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Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk.
J Clin Gastroenterol. 1987 Jun; 9(3):298-302.JC

Abstract

Atrophic gastritis with intestinal metaplasia is generally considered a precancerous lesion. We followed 261 patients with chronic atrophic gastritis and intestinal metaplasia, with and without gastric ulcer, every 12 months for 9 +/- 2 years by means of endoscopic and histological examination. In the presence of dysplasia, however, studies were carried out every 6 months in moderate cases, or every 3 months in severe cases. Patients with gastric ulcer received medical therapy for 8 weeks; if healing did not occur, treatment was continued. Only subjects with healed ulcers were admitted to the follow-up. To date, 205 subjects have been included in the study. Over a 10-year period, 16 patients with recurrent gastric ulcer and 12 patients with cancer in situ or in an early stage, were subjected to surgery. One case of advanced cancer was observed. Cancer has been found in five of 95 cases of atrophic gastritis with gastric ulcer (5.2%), and in 7 of 166 cases of atrophic gastritis without gastric ulcer (4.2%). The difference was not statistically significant. Our results confirm that gastric ulcer per se is not a high-risk condition, but it must be considered as an epiphenomenon on a background of epithelial atrophy.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3611683

Citation

Testoni, P A., et al. "Gastric Cancer in Chronic Atrophic Gastritis. Associated Gastric Ulcer Adds No Further Risk." Journal of Clinical Gastroenterology, vol. 9, no. 3, 1987, pp. 298-302.
Testoni PA, Masci E, Marchi R, et al. Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk. J Clin Gastroenterol. 1987;9(3):298-302.
Testoni, P. A., Masci, E., Marchi, R., Guslandi, M., Ronchi, G., & Tittobello, A. (1987). Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk. Journal of Clinical Gastroenterology, 9(3), 298-302.
Testoni PA, et al. Gastric Cancer in Chronic Atrophic Gastritis. Associated Gastric Ulcer Adds No Further Risk. J Clin Gastroenterol. 1987;9(3):298-302. PubMed PMID: 3611683.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gastric cancer in chronic atrophic gastritis. Associated gastric ulcer adds no further risk. AU - Testoni,P A, AU - Masci,E, AU - Marchi,R, AU - Guslandi,M, AU - Ronchi,G, AU - Tittobello,A, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 298 EP - 302 JF - Journal of clinical gastroenterology JO - J Clin Gastroenterol VL - 9 IS - 3 N2 - Atrophic gastritis with intestinal metaplasia is generally considered a precancerous lesion. We followed 261 patients with chronic atrophic gastritis and intestinal metaplasia, with and without gastric ulcer, every 12 months for 9 +/- 2 years by means of endoscopic and histological examination. In the presence of dysplasia, however, studies were carried out every 6 months in moderate cases, or every 3 months in severe cases. Patients with gastric ulcer received medical therapy for 8 weeks; if healing did not occur, treatment was continued. Only subjects with healed ulcers were admitted to the follow-up. To date, 205 subjects have been included in the study. Over a 10-year period, 16 patients with recurrent gastric ulcer and 12 patients with cancer in situ or in an early stage, were subjected to surgery. One case of advanced cancer was observed. Cancer has been found in five of 95 cases of atrophic gastritis with gastric ulcer (5.2%), and in 7 of 166 cases of atrophic gastritis without gastric ulcer (4.2%). The difference was not statistically significant. Our results confirm that gastric ulcer per se is not a high-risk condition, but it must be considered as an epiphenomenon on a background of epithelial atrophy. SN - 0192-0790 UR - https://www.unboundmedicine.com/medline/citation/3611683/Gastric_cancer_in_chronic_atrophic_gastritis__Associated_gastric_ulcer_adds_no_further_risk_ L2 - https://medlineplus.gov/stomachcancer.html DB - PRIME DP - Unbound Medicine ER -