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The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials.
J Clin Med. 2022 Aug 10; 11(16)JC

Abstract

The aim of the report was to determine the effects of soy isoflavones on lumbar spine, femoral neck, and total hip bone mineral density (BMD) in menopausal women. MEDLINE (PubMed), EMBASE, and Cochrane Library databases were searched for articles published in English during 1995-2019. Studies were identified and reviewed for inclusion and exclusion eligibility. Weighted mean differences (WMD) were calculated for each study and were pooled by using the random effects model. Eighteen randomized controlled trials were selected for meta-analysis. Different types of soy phytoestrogens, i.e., genistein extracts, soy isoflavones extracts, soy protein isolate, and foods containing diverse amounts of isoflavones were used in the studies. The analysis showed that daily intake of 106 (range, 40-300) mg of isoflavones for 6-24 months moderately but statistically significantly positively affects BMD, compared with controls: lumbar spine WMD = 1.63 (95% CI: 0.51 to 2.75)%, p = 0004; femoral neck WMD = 1.87 (95% CI: 0.14 to 3.60)%, p = 0.034; and total hip WMD = 0.39 (95% CI: 0.08 to 0.69)%, p = 0.013. Subgroups analyses indicated that the varying effects of isoflavones on BMD across the trials might be associated with intervention duration, racial diversity (Caucasian, Asian), time after menopause, form of supplements (especially genistein), and dose of isoflavones. Our review and meta-analysis suggest that soy isoflavones are effective in slowing down bone loss after menopause.

Authors+Show Affiliations

Department of Medical Informatics and Statistics with e-Health Lab, Medical University of Lublin, 20-090 Lublin, Poland.Specialistic Medical Center Czechow, 20-848 Lublin, Poland.Department of Social Medicine and Public Health, Warsaw Medical University, 02-007 Warsaw, Poland.Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.I Chair and Department of Oncological Gynaecology and Gynaecology, Medical University of Lublin, 20-081 Lublin, Poland.Department of Environmental Hazards Prevention, Allergology and Immunology, Warsaw Medical University, 02-091 Warsaw, Poland.Department of Economics of Health and Medical Law, Medical University of Warsaw, 02-091 Warsaw, Poland.Medical Faculty, Lazarski University, 02-662 Warsaw, Poland.School of Public Health, Centre of Postgraduate Medical Education of Warsaw, 01-826 Warsaw, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36012916

Citation

Barańska, Agnieszka, et al. "The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: a Systematic Review With Meta-Analysis of Randomized Controlled Trials." Journal of Clinical Medicine, vol. 11, no. 16, 2022.
Barańska A, Kanadys W, Bogdan M, et al. The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2022;11(16).
Barańska, A., Kanadys, W., Bogdan, M., Stępień, E., Barczyński, B., Kłak, A., Augustynowicz, A., Szajnik, M., & Religioni, U. (2022). The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. Journal of Clinical Medicine, 11(16). https://doi.org/10.3390/jcm11164676
Barańska A, et al. The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: a Systematic Review With Meta-Analysis of Randomized Controlled Trials. J Clin Med. 2022 Aug 10;11(16) PubMed PMID: 36012916.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Role of Soy Isoflavones in the Prevention of Bone Loss in Postmenopausal Women: A Systematic Review with Meta-Analysis of Randomized Controlled Trials. AU - Barańska,Agnieszka, AU - Kanadys,Wiesław, AU - Bogdan,Magdalena, AU - Stępień,Ewa, AU - Barczyński,Bartłomiej, AU - Kłak,Anna, AU - Augustynowicz,Anna, AU - Szajnik,Marta, AU - Religioni,Urszula, Y1 - 2022/08/10/ PY - 2022/06/29/received PY - 2022/08/03/revised PY - 2022/08/09/accepted PY - 2022/8/26/entrez PY - 2022/8/27/pubmed PY - 2022/8/27/medline KW - bone loss KW - bone mass KW - meta-analysis KW - postmenopausal woman KW - randomized controlled trials KW - soy JF - Journal of clinical medicine JO - J Clin Med VL - 11 IS - 16 N2 - The aim of the report was to determine the effects of soy isoflavones on lumbar spine, femoral neck, and total hip bone mineral density (BMD) in menopausal women. MEDLINE (PubMed), EMBASE, and Cochrane Library databases were searched for articles published in English during 1995-2019. Studies were identified and reviewed for inclusion and exclusion eligibility. Weighted mean differences (WMD) were calculated for each study and were pooled by using the random effects model. Eighteen randomized controlled trials were selected for meta-analysis. Different types of soy phytoestrogens, i.e., genistein extracts, soy isoflavones extracts, soy protein isolate, and foods containing diverse amounts of isoflavones were used in the studies. The analysis showed that daily intake of 106 (range, 40-300) mg of isoflavones for 6-24 months moderately but statistically significantly positively affects BMD, compared with controls: lumbar spine WMD = 1.63 (95% CI: 0.51 to 2.75)%, p = 0004; femoral neck WMD = 1.87 (95% CI: 0.14 to 3.60)%, p = 0.034; and total hip WMD = 0.39 (95% CI: 0.08 to 0.69)%, p = 0.013. Subgroups analyses indicated that the varying effects of isoflavones on BMD across the trials might be associated with intervention duration, racial diversity (Caucasian, Asian), time after menopause, form of supplements (especially genistein), and dose of isoflavones. Our review and meta-analysis suggest that soy isoflavones are effective in slowing down bone loss after menopause. SN - 2077-0383 UR - https://www.unboundmedicine.com/medline/citation/36012916/The_Role_of_Soy_Isoflavones_in_the_Prevention_of_Bone_Loss_in_Postmenopausal_Women:_A_Systematic_Review_with_Meta_Analysis_of_Randomized_Controlled_Trials_ DB - PRIME DP - Unbound Medicine ER -
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