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The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank.
Eur J Prev Cardiol. 2022 12 07; 29(17):2240-2249.EJ

Abstract

AIMS

Epidemiological studies report the beneficial effects of habitual coffee consumption on incident arrhythmia, cardiovascular disease (CVD), and mortality. However, the impact of different coffee preparations on cardiovascular outcomes and survival is largely unknown. The aim of this study was to evaluate associations between coffee subtypes on incident outcomes, utilizing the UK Biobank.

METHODS AND RESULTS

Coffee subtypes were defined as decaffeinated, ground, and instant, then divided into 0, <1, 1, 2-3, 4-5, and >5 cups/day, and compared with non-drinkers. Cardiovascular disease included coronary heart disease, cardiac failure, and ischaemic stroke. Cox regression modelling with hazard ratios (HRs) assessed associations with incident arrhythmia, CVD, and mortality. Outcomes were determined through ICD codes and death records. A total of 449 563 participants (median 58 years, 55.3% females) were followed over 12.5 ± 0.7 years. Ground and instant coffee consumption was associated with a significant reduction in arrhythmia at 1-5 cups/day but not for decaffeinated coffee. The lowest risk was 4-5 cups/day for ground coffee [HR 0.83, confidence interval (CI) 0.76-0.91, P < 0.0001] and 2-3 cups/day for instant coffee (HR 0.88, CI 0.85-0.92, P < 0.0001). All coffee subtypes were associated with a reduction in incident CVD (the lowest risk was 2-3 cups/day for decaffeinated, P = 0.0093; ground, P < 0.0001; and instant coffee, P < 0.0001) vs. non-drinkers. All-cause mortality was significantly reduced for all coffee subtypes, with the greatest risk reduction seen with 2-3 cups/day for decaffeinated (HR 0.86, CI 0.81-0.91, P < 0.0001); ground (HR 0.73, CI 0.69-0.78, P < 0.0001); and instant coffee (HR 0.89, CI 0.86-0.93, P < 0.0001).

CONCLUSION

Decaffeinated, ground, and instant coffee, particularly at 2-3 cups/day, were associated with significant reductions in incident CVD and mortality. Ground and instant but not decaffeinated coffee was associated with reduced arrhythmia.

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Authors+Show Affiliations

Chieng D
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Canovas R
Cambridge Baker Systems Genomics Initiaive, 75 Commercial Road, Melbourne 3004, Australia. Baker Department of Cardiometabolic Health, 75 Commercial Road, Melbourne 3004, Australia.
Segan L
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Sugumar H
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Voskoboinik A
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Prabhu S
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Ling LH
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia.
Lee G
Department of Medicine, University of Melbourne, Parkville 3010, Australia. Royal Melbourne Hospital, 300 Grattan Street, Melbourne 3010, Australia.
Morton JB
Department of Medicine, University of Melbourne, Parkville 3010, Australia. Royal Melbourne Hospital, 300 Grattan Street, Melbourne 3010, Australia.
Kaye DM
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, Faculty of Medicine, Monash University, Melbourne 3800, Australia.
Kalman JM
Department of Medicine, University of Melbourne, Parkville 3010, Australia. Royal Melbourne Hospital, 300 Grattan Street, Melbourne 3010, Australia. Department of Medicine, Faculty of Medicine, Monash University, Melbourne 3800, Australia.
Kistler PM
Clinical Electrophysiology Research Laboratory, Baker Heart and Diabetes Research Institute, 55 Commercial Road, Melbourne 3004, Australia. Department of Cardiology, Alfred Hospital, 55 Commercial Road, Melbourne 3004, Australia. Department of Medicine, University of Melbourne, Parkville 3010, Australia. Department of Medicine, Faculty of Medicine, Monash University, Melbourne 3800, Australia.

