Tags

Type your tag names separated by a space and hit enter

Alloimmune neonatal neutropenia--a neglected diagnosis?
Med J Aust. 1987 Aug 03; 147(3):139-41.MJ

Abstract

Alloimmune neonatal neutropenia is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Within the first few weeks of life, the infant may succumb to localized or generalized bacterial infections. Haematologically, the mother is normal, but the infant is severely neutropenic. The incidence of this condition is one in 2000 neonates, but it can be overlooked easily if specialized testing is not performed in neonates with unexplained neutropenia. It is generally a self-limiting disorder, but severe infection may result in a 5% mortality. The clinical and serological features of four cases are described. The treatment of severe infections in infants with alloimmune neonatal neutropenia is essential, but the use of prophylactic antibiotic therapy during the period of neutropenia is not warranted.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3600474

Citation

Minchinton, R M., and K M. McGrath. "Alloimmune Neonatal Neutropenia--a Neglected Diagnosis?" The Medical Journal of Australia, vol. 147, no. 3, 1987, pp. 139-41.
Minchinton RM, McGrath KM. Alloimmune neonatal neutropenia--a neglected diagnosis? Med J Aust. 1987;147(3):139-41.
Minchinton, R. M., & McGrath, K. M. (1987). Alloimmune neonatal neutropenia--a neglected diagnosis? The Medical Journal of Australia, 147(3), 139-41.
Minchinton RM, McGrath KM. Alloimmune Neonatal Neutropenia--a Neglected Diagnosis. Med J Aust. 1987 Aug 3;147(3):139-41. PubMed PMID: 3600474.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alloimmune neonatal neutropenia--a neglected diagnosis? AU - Minchinton,R M, AU - McGrath,K M, PY - 1987/8/3/pubmed PY - 1987/8/3/medline PY - 1987/8/3/entrez SP - 139 EP - 41 JF - The Medical journal of Australia JO - Med J Aust VL - 147 IS - 3 N2 - Alloimmune neonatal neutropenia is due to maternal IgG neutrophil-specific antibodies that cross the placenta to sensitize fetal neutrophils and cause neutropenia in the neonate. Within the first few weeks of life, the infant may succumb to localized or generalized bacterial infections. Haematologically, the mother is normal, but the infant is severely neutropenic. The incidence of this condition is one in 2000 neonates, but it can be overlooked easily if specialized testing is not performed in neonates with unexplained neutropenia. It is generally a self-limiting disorder, but severe infection may result in a 5% mortality. The clinical and serological features of four cases are described. The treatment of severe infections in infants with alloimmune neonatal neutropenia is essential, but the use of prophylactic antibiotic therapy during the period of neutropenia is not warranted. SN - 0025-729X UR - https://www.unboundmedicine.com/medline/citation/3600474/Alloimmune_neonatal_neutropenia__a_neglected_diagnosis L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3600474.ui DB - PRIME DP - Unbound Medicine ER -