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Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin.
Int J Biol Macromol. 2022 Nov 30; 221:48-60.IJ

Abstract

Escin is an amphiphilic and weakly acidic drug that oral administration may lead to the irritation of gastric mucosa. The entrapment of escin into chitosan (CH)/xanthan gum (XG)-based polyelectrolyte complexes (PECs) can facilitate controlled drug release which may be beneficial for the reduction of its side effects. This study aimed to investigate the influence of escin content and drying method on the formation, physicochemical, and controlled, pH-dependent drug release properties of CH/XG-based PECs. Measurements of transmittance, conductivity, and rheological characterization confirmed the formation of CH/XG-based PECs with escin entrapped at escin-to-polymers mass ratios 1:1, 1:2, and 1:4. Ambient-dried PECs had higher yield, entrapment efficiency, and escin content in comparison with spray-dried ones. FT-IR spectra confirmed the interactions between CH, XG, and escin, which were stronger in ambient-dried PECs. PXRD and DSC analyses showed the amorphous escin character in all dry PECs, regardless of the drying method. The most promising controlled and pH-dependent in vitro escin release was from the ambient-dried PEC at the escin-to-polymers mass ratio of 1:1. For that reason and due to the highest yield and entrapment efficiency, this carrier has the potential to prevent the irritation of gastric mucosa after oral administration of escin.

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Authors+Show Affiliations

Ćirić A
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ana.ciric@pharmacy.bg.ac.rs.
Budinčić JM
University of Novi Sad, Faculty of Technology, Department of Biotechnology and Pharmaceutical Engineering, Boulevard cara Lazara 1, 21102 Novi Sad, Serbia. Electronic address: jelenamilinkovic@tf.uns.ac.rs.
Medarević Đ
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: djordje.medarevic@pharmacy.bg.ac.rs.
Dobričić V
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: vladimir.dobricic@pharmacy.bg.ac.rs.
Rmandić M
University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: milena.rmandic@pharmacy.bg.ac.rs.
Barudžija T
University of Belgrade, Vinča Institute of Nuclear Sciences, Laboratory for Theoretical Physics and Condensed Matter Physics, Mike Petrovića Alasa 12-14, 11351 Belgrade, Serbia. Electronic address: tbarudzija@vin.bg.ac.rs.
Malenović A
University of Belgrade, Faculty of Pharmacy, Department of Drug Analysis, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: andjelija.malenovic@pharmacy.bg.ac.rs.
Petrović L
University of Novi Sad, Faculty of Technology, Department of Biotechnology and Pharmaceutical Engineering, Boulevard cara Lazara 1, 21102 Novi Sad, Serbia. Electronic address: lidijap@uns.ac.rs.
Djekic L
University of Belgrade, Faculty of Pharmacy, Department of Pharmaceutical Technology and Cosmetology, Vojvode Stepe 450, 11221 Belgrade, Serbia. Electronic address: ljiljanadjek@gmail.com.

MeSH

PolyelectrolytesChitosanEscinDrug Delivery SystemsSpectroscopy, Fourier Transform InfraredHydrogen-Ion Concentration

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36058395

Citation

Ćirić, Ana, et al. "Evaluation of Chitosan/xanthan Gum Polyelectrolyte Complexes Potential for pH-dependent Oral Delivery of Escin." International Journal of Biological Macromolecules, vol. 221, 2022, pp. 48-60.
Ćirić A, Budinčić JM, Medarević Đ, et al. Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin. Int J Biol Macromol. 2022;221:48-60.
Ćirić, A., Budinčić, J. M., Medarević, Đ., Dobričić, V., Rmandić, M., Barudžija, T., Malenović, A., Petrović, L., & Djekic, L. (2022). Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin. International Journal of Biological Macromolecules, 221, 48-60. https://doi.org/10.1016/j.ijbiomac.2022.08.190
Ćirić A, et al. Evaluation of Chitosan/xanthan Gum Polyelectrolyte Complexes Potential for pH-dependent Oral Delivery of Escin. Int J Biol Macromol. 2022 Nov 30;221:48-60. PubMed PMID: 36058395.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of chitosan/xanthan gum polyelectrolyte complexes potential for pH-dependent oral delivery of escin. AU - Ćirić,Ana, AU - Budinčić,Jelena Milinković, AU - Medarević,Đorđe, AU - Dobričić,Vladimir, AU - Rmandić,Milena, AU - Barudžija,Tanja, AU - Malenović,Anđelija, AU - Petrović,Lidija, AU - Djekic,Ljiljana, Y1 - 2022/09/02/ PY - 2022/07/15/received PY - 2022/08/17/revised PY - 2022/08/30/accepted PY - 2022/9/5/pubmed PY - 2022/11/3/medline PY - 2022/9/4/entrez KW - Chitosan KW - Escin KW - Polyelectrolyte complex KW - Xanthan gum KW - pH-dependent drug release SP - 48 EP - 60 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 221 N2 - Escin is an amphiphilic and weakly acidic drug that oral administration may lead to the irritation of gastric mucosa. The entrapment of escin into chitosan (CH)/xanthan gum (XG)-based polyelectrolyte complexes (PECs) can facilitate controlled drug release which may be beneficial for the reduction of its side effects. This study aimed to investigate the influence of escin content and drying method on the formation, physicochemical, and controlled, pH-dependent drug release properties of CH/XG-based PECs. Measurements of transmittance, conductivity, and rheological characterization confirmed the formation of CH/XG-based PECs with escin entrapped at escin-to-polymers mass ratios 1:1, 1:2, and 1:4. Ambient-dried PECs had higher yield, entrapment efficiency, and escin content in comparison with spray-dried ones. FT-IR spectra confirmed the interactions between CH, XG, and escin, which were stronger in ambient-dried PECs. PXRD and DSC analyses showed the amorphous escin character in all dry PECs, regardless of the drying method. The most promising controlled and pH-dependent in vitro escin release was from the ambient-dried PEC at the escin-to-polymers mass ratio of 1:1. For that reason and due to the highest yield and entrapment efficiency, this carrier has the potential to prevent the irritation of gastric mucosa after oral administration of escin. SN - 1879-0003 UR - https://www.unboundmedicine.com/medline/citation/36058395/Evaluation_of_chitosan/xanthan_gum_polyelectrolyte_complexes_potential_for_pH_dependent_oral_delivery_of_escin_ DB - PRIME DP - Unbound Medicine ER -