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Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology.
J Alzheimers Dis. 2022; 90(3):1329-1337.JA

Abstract

BACKGROUND

Reduced signal on fluorodeoxyglucose-positron emission tomography (FDG-PET) is a valid proxy for neurodegeneration in Alzheimer's disease (AD). Perivascular space (PVS) is believed to be associated with AD pathology and cognitive decline.

OBJECTIVE

This study aimed to investigate the associations of PVS with FDG-PET and cognitive performance based on the burden of amyloid pathology.

METHODS

We used magnetic resonance imaging (MRI) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). MRI-visible PVS in basal ganglia (BG) and centrum semi-oval (CSO) were visually classified as: none/mild, moderate or frequent/severe. The association of PVS with brain FDG-PET was explored based on the burden of amyloid pathology, where a cerebrospinal fluid (CSF) t-tau/Aβ42 with the ratio≥0.27 was defined as high amyloid pathology. Moreover, the relationships between PVS and cognitive performance variables (ADNI-MEM and ADNI-EF) were studied.

RESULTS

For participants with higher tau/Aβ42 ratio, CSO-PVS severity was independently associated with lower FDG-PET. There were significant interaction effects between moderate or frequent/severe CSO-PVS and time on FDG decline in people with high amyloid pathology. The interaction between CSO-PVS and time (follow-up) was consistently associated with ADNI-MEM and ADNI-EF decline in individuals with high amyloid pathology.

CONCLUSION

The study established the differential utility of PVS in BG and CSO for predicting brain metabolism. These findings suggest that CSO-PVS serves as a contributing factor to brain metabolism and cognitive decline associated with amyloid pathology.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Shi X
Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China.
Zhou N
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Sun B
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Wu Y
The Department of Radiology, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China.
Hu Y
Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China.
Ning Y
Geriatric Neuroscience Center, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China. Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. The First School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Alzheimer’s Disease Neuroimaging Initiative
No affiliation info available

MeSH

HumansAlzheimer DiseaseFluorodeoxyglucose F18BrainNeuroimagingCognitive DysfunctionPositron-Emission TomographyMagnetic Resonance ImagingAmyloidogenic ProteinsAmyloidosisAmyloid beta-PeptidesBiomarkers

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36245373

Citation

Shi, Xiaolei, et al. "Perivascular Space Predicts Brain Hypometabolism of Individuals With Underlying Amyloid Pathology." Journal of Alzheimer's Disease : JAD, vol. 90, no. 3, 2022, pp. 1329-1337.
Shi X, Zhou N, Sun B, et al. Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology. J Alzheimers Dis. 2022;90(3):1329-1337.
Shi, X., Zhou, N., Sun, B., Wu, Y., Hu, Y., & Ning, Y. (2022). Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology. Journal of Alzheimer's Disease : JAD, 90(3), 1329-1337. https://doi.org/10.3233/JAD-220426
Shi X, et al. Perivascular Space Predicts Brain Hypometabolism of Individuals With Underlying Amyloid Pathology. J Alzheimers Dis. 2022;90(3):1329-1337. PubMed PMID: 36245373.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Perivascular Space Predicts Brain Hypometabolism of Individuals with Underlying Amyloid Pathology. AU - Shi,Xiaolei, AU - Zhou,Nan, AU - Sun,Bin, AU - Wu,Yongshun, AU - Hu,Yachun, AU - Ning,Yuping, AU - ,, PY - 2022/10/18/pubmed PY - 2022/12/1/medline PY - 2022/10/17/entrez KW - Amyloid KW - basal ganglia KW - centrum semi-oval KW - metabolism KW - perivascular space SP - 1329 EP - 1337 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 90 IS - 3 N2 - BACKGROUND: Reduced signal on fluorodeoxyglucose-positron emission tomography (FDG-PET) is a valid proxy for neurodegeneration in Alzheimer's disease (AD). Perivascular space (PVS) is believed to be associated with AD pathology and cognitive decline. OBJECTIVE: This study aimed to investigate the associations of PVS with FDG-PET and cognitive performance based on the burden of amyloid pathology. METHODS: We used magnetic resonance imaging (MRI) data from the Alzheimer's Disease Neuroimaging Initiative (ADNI). MRI-visible PVS in basal ganglia (BG) and centrum semi-oval (CSO) were visually classified as: none/mild, moderate or frequent/severe. The association of PVS with brain FDG-PET was explored based on the burden of amyloid pathology, where a cerebrospinal fluid (CSF) t-tau/Aβ42 with the ratio≥0.27 was defined as high amyloid pathology. Moreover, the relationships between PVS and cognitive performance variables (ADNI-MEM and ADNI-EF) were studied. RESULTS: For participants with higher tau/Aβ42 ratio, CSO-PVS severity was independently associated with lower FDG-PET. There were significant interaction effects between moderate or frequent/severe CSO-PVS and time on FDG decline in people with high amyloid pathology. The interaction between CSO-PVS and time (follow-up) was consistently associated with ADNI-MEM and ADNI-EF decline in individuals with high amyloid pathology. CONCLUSION: The study established the differential utility of PVS in BG and CSO for predicting brain metabolism. These findings suggest that CSO-PVS serves as a contributing factor to brain metabolism and cognitive decline associated with amyloid pathology. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/36245373/Perivascular_Space_Predicts_Brain_Hypometabolism_of_Individuals_with_Underlying_Amyloid_Pathology_ DB - PRIME DP - Unbound Medicine ER -