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Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based on Y Chromosome STRs and SNPs.
Genes (Basel). 2022 07 29; 13(8)G

Abstract

Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) are genetic markers on the male Y chromosome for individual identification, forensic applications, and paternal genetic history analysis. In this study we successfully genotyped 38 Y-STR loci and 24 Y-SNP loci of Pudong Han (n = 689) and Chongming Han (n = 530) in Shanghai. The haplotype diversity of the Y filer platinum genotyping system was the highest in the Han population in the Pudong area of Shanghai (0.99996) and Chongming Island (0.99997). The proportion of unique haplotypes was 97.10% (Pudong) and 98.49% (Chongming), respectively. The multidimensional scaling analysis and phylogenetic analysis were performed according to the genetic distance Rst, which was calculated based on the Y-STR gene frequency data. Moreover, we made a comparison on the frequency distribution analysis and principal component analysis of haplogroups in both populations. As a result, Shanghai Pudong Han, Chongming Island Han, and Jiangsu Han were determined to have a strong genetic affinity. The haplogroup distribution characteristics of the Pudong Han and Chongming Han populations were similar to those of the southern Han population. The results of haplotype network analysis showed that Jiangsu Wujiang Han and Jiangsu Changshu Han had more paternal genetic contributions to the formation of Shanghai Pudong Han and Chongming Island Han. Through the joint analysis of SNPs and STRs, this study deeply analyzed the paternal genetic structure of the Pudong Han and Chongming Han populations. The addition of Y-SNP haplogroups to forensic applications can provide information for pedigree investigation.

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Authors+Show Affiliations

Zhang X
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.
Tang Z
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.
Wang B
Criminal Investigation Department of Shanghai, Pudong New Area, Shanghai 200120, China.
Zhou X
Criminal Investigation Department of Shanghai, Chongming Island, Shanghai 202150, China.
Zhou L
Criminal Investigation Department of Shanghai, Chongming Island, Shanghai 202150, China.
Zhang G
Criminal Investigation Department of Shanghai, Pudong New Area, Shanghai 200120, China.
Tian J
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.
Zhao Y
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.
Yao Z
Criminal Investigation Department of Shanghai, Pudong New Area, Shanghai 200120, China.
Tian L
Criminal Investigation Department of Shanghai, Pudong New Area, Shanghai 200120, China.
Zhang S
Academy of Forensic Science, Ministry of Justice, Shanghai 200063, China.
Xia H
School of Mathematical Sciences, Tongji University, Shanghai 200092, China.
Jin L
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.
Li C
Academy of Forensic Science, Ministry of Justice, Shanghai 200063, China.
Li S
Department of Anthropology and Human Genetics, School of Life Sciences, Fudan University, Shanghai 200438, China. Human Phenome Institute, Fudan University, Shanghai 200438, China.

MeSH

ChinaChromosomes, Human, YEthnicityGenetics, PopulationHumansMaleMicrosatellite RepeatsPhylogenyPolymorphism, Single Nucleotide

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36011274

Citation

Zhang, Xiao, et al. "Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based On Y Chromosome STRs and SNPs." Genes, vol. 13, no. 8, 2022.
Zhang X, Tang Z, Wang B, et al. Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based on Y Chromosome STRs and SNPs. Genes (Basel). 2022;13(8).
Zhang, X., Tang, Z., Wang, B., Zhou, X., Zhou, L., Zhang, G., Tian, J., Zhao, Y., Yao, Z., Tian, L., Zhang, S., Xia, H., Jin, L., Li, C., & Li, S. (2022). Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based on Y Chromosome STRs and SNPs. Genes, 13(8). https://doi.org/10.3390/genes13081363
Zhang X, et al. Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based On Y Chromosome STRs and SNPs. Genes (Basel). 2022 07 29;13(8) PubMed PMID: 36011274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Forensic Analysis and Genetic Structure Construction of Chinese Chongming Island Han Based on Y Chromosome STRs and SNPs. AU - Zhang,Xiao, AU - Tang,Zhen, AU - Wang,Bin, AU - Zhou,Xindao, AU - Zhou,Limin, AU - Zhang,Gongying, AU - Tian,Junzhe, AU - Zhao,Yiqi, AU - Yao,Zhiqing, AU - Tian,Lu, AU - Zhang,Suhua, AU - Xia,Hao, AU - Jin,Li, AU - Li,Chengtao, AU - Li,Shilin, Y1 - 2022/07/29/ PY - 2022/04/17/received PY - 2022/07/26/revised PY - 2022/07/27/accepted PY - 2022/8/26/entrez PY - 2022/8/27/pubmed PY - 2022/8/30/medline KW - Chongming island KW - Y-SNP KW - Y-STR KW - population differentiation JF - Genes JO - Genes (Basel) VL - 13 IS - 8 N2 - Y-chromosome short tandem repeat (Y-STR) and Y-chromosome single nucleotide polymorphism (Y-SNP) are genetic markers on the male Y chromosome for individual identification, forensic applications, and paternal genetic history analysis. In this study we successfully genotyped 38 Y-STR loci and 24 Y-SNP loci of Pudong Han (n = 689) and Chongming Han (n = 530) in Shanghai. The haplotype diversity of the Y filer platinum genotyping system was the highest in the Han population in the Pudong area of Shanghai (0.99996) and Chongming Island (0.99997). The proportion of unique haplotypes was 97.10% (Pudong) and 98.49% (Chongming), respectively. The multidimensional scaling analysis and phylogenetic analysis were performed according to the genetic distance Rst, which was calculated based on the Y-STR gene frequency data. Moreover, we made a comparison on the frequency distribution analysis and principal component analysis of haplogroups in both populations. As a result, Shanghai Pudong Han, Chongming Island Han, and Jiangsu Han were determined to have a strong genetic affinity. The haplogroup distribution characteristics of the Pudong Han and Chongming Han populations were similar to those of the southern Han population. The results of haplotype network analysis showed that Jiangsu Wujiang Han and Jiangsu Changshu Han had more paternal genetic contributions to the formation of Shanghai Pudong Han and Chongming Island Han. Through the joint analysis of SNPs and STRs, this study deeply analyzed the paternal genetic structure of the Pudong Han and Chongming Han populations. The addition of Y-SNP haplogroups to forensic applications can provide information for pedigree investigation. SN - 2073-4425 UR - https://www.unboundmedicine.com/medline/citation/36011274/Forensic_Analysis_and_Genetic_Structure_Construction_of_Chinese_Chongming_Island_Han_Based_on_Y_Chromosome_STRs_and_SNPs_ DB - PRIME DP - Unbound Medicine ER -