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Does the Mediterranean diet reduce the odds of diabetic nephropathy in women? A case-control study.
Front Nutr. 2022; 9:984622.FN

Abstract

Background

In recent decades, the prevalence of chronic diseases such as diabetes is increasing. One of the major complications of diabetes is diabetic nephropathy (DN), so it is important to find a way that can delay or control the onset of DN. Therefore, in this study, we investigated the relationship between the Mediterranean diet (MED) and the odds of DN.

Methods

This case-control study was performed among 210 women (30-65 years) who were referred to the Kowsar Diabetes Clinic in Semnan, Iran. Biochemical variables and anthropometric measurements were assessed. The food frequency questionnaire (FFQ) was used to calculate dietary intakes. Data from dietary intakes based on the FFQ were used to evaluate the MED score. Logistic regression was used to examine the associations.

Results

Our results showed that in the crude model with higher adherence to the MED (OR: 0.272; 95% CI: 0.154, 0.481; P = 0.001), the odds of DN has reduced by 73%, and in model 1, after controlling for potential confounders, with higher adherence to the MED (OR: 0.239; 95% CI: 0.128, 0.447; P = 0.001), the odds of DN has reduced by 76% compared to low adherence. Also, in model 1, significant associations were observed between high consumption of grains (OR: 0.360; 95% CI: 0.191, 0.676; P = 0.001), legumes (OR: 0.156; 95% CI: 0.083, 0.292; P = 0.001), vegetables (OR: 0.273; 95% CI: 0.149, 0.501; P = 0.001), fruits (OR: 0.179; 95% CI: 0.093, 0.347; P = 0.001), fish (OR: 0.459; 95% CI: 0.254, 0.827; P = 0.01), and reduced odds of DN (P < 0.05).

Conclusion

We observed that with higher adherence to the MED, the odds of DN had reduced through mechanisms. However, additional studies are needed to confirm these findings.

Authors+Show Affiliations

Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36118745

Citation

Noori, Sahar, et al. "Does the Mediterranean Diet Reduce the Odds of Diabetic Nephropathy in Women? a Case-control Study." Frontiers in Nutrition, vol. 9, 2022, p. 984622.
Noori S, Mirzababaei A, Abaj F, et al. Does the Mediterranean diet reduce the odds of diabetic nephropathy in women? A case-control study. Front Nutr. 2022;9:984622.
Noori, S., Mirzababaei, A., Abaj, F., Ghaffarian-Ensaf, R., & Mirzaei, K. (2022). Does the Mediterranean diet reduce the odds of diabetic nephropathy in women? A case-control study. Frontiers in Nutrition, 9, 984622. https://doi.org/10.3389/fnut.2022.984622
Noori S, et al. Does the Mediterranean Diet Reduce the Odds of Diabetic Nephropathy in Women? a Case-control Study. Front Nutr. 2022;9:984622. PubMed PMID: 36118745.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does the Mediterranean diet reduce the odds of diabetic nephropathy in women? A case-control study. AU - Noori,Sahar, AU - Mirzababaei,Atieh, AU - Abaj,Faezeh, AU - Ghaffarian-Ensaf,Rasool, AU - Mirzaei,Khadijeh, Y1 - 2022/09/02/ PY - 2022/07/02/received PY - 2022/08/12/accepted PY - 2022/9/19/entrez PY - 2022/9/20/pubmed PY - 2022/9/20/medline KW - Mediterranean diet KW - case-control KW - diabetes KW - diabetic nephropathy KW - women SP - 984622 EP - 984622 JF - Frontiers in nutrition JO - Front Nutr VL - 9 N2 - Background: In recent decades, the prevalence of chronic diseases such as diabetes is increasing. One of the major complications of diabetes is diabetic nephropathy (DN), so it is important to find a way that can delay or control the onset of DN. Therefore, in this study, we investigated the relationship between the Mediterranean diet (MED) and the odds of DN. Methods: This case-control study was performed among 210 women (30-65 years) who were referred to the Kowsar Diabetes Clinic in Semnan, Iran. Biochemical variables and anthropometric measurements were assessed. The food frequency questionnaire (FFQ) was used to calculate dietary intakes. Data from dietary intakes based on the FFQ were used to evaluate the MED score. Logistic regression was used to examine the associations. Results: Our results showed that in the crude model with higher adherence to the MED (OR: 0.272; 95% CI: 0.154, 0.481; P = 0.001), the odds of DN has reduced by 73%, and in model 1, after controlling for potential confounders, with higher adherence to the MED (OR: 0.239; 95% CI: 0.128, 0.447; P = 0.001), the odds of DN has reduced by 76% compared to low adherence. Also, in model 1, significant associations were observed between high consumption of grains (OR: 0.360; 95% CI: 0.191, 0.676; P = 0.001), legumes (OR: 0.156; 95% CI: 0.083, 0.292; P = 0.001), vegetables (OR: 0.273; 95% CI: 0.149, 0.501; P = 0.001), fruits (OR: 0.179; 95% CI: 0.093, 0.347; P = 0.001), fish (OR: 0.459; 95% CI: 0.254, 0.827; P = 0.01), and reduced odds of DN (P < 0.05). Conclusion: We observed that with higher adherence to the MED, the odds of DN had reduced through mechanisms. However, additional studies are needed to confirm these findings. SN - 2296-861X UR - https://www.unboundmedicine.com/medline/citation/36118745/Does_the_Mediterranean_diet_reduce_the_odds_of_diabetic_nephropathy_in_women_A_case_control_study_ L2 - https://doi.org/10.3389/fnut.2022.984622 DB - PRIME DP - Unbound Medicine ER -
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