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Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures.
Brain Res. 1987 May 26; 412(1):161-4.BR

Abstract

In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the result of the myoclonus, not the somatostatin depletion as previously suggested. Prior administration of the short-acting benzodiazepine midazolam (5 mg/kg, i.p.) eliminated the CSH-induced myoclonus and prevented the long-term inhibition of kindled seizures. These results suggest that the CSH-induced long-term inhibition of kindled seizures is the result of an interaction between the myoclonic seizure and a subsequent kindled seizure.

Authors

Cottrell GA
No affiliation info available
Robertson HA
No affiliation info available

MeSH

AnimalsCysteamineKindling, NeurologicMaleMidazolamMyoclonusNeural InhibitionRatsRats, Inbred StrainsSeizures

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3607450

Citation

Cottrell, G A., and H A. Robertson. "Prevention of Cysteamine-induced Myoclonus Blocks the Long-term Inhibition of Kindled Seizures." Brain Research, vol. 412, no. 1, 1987, pp. 161-4.
Cottrell GA, Robertson HA. Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. Brain Res. 1987;412(1):161-4.
Cottrell, G. A., & Robertson, H. A. (1987). Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. Brain Research, 412(1), 161-4.
Cottrell GA, Robertson HA. Prevention of Cysteamine-induced Myoclonus Blocks the Long-term Inhibition of Kindled Seizures. Brain Res. 1987 May 26;412(1):161-4. PubMed PMID: 3607450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures. AU - Cottrell,G A, AU - Robertson,H A, PY - 1987/5/26/pubmed PY - 1987/5/26/medline PY - 1987/5/26/entrez SP - 161 EP - 4 JF - Brain research JO - Brain Res VL - 412 IS - 1 N2 - In kindled rats, the administration of cysteamine (CSH, 200 mg/kg, i.p.) 4 h prior to a kindled seizure leads to long-term (up to 10 days) inhibition of kindled seizures. CSH (200 mg/kg, i.p.) also induces myoclonic seizures in kindled rats. We suggest that the long-term inhibition of kindled seizures might be the result of the myoclonus, not the somatostatin depletion as previously suggested. Prior administration of the short-acting benzodiazepine midazolam (5 mg/kg, i.p.) eliminated the CSH-induced myoclonus and prevented the long-term inhibition of kindled seizures. These results suggest that the CSH-induced long-term inhibition of kindled seizures is the result of an interaction between the myoclonic seizure and a subsequent kindled seizure. SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/3607450/Prevention_of_cysteamine_induced_myoclonus_blocks_the_long_term_inhibition_of_kindled_seizures_ DB - PRIME DP - Unbound Medicine ER -