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Role of microRNA alternation in the pathogenesis of gouty arthritis.
Front Endocrinol (Lausanne). 2022; 13:967769.FE

Abstract

Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3' untranslated region (UTR) of mRNA and regulate the expression of a variety of proteins at the post-transcriptional level. In recent years, attention has been focused on the role of miRNAs in various inflammatory diseases, including gouty arthritis. It is thought that miRNAs may regulate immune function and inflammatory responses, thereby influencing the onset and progression of the disease. This article mainly reviewed the roles of miRNAs in the pathogenesis of gouty arthritis and prospected their potential as diagnostic and prognostic relevant biomarkers and as possible therapeutic targets.

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Authors+Show Affiliations

Luo Z
The First Affifiliated Hospital, Anhui Medical University, Hefei, China. Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Yang F
The First Affifiliated Hospital, Anhui Medical University, Hefei, China.
Hong S
The First Affifiliated Hospital, Anhui Medical University, Hefei, China.
Wang J
The First Affifiliated Hospital, Anhui Medical University, Hefei, China.
Chen B
The First Affifiliated Hospital, Anhui Medical University, Hefei, China.
Li L
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Yang J
Institute of clinical pharmacology, Anhui Medical University, Hefei, China.
Yao Y
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Yang C
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Hu Y
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Wang S
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Xu T
Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. Anhui Institute of Innovative Drugs, Hefei, China. School of Pharmacy, Anhui Medical University, Hefei, China.
Wu J
Geriatric Department, The First Affifiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

MeSH

Arthritis, GoutyGoutHumansMicroRNAsUric Acid

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36034424

Citation

Luo, Zhipan, et al. "Role of microRNA Alternation in the Pathogenesis of Gouty Arthritis." Frontiers in Endocrinology, vol. 13, 2022, p. 967769.
Luo Z, Yang F, Hong S, et al. Role of microRNA alternation in the pathogenesis of gouty arthritis. Front Endocrinol (Lausanne). 2022;13:967769.
Luo, Z., Yang, F., Hong, S., Wang, J., Chen, B., Li, L., Yang, J., Yao, Y., Yang, C., Hu, Y., Wang, S., Xu, T., & Wu, J. (2022). Role of microRNA alternation in the pathogenesis of gouty arthritis. Frontiers in Endocrinology, 13, 967769. https://doi.org/10.3389/fendo.2022.967769
Luo Z, et al. Role of microRNA Alternation in the Pathogenesis of Gouty Arthritis. Front Endocrinol (Lausanne). 2022;13:967769. PubMed PMID: 36034424.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of microRNA alternation in the pathogenesis of gouty arthritis. AU - Luo,Zhipan, AU - Yang,Fan, AU - Hong,Shaocheng, AU - Wang,Jianpeng, AU - Chen,Bangjie, AU - Li,Liangyun, AU - Yang,Junfa, AU - Yao,Yan, AU - Yang,Chenchen, AU - Hu,Ying, AU - Wang,Shuxian, AU - Xu,Tao, AU - Wu,Jun, Y1 - 2022/08/11/ PY - 2022/06/13/received PY - 2022/07/19/accepted PY - 2022/8/29/entrez PY - 2022/8/30/pubmed PY - 2022/8/31/medline KW - MicroRNA KW - biomarker KW - cellular signaling pathway KW - gouty arthritis KW - hyperuricemia SP - 967769 EP - 967769 JF - Frontiers in endocrinology JO - Front Endocrinol (Lausanne) VL - 13 N2 - Gouty arthritis is a common inflammatory disease. The condition is triggered by a disorder of uric acid metabolism, which causes urate deposition and gout flares. MicroRNAs are a class of conserved small non-coding RNAs that bind to the 3' untranslated region (UTR) of mRNA and regulate the expression of a variety of proteins at the post-transcriptional level. In recent years, attention has been focused on the role of miRNAs in various inflammatory diseases, including gouty arthritis. It is thought that miRNAs may regulate immune function and inflammatory responses, thereby influencing the onset and progression of the disease. This article mainly reviewed the roles of miRNAs in the pathogenesis of gouty arthritis and prospected their potential as diagnostic and prognostic relevant biomarkers and as possible therapeutic targets. SN - 1664-2392 UR - https://www.unboundmedicine.com/medline/citation/36034424/Role_of_microRNA_alternation_in_the_pathogenesis_of_gouty_arthritis_ DB - PRIME DP - Unbound Medicine ER -