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Mechanisms of endocochlear potential generation by stria vascularis.
Laryngoscope. 1987 Aug; 97(8 Pt 1):984-91.L

Abstract

It is commonly accepted that the endocochlear potential (EP) of the cochlea is generated by an electrogenic transport of potassium into scala media by the marginal cells of stria vascularis. We have studied the potential and potassium concentration gradients as stria vascularis was penetrated with double-barreled potassium selective electrodes in the guinea pig cochlea. Our data demonstrate that a region exists in stria which is positively polarized (higher than the EP), but which has a low (perilymph-like) potassium composition. It is concluded that EP cannot be generated by the marginal cells alone but may involve passive potassium movement across the apical membranes of the basal cells. A model is presented which is consistent with many anatomical and physiological features of stria vascularis.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3613802

Citation

Salt, A N., et al. "Mechanisms of Endocochlear Potential Generation By Stria Vascularis." The Laryngoscope, vol. 97, no. 8 Pt 1, 1987, pp. 984-91.
Salt AN, Melichar I, Thalmann R. Mechanisms of endocochlear potential generation by stria vascularis. Laryngoscope. 1987;97(8 Pt 1):984-91.
Salt, A. N., Melichar, I., & Thalmann, R. (1987). Mechanisms of endocochlear potential generation by stria vascularis. The Laryngoscope, 97(8 Pt 1), 984-91.
Salt AN, Melichar I, Thalmann R. Mechanisms of Endocochlear Potential Generation By Stria Vascularis. Laryngoscope. 1987;97(8 Pt 1):984-91. PubMed PMID: 3613802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms of endocochlear potential generation by stria vascularis. AU - Salt,A N, AU - Melichar,I, AU - Thalmann,R, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 984 EP - 91 JF - The Laryngoscope JO - Laryngoscope VL - 97 IS - 8 Pt 1 N2 - It is commonly accepted that the endocochlear potential (EP) of the cochlea is generated by an electrogenic transport of potassium into scala media by the marginal cells of stria vascularis. We have studied the potential and potassium concentration gradients as stria vascularis was penetrated with double-barreled potassium selective electrodes in the guinea pig cochlea. Our data demonstrate that a region exists in stria which is positively polarized (higher than the EP), but which has a low (perilymph-like) potassium composition. It is concluded that EP cannot be generated by the marginal cells alone but may involve passive potassium movement across the apical membranes of the basal cells. A model is presented which is consistent with many anatomical and physiological features of stria vascularis. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/3613802/Mechanisms_of_endocochlear_potential_generation_by_stria_vascularis_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0023-852X&date=1987&volume=97&issue=8 Pt 1&spage=984 DB - PRIME DP - Unbound Medicine ER -