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[Effect of electroacupuncture combined with intradermal needling on simple obesity and serum intestinal lymphatic function-related factors].
Zhongguo Zhen Jiu. 2022 Sep 12; 42(9):966-70.ZZ

Abstract

OBJECTIVE

To assess the efficacy of the combined treatment with electroacupuncture (EA) and intradermal needling on simple obesity and explore its underlying effect mechanism.

METHODS

A total number of 116 patients with simple obesity were randomized into an observation group (58 cases, 3 cases dropped off and 2 cases removed) and a control group (58 cases, 4 cases dropped off and 1 cases removed). Patients in the control group received EA at Zhongwan (CV 12), Quchi (LI 11), Zusanli (ST 36), Pishu (BL 20), Weishu (BL 21), etc., for 30 min each time. On the base of the intervention as the control group, the patients in the observation group received the intradermal needling at Tianshu (ST 25), Daheng (SP 15), Zusanli (ST 36), Shangjuxu (ST 37), Quchi (LI 11), Pishu (BL 20) and Weishu (BL 21). In each group, the intervention was given once every two days, 3 times a week, consecutively for 3 months. Before and after treatment, the obesity indexes (body mass [BW], body mass index [BMI], body fat percentage [F%], adiposity [A] and waist circumference [WC]), the serum intestinal lymphatic function-related factors (vascular endothelial growth factor C [VEGF-C], delta-like ligand 4 [DLL4], adrenomedullin [ADM]), blood lipid (total cholesterol [TC], triglyceride [TG] and low density lipoprotein-cholesterol [LDL-C]), and fasting plasma glucose (FPG), fasting insulin (FINS) and insulin resistance index (HOMA-IR) were observed in the patients of both groups; and the efficacy was assessed.

RESULTS

The effective rate was 88.7% (47/53) in the observation group, higher than 71.7% (38/53) in the control group (P<0.05). After treatment, except FPG in the control group, BW, BMI, F%, A, WC, and the concentrations of serum VEGF-C, DLL4 and ADM, as well as TC, TG, LDL-C, FBG, FINS and HOMA-IR were all reduced compared with those before treatment in both groups (P<0.05). The reduction ranges of BW, BMI, F%, A, WC, and the concentrations of serum VEGF-C, DLL4 and ADM, and TC, LDL-C, FINS and HOMA-IR in the observation group were all larger than those in the control group (P<0.05).

CONCLUSION

Electroacupuncture combined with intradermal needling can reduce body weight and lipid, and improve insulin resistance in treatment of simple obesity, which is achieved probably through inhibiting lymphangiogenesis and promoting lymphatic endothelial permeability.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Xia MH
Key Laboratory of Combined Acupuncture and Medicine, Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China; Department of Acupuncture and Moxibustion, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province.
Yu Z
Key Laboratory of Combined Acupuncture and Medicine, Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.
Liu DH
Department of Acupuncture and Moxibustion, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province.
Ji HY
Clinical Laboratory, Affiliated Hospital of Nantong University, Nantong 226001, Jiangsu Province.
Xu B
Key Laboratory of Combined Acupuncture and Medicine, Ministry of Education, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China.

MeSH

Acupuncture PointsBlood GlucoseCholesterol, LDLElectroacupunctureHumansInsulin ResistanceIntestinesLipidsLymphocytesObesityObesity, MorbidTriglyceridesVascular Endothelial Growth Factor C

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

36075590

Citation

Xia, Ming-Hui, et al. "[Effect of Electroacupuncture Combined With Intradermal Needling On Simple Obesity and Serum Intestinal Lymphatic Function-related Factors]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 42, no. 9, 2022, pp. 966-70.
Xia MH, Yu Z, Liu DH, et al. [Effect of electroacupuncture combined with intradermal needling on simple obesity and serum intestinal lymphatic function-related factors]. Zhongguo Zhen Jiu. 2022;42(9):966-70.
Xia, M. H., Yu, Z., Liu, D. H., Ji, H. Y., & Xu, B. (2022). [Effect of electroacupuncture combined with intradermal needling on simple obesity and serum intestinal lymphatic function-related factors]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 42(9), 966-70. https://doi.org/10.13703/j.0255-2930.20220220-k0003
Xia MH, et al. [Effect of Electroacupuncture Combined With Intradermal Needling On Simple Obesity and Serum Intestinal Lymphatic Function-related Factors]. Zhongguo Zhen Jiu. 2022 Sep 12;42(9):966-70. PubMed PMID: 36075590.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of electroacupuncture combined with intradermal needling on simple obesity and serum intestinal lymphatic function-related factors]. AU - Xia,Ming-Hui, AU - Yu,Zhi, AU - Liu,Dong-Hua, AU - Ji,Huo-Yan, AU - Xu,Bin, PY - 2022/9/8/entrez PY - 2022/9/9/pubmed PY - 2022/9/14/medline KW - blood lipid KW - electroacupuncture KW - insulin resistance KW - intradermal needling KW - serum intestinal lymphatic function-related factors KW - simple obesity SP - 966 EP - 70 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 42 IS - 9 N2 - OBJECTIVE: To assess the efficacy of the combined treatment with electroacupuncture (EA) and intradermal needling on simple obesity and explore its underlying effect mechanism. METHODS: A total number of 116 patients with simple obesity were randomized into an observation group (58 cases, 3 cases dropped off and 2 cases removed) and a control group (58 cases, 4 cases dropped off and 1 cases removed). Patients in the control group received EA at Zhongwan (CV 12), Quchi (LI 11), Zusanli (ST 36), Pishu (BL 20), Weishu (BL 21), etc., for 30 min each time. On the base of the intervention as the control group, the patients in the observation group received the intradermal needling at Tianshu (ST 25), Daheng (SP 15), Zusanli (ST 36), Shangjuxu (ST 37), Quchi (LI 11), Pishu (BL 20) and Weishu (BL 21). In each group, the intervention was given once every two days, 3 times a week, consecutively for 3 months. Before and after treatment, the obesity indexes (body mass [BW], body mass index [BMI], body fat percentage [F%], adiposity [A] and waist circumference [WC]), the serum intestinal lymphatic function-related factors (vascular endothelial growth factor C [VEGF-C], delta-like ligand 4 [DLL4], adrenomedullin [ADM]), blood lipid (total cholesterol [TC], triglyceride [TG] and low density lipoprotein-cholesterol [LDL-C]), and fasting plasma glucose (FPG), fasting insulin (FINS) and insulin resistance index (HOMA-IR) were observed in the patients of both groups; and the efficacy was assessed. RESULTS: The effective rate was 88.7% (47/53) in the observation group, higher than 71.7% (38/53) in the control group (P<0.05). After treatment, except FPG in the control group, BW, BMI, F%, A, WC, and the concentrations of serum VEGF-C, DLL4 and ADM, as well as TC, TG, LDL-C, FBG, FINS and HOMA-IR were all reduced compared with those before treatment in both groups (P<0.05). The reduction ranges of BW, BMI, F%, A, WC, and the concentrations of serum VEGF-C, DLL4 and ADM, and TC, LDL-C, FINS and HOMA-IR in the observation group were all larger than those in the control group (P<0.05). CONCLUSION: Electroacupuncture combined with intradermal needling can reduce body weight and lipid, and improve insulin resistance in treatment of simple obesity, which is achieved probably through inhibiting lymphangiogenesis and promoting lymphatic endothelial permeability. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/36075590/[Effect_of_electroacupuncture_combined_with_intradermal_needling_on_simple_obesity_and_serum_intestinal_lymphatic_function_related_factors]_ DB - PRIME DP - Unbound Medicine ER -