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Effects of methyl acetyl phosphate on hemoglobin S: a novel acetylating agent directed towards the DPG binding site.
Prog Clin Biol Res. 1987; 240:105-10.PC

Abstract

Methyl acetyl phosphate (MAP) is an acetylating agent which prevents the polymerization of sickle cell hemoglobin (HbS). MAP can penetrate sickle erythrocytes and can acetylate intracellular HbS. Tryptic peptide mapping of modified HbS on reversed phase HPLC and amino acid analysis of isolated peptides revealed the acetylation sites to be Val-1 (beta), Lys-82 (beta), and Lys-144 (beta). MAP, therefore, is specifically directed towards the 2,3-DPG binding site of Hb.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3615481

Citation

Ueno, H, et al. "Effects of Methyl Acetyl Phosphate On Hemoglobin S: a Novel Acetylating Agent Directed Towards the DPG Binding Site." Progress in Clinical and Biological Research, vol. 240, 1987, pp. 105-10.
Ueno H, Benjamin LJ, Manning JM. Effects of methyl acetyl phosphate on hemoglobin S: a novel acetylating agent directed towards the DPG binding site. Prog Clin Biol Res. 1987;240:105-10.
Ueno, H., Benjamin, L. J., & Manning, J. M. (1987). Effects of methyl acetyl phosphate on hemoglobin S: a novel acetylating agent directed towards the DPG binding site. Progress in Clinical and Biological Research, 240, 105-10.
Ueno H, Benjamin LJ, Manning JM. Effects of Methyl Acetyl Phosphate On Hemoglobin S: a Novel Acetylating Agent Directed Towards the DPG Binding Site. Prog Clin Biol Res. 1987;240:105-10. PubMed PMID: 3615481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of methyl acetyl phosphate on hemoglobin S: a novel acetylating agent directed towards the DPG binding site. AU - Ueno,H, AU - Benjamin,L J, AU - Manning,J M, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 105 EP - 10 JF - Progress in clinical and biological research JO - Prog Clin Biol Res VL - 240 N2 - Methyl acetyl phosphate (MAP) is an acetylating agent which prevents the polymerization of sickle cell hemoglobin (HbS). MAP can penetrate sickle erythrocytes and can acetylate intracellular HbS. Tryptic peptide mapping of modified HbS on reversed phase HPLC and amino acid analysis of isolated peptides revealed the acetylation sites to be Val-1 (beta), Lys-82 (beta), and Lys-144 (beta). MAP, therefore, is specifically directed towards the 2,3-DPG binding site of Hb. SN - 0361-7742 UR - https://www.unboundmedicine.com/medline/citation/3615481/Effects_of_methyl_acetyl_phosphate_on_hemoglobin_S:_a_novel_acetylating_agent_directed_towards_the_DPG_binding_site_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:3615481 DB - PRIME DP - Unbound Medicine ER -