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Red blood cell zinc protoporphyrin testing for iron-deficiency anemia in pregnancy.
Am J Obstet Gynecol. 1987 Aug; 157(2):304-7.AJ

Abstract

The diagnostic value of ferritin, transferrin saturation, and red blood cell zinc protoporphyrin for detecting iron depletion and predicting third-trimester anemia was studied in 87 women attending a private obstetrics clinic. A decline in ferritin and transferrin saturation and an increase in red blood cell zinc protoporphyrin levels were observed in third-trimester measurements when compared with those of the first trimester. Third-trimester anemia (hemoglobin less than 11.5 gm/dl or 115 gm/L) was detected in 13 (15%) women. Red blood cell zinc protoporphyrin was the only test that consistently demonstrated significantly different mean values between anemic and normal subgroups. The diagnostic sensitivity and predictive value of red blood cell zinc protoporphyrin for evaluating iron depletion and risk of anemia in pregnancy compared favorably to those of ferritin and transferrin saturation measurements. The operational simplicity and low cost of red blood cell zinc protoporphyrin measurements are additional characteristics that favor this procedure for office testing.

Authors

Schifman RB
No affiliation info available
Thomasson JE
No affiliation info available
Evers JM
No affiliation info available

MeSH

Anemia, HypochromicErythrocytesFemaleFerritinsHumansPorphyrinsPregnancyPregnancy Complications, HematologicProtoporphyrinsTransferrin

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3618677

Citation

Schifman, R B., et al. "Red Blood Cell Zinc Protoporphyrin Testing for Iron-deficiency Anemia in Pregnancy." American Journal of Obstetrics and Gynecology, vol. 157, no. 2, 1987, pp. 304-7.
Schifman RB, Thomasson JE, Evers JM. Red blood cell zinc protoporphyrin testing for iron-deficiency anemia in pregnancy. Am J Obstet Gynecol. 1987;157(2):304-7.
Schifman, R. B., Thomasson, J. E., & Evers, J. M. (1987). Red blood cell zinc protoporphyrin testing for iron-deficiency anemia in pregnancy. American Journal of Obstetrics and Gynecology, 157(2), 304-7.
Schifman RB, Thomasson JE, Evers JM. Red Blood Cell Zinc Protoporphyrin Testing for Iron-deficiency Anemia in Pregnancy. Am J Obstet Gynecol. 1987;157(2):304-7. PubMed PMID: 3618677.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red blood cell zinc protoporphyrin testing for iron-deficiency anemia in pregnancy. AU - Schifman,R B, AU - Thomasson,J E, AU - Evers,J M, PY - 1987/8/1/pubmed PY - 1987/8/1/medline PY - 1987/8/1/entrez SP - 304 EP - 7 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 157 IS - 2 N2 - The diagnostic value of ferritin, transferrin saturation, and red blood cell zinc protoporphyrin for detecting iron depletion and predicting third-trimester anemia was studied in 87 women attending a private obstetrics clinic. A decline in ferritin and transferrin saturation and an increase in red blood cell zinc protoporphyrin levels were observed in third-trimester measurements when compared with those of the first trimester. Third-trimester anemia (hemoglobin less than 11.5 gm/dl or 115 gm/L) was detected in 13 (15%) women. Red blood cell zinc protoporphyrin was the only test that consistently demonstrated significantly different mean values between anemic and normal subgroups. The diagnostic sensitivity and predictive value of red blood cell zinc protoporphyrin for evaluating iron depletion and risk of anemia in pregnancy compared favorably to those of ferritin and transferrin saturation measurements. The operational simplicity and low cost of red blood cell zinc protoporphyrin measurements are additional characteristics that favor this procedure for office testing. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/3618677/Red_blood_cell_zinc_protoporphyrin_testing_for_iron_deficiency_anemia_in_pregnancy_ DB - PRIME DP - Unbound Medicine ER -