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From Small Peptides to Large Proteins against Alzheimer'sDisease.
Biomolecules. 2022 Sep 22; 12(10)B

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented.

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Authors+Show Affiliations

Picone P
Istituto per la Ricerca e l'Innovazione Biomedica, Consiglio Nazionale delle Ricerche, Via U. La Malfa 153, 90146 Palermo, Italy. Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Sanfilippo T
Ambulatorio di Nutrizione Clinica ASP Palermo, Via G. Cusmano 24, 90141 Palermo, Italy. Anestesia e Rianimazione, Presidio Ospedaliero "S. Cimino", 90141 Termini Imerese, Italy.
Vasto S
Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, 90128 Palermo, Italy. Istituti Euro-Mediterranei di Scienza e Tecnologia (IEMEST), Via M. Miraglia 20, 90139 Palermo, Italy.
Baldassano S
Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Guggino R
Ambulatorio di Nutrizione Clinica ASP Palermo, Via G. Cusmano 24, 90141 Palermo, Italy. Anestesia e Rianimazione, Presidio Ospedaliero "S. Cimino", 90141 Termini Imerese, Italy.
Nuzzo D
Istituto per la Ricerca e l'Innovazione Biomedica, Consiglio Nazionale delle Ricerche, Via U. La Malfa 153, 90146 Palermo, Italy. Dipartmento of Scienze Biologiche, Chimiche, Farmaceutiche e Tecnologiche (STEBICEF), University of Palermo, 90128 Palermo, Italy.
Bulone D
Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via U. La. Malfa 153, 90146 Palermo, Italy.
San Biagio PL
Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via U. La. Malfa 153, 90146 Palermo, Italy.
Muscolino E
Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, 90128 Palermo, Italy.
Monastero R
Dipartimento di Biomedicina, Neuroscienze e Diagnostica Avanzata, Università degli Studi di Palermo, Via del Vespro 129, 90127 Palermo, Italy.
Dispenza C
Dipartimento di Ingegneria, Università degli Studi di Palermo, Viale delle Scienze, Bldg 6, 90128 Palermo, Italy.
Giacomazza D
Istituto di Biofisica, Consiglio Nazionale delle Ricerche, Via U. La. Malfa 153, 90146 Palermo, Italy.

MeSH

HumansAgedAlzheimer Diseasetau ProteinsAmyloid beta-PeptidesPlaque, AmyloidNeuronsNeurofibrillary Tangles

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36291553

Citation

Picone, Pasquale, et al. "From Small Peptides to Large Proteins Against Alzheimer'sDisease." Biomolecules, vol. 12, no. 10, 2022.
Picone P, Sanfilippo T, Vasto S, et al. From Small Peptides to Large Proteins against Alzheimer'sDisease. Biomolecules. 2022;12(10).
Picone, P., Sanfilippo, T., Vasto, S., Baldassano, S., Guggino, R., Nuzzo, D., Bulone, D., San Biagio, P. L., Muscolino, E., Monastero, R., Dispenza, C., & Giacomazza, D. (2022). From Small Peptides to Large Proteins against Alzheimer'sDisease. Biomolecules, 12(10). https://doi.org/10.3390/biom12101344
Picone P, et al. From Small Peptides to Large Proteins Against Alzheimer'sDisease. Biomolecules. 2022 Sep 22;12(10) PubMed PMID: 36291553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From Small Peptides to Large Proteins against Alzheimer'sDisease. AU - Picone,Pasquale, AU - Sanfilippo,Tiziana, AU - Vasto,Sonya, AU - Baldassano,Sara, AU - Guggino,Rossella, AU - Nuzzo,Domenico, AU - Bulone,Donatella, AU - San Biagio,Pier Luigi, AU - Muscolino,Emanuela, AU - Monastero,Roberto, AU - Dispenza,Clelia, AU - Giacomazza,Daniela, Y1 - 2022/09/22/ PY - 2022/07/14/received PY - 2022/09/15/revised PY - 2022/09/17/accepted PY - 2022/10/27/entrez PY - 2022/10/28/pubmed PY - 2022/10/29/medline KW - Alzheimer’s disease KW - Tau protein KW - amyloid-beta protein: amyloid fibrillation KW - neurofibrillary tangles JF - Biomolecules JO - Biomolecules VL - 12 IS - 10 N2 - Alzheimer's disease (AD) is the most common neurodegenerative disorder in the elderly. The two cardinal neuropathological hallmarks of AD are the senile plaques, which are extracellular deposits mainly constituted by beta-amyloids, and neurofibrillary tangles formed by abnormally phosphorylated Tau (p-Tau) located in the cytoplasm of neurons. Although the research has made relevant progress in the management of the disease, the treatment is still lacking. Only symptomatic medications exist for the disease, and, in the meantime, laboratories worldwide are investigating disease-modifying treatments for AD. In the present review, results centered on the use of peptides of different sizes involved in AD are presented. SN - 2218-273X UR - https://www.unboundmedicine.com/medline/citation/36291553/From_Small_Peptides_to_Large_Proteins_against_Alzheimer'sDisease_ DB - PRIME DP - Unbound Medicine ER -