pharmacology and Experimental Therapeutics, 241(3), 826-32.
Yamamoto R, Cline WH. Release of Endogenous NE From the Mesenteric Vasculature of WKY and SHR in Response to PNS. J Pharmacol Exp Ther. 1987;241(3):826-32. PubMed PMID: 3598905.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release of endogenous NE from the mesenteric vasculature of WKY and SHR in response to PNS. AU - Yamamoto,R, AU - Cline,W H,Jr PY - 1987/6/1/pubmed PY - 2001/3/28/medline PY - 1987/6/1/entrez SP - 826 EP - 32 JF - The Journal of pharmacology and experimental therapeutics JO - J Pharmacol Exp Ther VL - 241 IS - 3 N2 - The release of endogenous norepinephrine (NE) from the mesenteric vasculature of the isolated mesentery of Wistar Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) was determined in response to periarterial nerve stimulation (PNS). PNS caused a frequency-dependent release of NE that did not differ in WKY and SHR preparations at 4 to 10 Hz but was significantly greater from SHR preparations at 12 and 14 Hz. When expressed as NE release/stimulus, release was significantly greater from SHR preparations only at 14 Hz. Mesenteric vascular perfusion-pressure responses to PNS were significantly greater in SHR than in WKY preparations at 6 to 14 Hz. Mesenteric vascular perfusion-pressure responses to exogenous NE were significantly greater in SHR than in WKY preparations at all doses tested. Treatment of mesenteric vascular preparations from WKY and SHR with cocaine at two concentrations plus corticosterone to inhibit neuronal and extraneuronal NE uptake, respectively, increased PNS-induced overflow of NE significantly. There was no difference in the NE release/stimulus in response to PNS between WKY and SHR preparations after either concentration of cocaine. The enhanced PNS responses in SHR at higher frequencies appear to be due in part to decreased NE uptake. SN - 0022-3565 UR - https://www.unboundmedicine.com/medline/citation/3598905/Release_of_endogenous_NE_from_the_mesenteric_vasculature_of_WKY_and_SHR_in_response_to_PNS_ L2 - https://jpet.aspetjournals.org/cgi/pmidlookup?view=long&pmid=3598905 DB - PRIME DP - Unbound Medicine ER -