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The painful crisis of homozygous sickle cell disease. A study of the risk factors.
Arch Intern Med. 1987 Jul; 147(7):1231-4.AI

Abstract

Some epidemiologic features of the painful crisis in homozygous sickle cell disease were examined in a retrospective study of 995 painful crises. Previously reported associations with cold weather and pregnancy were confirmed. There was a striking increase in painful crises in male patients between the ages of 15 and 25 years, whereas female patients showed little age-related change. The frequency of painful crises correlated positively with hemoglobin levels and reticulocyte counts in both sexes and negatively with mean corpuscular volume in female patients. There was a striking increase in painful crises in male patients with hemoglobin levels above 8.5 g/dL (greater than 85 g/L). High hemoglobin levels appear to be an important risk factor for painful crises.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3606281

Citation

Baum, K F., et al. "The Painful Crisis of Homozygous Sickle Cell Disease. a Study of the Risk Factors." Archives of Internal Medicine, vol. 147, no. 7, 1987, pp. 1231-4.
Baum KF, Dunn DT, Maude GH, et al. The painful crisis of homozygous sickle cell disease. A study of the risk factors. Arch Intern Med. 1987;147(7):1231-4.
Baum, K. F., Dunn, D. T., Maude, G. H., & Serjeant, G. R. (1987). The painful crisis of homozygous sickle cell disease. A study of the risk factors. Archives of Internal Medicine, 147(7), 1231-4.
Baum KF, et al. The Painful Crisis of Homozygous Sickle Cell Disease. a Study of the Risk Factors. Arch Intern Med. 1987;147(7):1231-4. PubMed PMID: 3606281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The painful crisis of homozygous sickle cell disease. A study of the risk factors. AU - Baum,K F, AU - Dunn,D T, AU - Maude,G H, AU - Serjeant,G R, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 1231 EP - 4 JF - Archives of internal medicine JO - Arch Intern Med VL - 147 IS - 7 N2 - Some epidemiologic features of the painful crisis in homozygous sickle cell disease were examined in a retrospective study of 995 painful crises. Previously reported associations with cold weather and pregnancy were confirmed. There was a striking increase in painful crises in male patients between the ages of 15 and 25 years, whereas female patients showed little age-related change. The frequency of painful crises correlated positively with hemoglobin levels and reticulocyte counts in both sexes and negatively with mean corpuscular volume in female patients. There was a striking increase in painful crises in male patients with hemoglobin levels above 8.5 g/dL (greater than 85 g/L). High hemoglobin levels appear to be an important risk factor for painful crises. SN - 0003-9926 UR - https://www.unboundmedicine.com/medline/citation/3606281/The_painful_crisis_of_homozygous_sickle_cell_disease__A_study_of_the_risk_factors_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/vol/147/pg/1231 DB - PRIME DP - Unbound Medicine ER -