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Reduced albuminuria after dietary protein restriction in insulin-dependent diabetic patients with clinical nephropathy.
Diabetes Care. 1987 Jul-Aug; 10(4):407-13.DC

Abstract

Recent clinical investigations have demonstrated that an early restriction of dietary protein intake may reduce the rate of progression of chronic renal failure in humans. In this study the effects of a restricted-protein diet on kidney function in type I diabetic patients with clinical nephropathy were evaluated. Sixteen patients (9 men, 7 women) with mean age 37.1 +/- 9.8 yr, mean duration of diabetes 17.7 +/- 6.6 yr, proteinuria greater than 0.5 g/24 h, and serum creatinine concentration of 0.7-1.9 mg/dl were studied. Patients were randomly divided into two groups. The low-protein diet (LPD) group comprised seven patients who were kept for 4.5 +/- 1 mo on a diet containing 0.71 +/- 0.12 g X kg-1 X day-1 protein. The normal-protein diet (NPD) group comprised nine patients as controls maintained for 11.7 +/- 7 mo on their usual diabetic diet containing 1.44 +/- 0.12 g X kg-1 X day-1 protein. All patients were studied every 1-2 mo. Metabolic control was assessed by evaluation of 5-8 blood glucose determinations/day and by glycosylated hemoglobin, whereas renal function was evaluated by albumin, IgG and beta 2-microglobulin urinary excretion rates, serum creatinine concentration, and creatinine clearance. At each visit, serum concentrations of total protein, albumin, phosphate, calcium, and electrolytes and weight and blood pressure were also measured. A significant reduction (434 +/- 244 to 205 +/- 212 micrograms/min, mean +/- SD) in albumin excretion rate was found in all LPD patients after dietary protein restriction, with a significant reincrease (689 +/- 201 micrograms/min) in the same patients several months after interruption of diet.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors

Ciavarella A
No affiliation info available
Di Mizio G
No affiliation info available
Stefoni S
No affiliation info available
Borgnino LC
No affiliation info available
Vannini P
No affiliation info available

MeSH

AdultAlbuminuriaBlood GlucoseDiabetes Mellitus, Type 1Diabetic NephropathiesDietary ProteinsFemaleHumansKidneyKidney Failure, ChronicMaleMiddle AgedRandom Allocation

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3622197

Citation

Ciavarella, A, et al. "Reduced Albuminuria After Dietary Protein Restriction in Insulin-dependent Diabetic Patients With Clinical Nephropathy." Diabetes Care, vol. 10, no. 4, 1987, pp. 407-13.
Ciavarella A, Di Mizio G, Stefoni S, et al. Reduced albuminuria after dietary protein restriction in insulin-dependent diabetic patients with clinical nephropathy. Diabetes Care. 1987;10(4):407-13.
Ciavarella, A., Di Mizio, G., Stefoni, S., Borgnino, L. C., & Vannini, P. (1987). Reduced albuminuria after dietary protein restriction in insulin-dependent diabetic patients with clinical nephropathy. Diabetes Care, 10(4), 407-13.
Ciavarella A, et al. Reduced Albuminuria After Dietary Protein Restriction in Insulin-dependent Diabetic Patients With Clinical Nephropathy. Diabetes Care. 1987 Jul-Aug;10(4):407-13. PubMed PMID: 3622197.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduced albuminuria after dietary protein restriction in insulin-dependent diabetic patients with clinical nephropathy. AU - Ciavarella,A, AU - Di Mizio,G, AU - Stefoni,S, AU - Borgnino,L C, AU - Vannini,P, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 407 EP - 13 JF - Diabetes care JO - Diabetes Care VL - 10 IS - 4 N2 - Recent clinical investigations have demonstrated that an early restriction of dietary protein intake may reduce the rate of progression of chronic renal failure in humans. In this study the effects of a restricted-protein diet on kidney function in type I diabetic patients with clinical nephropathy were evaluated. Sixteen patients (9 men, 7 women) with mean age 37.1 +/- 9.8 yr, mean duration of diabetes 17.7 +/- 6.6 yr, proteinuria greater than 0.5 g/24 h, and serum creatinine concentration of 0.7-1.9 mg/dl were studied. Patients were randomly divided into two groups. The low-protein diet (LPD) group comprised seven patients who were kept for 4.5 +/- 1 mo on a diet containing 0.71 +/- 0.12 g X kg-1 X day-1 protein. The normal-protein diet (NPD) group comprised nine patients as controls maintained for 11.7 +/- 7 mo on their usual diabetic diet containing 1.44 +/- 0.12 g X kg-1 X day-1 protein. All patients were studied every 1-2 mo. Metabolic control was assessed by evaluation of 5-8 blood glucose determinations/day and by glycosylated hemoglobin, whereas renal function was evaluated by albumin, IgG and beta 2-microglobulin urinary excretion rates, serum creatinine concentration, and creatinine clearance. At each visit, serum concentrations of total protein, albumin, phosphate, calcium, and electrolytes and weight and blood pressure were also measured. A significant reduction (434 +/- 244 to 205 +/- 212 micrograms/min, mean +/- SD) in albumin excretion rate was found in all LPD patients after dietary protein restriction, with a significant reincrease (689 +/- 201 micrograms/min) in the same patients several months after interruption of diet.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0149-5992 UR - https://www.unboundmedicine.com/medline/citation/3622197/Reduced_albuminuria_after_dietary_protein_restriction_in_insulin_dependent_diabetic_patients_with_clinical_nephropathy_ DB - PRIME DP - Unbound Medicine ER -