MeSH

HumansCardiovascular DiseasesCoffeeBiological Specimen BanksBrain IschemiaStrokeUnited Kingdom

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36162818

Citation

Chieng, David, et al. "The Impact of Coffee Subtypes On Incident Cardiovascular Disease, Arrhythmias, and Mortality: Long-term Outcomes From the UK Biobank." European Journal of Preventive Cardiology, vol. 29, no. 17, 2022, pp. 2240-2249.
Chieng D, Canovas R, Segan L, et al. The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank. Eur J Prev Cardiol. 2022;29(17):2240-2249.
Chieng, D., Canovas, R., Segan, L., Sugumar, H., Voskoboinik, A., Prabhu, S., Ling, L. H., Lee, G., Morton, J. B., Kaye, D. M., Kalman, J. M., & Kistler, P. M. (2022). The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank. European Journal of Preventive Cardiology, 29(17), 2240-2249. https://doi.org/10.1093/eurjpc/zwac189
Chieng D, et al. The Impact of Coffee Subtypes On Incident Cardiovascular Disease, Arrhythmias, and Mortality: Long-term Outcomes From the UK Biobank. Eur J Prev Cardiol. 2022 12 7;29(17):2240-2249. PubMed PMID: 36162818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of coffee subtypes on incident cardiovascular disease, arrhythmias, and mortality: long-term outcomes from the UK Biobank. AU - Chieng,David, AU - Canovas,Rodrigo, AU - Segan,Louise, AU - Sugumar,Hariharan, AU - Voskoboinik,Aleksandr, AU - Prabhu,Sandeep, AU - Ling,Liang-Han, AU - Lee,Geoffrey, AU - Morton,Joseph B, AU - Kaye,David M, AU - Kalman,Jonathan M, AU - Kistler,Peter M, PY - 2022/06/13/received PY - 2022/08/09/revised PY - 2022/08/24/accepted PY - 2022/9/27/pubmed PY - 2022/12/15/medline PY - 2022/9/26/entrez KW - Arrhythmia KW - Cardiovascular disease KW - Coffee KW - Congestive cardiac failure KW - Coronary heart disease KW - Decaffeinated KW - Ground KW - Instant KW - Stroke SP - 2240 EP - 2249 JF - European journal of preventive cardiology JO - Eur J Prev Cardiol VL - 29 IS - 17 N2 - AIMS: Epidemiological studies report the beneficial effects of habitual coffee consumption on incident arrhythmia, cardiovascular disease (CVD), and mortality. However, the impact of different coffee preparations on cardiovascular outcomes and survival is largely unknown. The aim of this study was to evaluate associations between coffee subtypes on incident outcomes, utilizing the UK Biobank. METHODS AND RESULTS: Coffee subtypes were defined as decaffeinated, ground, and instant, then divided into 0, <1, 1, 2-3, 4-5, and >5 cups/day, and compared with non-drinkers. Cardiovascular disease included coronary heart disease, cardiac failure, and ischaemic stroke. Cox regression modelling with hazard ratios (HRs) assessed associations with incident arrhythmia, CVD, and mortality. Outcomes were determined through ICD codes and death records. A total of 449 563 participants (median 58 years, 55.3% females) were followed over 12.5 ± 0.7 years. Ground and instant coffee consumption was associated with a significant reduction in arrhythmia at 1-5 cups/day but not for decaffeinated coffee. The lowest risk was 4-5 cups/day for ground coffee [HR 0.83, confidence interval (CI) 0.76-0.91, P < 0.0001] and 2-3 cups/day for instant coffee (HR 0.88, CI 0.85-0.92, P < 0.0001). All coffee subtypes were associated with a reduction in incident CVD (the lowest risk was 2-3 cups/day for decaffeinated, P = 0.0093; ground, P < 0.0001; and instant coffee, P < 0.0001) vs. non-drinkers. All-cause mortality was significantly reduced for all coffee subtypes, with the greatest risk reduction seen with 2-3 cups/day for decaffeinated (HR 0.86, CI 0.81-0.91, P < 0.0001); ground (HR 0.73, CI 0.69-0.78, P < 0.0001); and instant coffee (HR 0.89, CI 0.86-0.93, P < 0.0001). CONCLUSION: Decaffeinated, ground, and instant coffee, particularly at 2-3 cups/day, were associated with significant reductions in incident CVD and mortality. Ground and instant but not decaffeinated coffee was associated with reduced arrhythmia. SN - 2047-4881 UR - https://www.unboundmedicine.com/medline/citation/36162818/The_impact_of_coffee_subtypes_on_incident_cardiovascular_disease_arrhythmias_and_mortality:_long_term_outcomes_from_the_UK_Biobank_ DB - PRIME DP - Unbound Medicine ER -