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Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias.
Medicina (Kaunas). 2022 Jul 30; 58(8)M

Abstract

Background and Objectives: Alzheimer's disease (AD) is the most common form of dementia, with the risk of developing it attributed to non-modifiable and modifiable factors. Currently, there is no cure for AD. A plant-based diet may protect against cognitive decline, due to the effects of plant-based nutrients such as vitamins, antioxidants, and fiber. The aim of the review is to summarize current literature on plant-based nutrients and their impact on cognition. Materials and Methods: A search was conducted on PubMed for clinical and murine studies, using combinations of the following words: "Alzheimer's disease", "dementia", "cognition", "plant-based diet", "mild cognitive impairment", "vitamin B", "vitamin C", "vitamin E, "beta carotene", "antioxidants", "fiber", "vitamin K", "Mediterranean diet", "vitamin D", and "mushrooms". Results and Conclusions: A diet rich in vitamin B and antioxidants can benefit the cognitive functions of individuals as shown in randomized clinical trials. Vitamin K is associated with improved cognition, although large randomized controlled trials need to be done. Fiber has been shown to prevent cognitive decline in animal studies. Vitamin D may contribute to cognitive health via anti-inflammatory processes. Several medical organizations have recommended a plant-based diet for optimizing cognitive health and potentially helping to prevent dementia.

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Authors+Show Affiliations

Ding H
NYU Long Island School of Medicine, Mineola, NY 11501, USA.
Reiss AB
NYU Long Island School of Medicine, Mineola, NY 11501, USA.
Pinkhasov A
NYU Long Island School of Medicine, Mineola, NY 11501, USA.
Kasselman LJ
NYU Long Island School of Medicine, Mineola, NY 11501, USA.

MeSH

Alzheimer DiseaseAnimalsAntioxidantsCognitionCognitive DysfunctionMiceVitamin EVitamins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

36013492

Citation

Ding, Helen, et al. "Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias." Medicina (Kaunas, Lithuania), vol. 58, no. 8, 2022.
Ding H, Reiss AB, Pinkhasov A, et al. Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. Medicina (Kaunas). 2022;58(8).
Ding, H., Reiss, A. B., Pinkhasov, A., & Kasselman, L. J. (2022). Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. Medicina (Kaunas, Lithuania), 58(8). https://doi.org/10.3390/medicina58081025
Ding H, et al. Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. Medicina (Kaunas). 2022 Jul 30;58(8) PubMed PMID: 36013492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias. AU - Ding,Helen, AU - Reiss,Allison B, AU - Pinkhasov,Aaron, AU - Kasselman,Lora J, Y1 - 2022/07/30/ PY - 2022/06/24/received PY - 2022/07/18/revised PY - 2022/07/25/accepted PY - 2022/8/26/entrez PY - 2022/8/27/pubmed PY - 2022/8/30/medline KW - Alzheimer’s disease KW - B vitamins KW - antioxidants KW - cognition KW - fiber KW - plant-based diet KW - vitamin K JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 58 IS - 8 N2 - Background and Objectives: Alzheimer's disease (AD) is the most common form of dementia, with the risk of developing it attributed to non-modifiable and modifiable factors. Currently, there is no cure for AD. A plant-based diet may protect against cognitive decline, due to the effects of plant-based nutrients such as vitamins, antioxidants, and fiber. The aim of the review is to summarize current literature on plant-based nutrients and their impact on cognition. Materials and Methods: A search was conducted on PubMed for clinical and murine studies, using combinations of the following words: "Alzheimer's disease", "dementia", "cognition", "plant-based diet", "mild cognitive impairment", "vitamin B", "vitamin C", "vitamin E, "beta carotene", "antioxidants", "fiber", "vitamin K", "Mediterranean diet", "vitamin D", and "mushrooms". Results and Conclusions: A diet rich in vitamin B and antioxidants can benefit the cognitive functions of individuals as shown in randomized clinical trials. Vitamin K is associated with improved cognition, although large randomized controlled trials need to be done. Fiber has been shown to prevent cognitive decline in animal studies. Vitamin D may contribute to cognitive health via anti-inflammatory processes. Several medical organizations have recommended a plant-based diet for optimizing cognitive health and potentially helping to prevent dementia. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/36013492/Plants_Plants_and_More_Plants:_Plant_Derived_Nutrients_and_Their_Protective_Roles_in_Cognitive_Function_Alzheimer's_Disease_and_Other_Dementias_ DB - PRIME DP - Unbound Medicine ER -