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Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension.
Comput Math Methods Med. 2022; 2022:9317114.CM

Abstract

Objective

The purpose is to investigate the influence of nifedipine, labetalol, and magnesium sulfate on blood pressure control, blood coagulation, and maternal and infant outcome in those suffering from pregnancy-induced hypertension (PIH).

Methods

From January 2019 to April 2021, 100 participants with PIH in our center were randomly assigned to a control group and a research group. As a control, nifedipine combined with magnesium sulfate was administered. Nifedipine, labetalol, and magnesium sulfate were administered to the research group. The curative effect, blood pressure level, blood coagulation function, vascular endothelial function, and pregnancy comparisons were made between the two groups.

Results

Based on the results of the study, the effective rate totaled 92.00%, while as for the control group, it was 80.0%, which indicates that there was a statistically significant difference between the effective rates of the research group and that of the control group, and the difference was statistically significant (P < 0.05). Blood pressure and blood coagulation function did not differ significantly between the two groups before treatment, and the difference was not statistically significant (P > 0.05). After treatment, both groups experienced a significant drop in systolic and diastolic blood pressure. After treatment, a higher PT index was found in the research group than in the control group. Likewise, the Fbg, D-D, and PLT were lower compared to those in the control group, and the difference was statistically significant (P < 0.05). Neither group had significantly different vascular endothelial function before treatment, and the difference was not statistically significant (P > 0.05). After treatment, the ET-1 of the two groups decreased, and the level of NO increased. There was a lower ET-1 in the research group than in the control group as well as a higher NO level in the research group than in the control group, and the difference was statistically significant (P < 0.05). Compared with the pregnancy outcome, in comparison to the controls, the research group had a higher vaginal delivery rate. Significantly, fewer cases of fetal distress, intrauterine asphyxia, and placental abruption were reported in the research group than in the control group, and the difference was statistically significant (P < 0.05).

Conclusion

Nifedipine, in combination with magnesium sulfate and labetalol, is effective at treating PIH, reducing blood pressure, improving blood coagulation, preventing cardiovascular events and vascular endothelial function, and further improve the pregnancy outcome.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.Department of Obstetrics and Gynecology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.Department of Obstetrics and Gynecology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai 201700, China.

Pub Type(s)

Randomized Controlled Trial
Journal Article

Language

eng

PubMed ID

36277012

Citation

Shao, Yuping, et al. "Effects of Nifedipine and Labetalol Combined With Magnesium Sulfate On Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients With Pregnancy-Induced Hypertension." Computational and Mathematical Methods in Medicine, vol. 2022, 2022, p. 9317114.
Shao Y, Gu S, Zhang X. Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension. Comput Math Methods Med. 2022;2022:9317114.
Shao, Y., Gu, S., & Zhang, X. (2022). Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension. Computational and Mathematical Methods in Medicine, 2022, 9317114. https://doi.org/10.1155/2022/9317114
Shao Y, Gu S, Zhang X. Effects of Nifedipine and Labetalol Combined With Magnesium Sulfate On Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients With Pregnancy-Induced Hypertension. Comput Math Methods Med. 2022;2022:9317114. PubMed PMID: 36277012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Nifedipine and Labetalol Combined with Magnesium Sulfate on Blood Pressure Control, Blood Coagulation Function, and Maternal and Infant Outcome in Patients with Pregnancy-Induced Hypertension. AU - Shao,Yuping, AU - Gu,Siyi, AU - Zhang,Xiaoping, Y1 - 2022/10/13/ PY - 2022/08/03/received PY - 2022/08/11/revised PY - 2022/08/27/accepted PY - 2022/10/24/entrez PY - 2022/10/25/pubmed PY - 2022/10/26/medline SP - 9317114 EP - 9317114 JF - Computational and mathematical methods in medicine JO - Comput Math Methods Med VL - 2022 N2 - Objective: The purpose is to investigate the influence of nifedipine, labetalol, and magnesium sulfate on blood pressure control, blood coagulation, and maternal and infant outcome in those suffering from pregnancy-induced hypertension (PIH). Methods: From January 2019 to April 2021, 100 participants with PIH in our center were randomly assigned to a control group and a research group. As a control, nifedipine combined with magnesium sulfate was administered. Nifedipine, labetalol, and magnesium sulfate were administered to the research group. The curative effect, blood pressure level, blood coagulation function, vascular endothelial function, and pregnancy comparisons were made between the two groups. Results: Based on the results of the study, the effective rate totaled 92.00%, while as for the control group, it was 80.0%, which indicates that there was a statistically significant difference between the effective rates of the research group and that of the control group, and the difference was statistically significant (P < 0.05). Blood pressure and blood coagulation function did not differ significantly between the two groups before treatment, and the difference was not statistically significant (P > 0.05). After treatment, both groups experienced a significant drop in systolic and diastolic blood pressure. After treatment, a higher PT index was found in the research group than in the control group. Likewise, the Fbg, D-D, and PLT were lower compared to those in the control group, and the difference was statistically significant (P < 0.05). Neither group had significantly different vascular endothelial function before treatment, and the difference was not statistically significant (P > 0.05). After treatment, the ET-1 of the two groups decreased, and the level of NO increased. There was a lower ET-1 in the research group than in the control group as well as a higher NO level in the research group than in the control group, and the difference was statistically significant (P < 0.05). Compared with the pregnancy outcome, in comparison to the controls, the research group had a higher vaginal delivery rate. Significantly, fewer cases of fetal distress, intrauterine asphyxia, and placental abruption were reported in the research group than in the control group, and the difference was statistically significant (P < 0.05). Conclusion: Nifedipine, in combination with magnesium sulfate and labetalol, is effective at treating PIH, reducing blood pressure, improving blood coagulation, preventing cardiovascular events and vascular endothelial function, and further improve the pregnancy outcome. SN - 1748-6718 UR - https://www.unboundmedicine.com/medline/citation/36277012/Effects_of_Nifedipine_and_Labetalol_Combined_with_Magnesium_Sulfate_on_Blood_Pressure_Control,_Blood_Coagulation_Function,_and_Maternal_and_Infant_Outcome_in_Patients_with_Pregnancy-Induced_Hypertension. DB - PRIME DP - Unbound Medicine ER -