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Dietary influences on the antiparkinsonian response to levodopa.
Arch Neurol. 1987 Oct; 44(10):1003-5.AN

Abstract

The ability of dietary factors to modify the response to levodopa was evaluated in six patients with idiopathic Parkinson's disease who manifested fluctuations in motor performance. The single oral administration of a high-protein formula substantially elevated plasma large neutral amino acid levels, and prematurely terminated the antiparkinsonian response to levodopa/carbidopa. In contrast, during oral or intravenous administration of levodopa, the ingestion of diets meeting the recommended daily allowance (RDA) for protein had no significant effect on plasma levodopa or large neutral amino acid levels or variance, nor on parkinsonian scores or variance. The results suggest that while protein intake in excess of the RDA can diminish the antiparkinsonian response to orally administered levodopa/carbidopa in patients with advanced disease, diets adhering to RDA protein guidelines have no clinically appreciable effect.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3632369

Citation

Juncos, J L., et al. "Dietary Influences On the Antiparkinsonian Response to Levodopa." Archives of Neurology, vol. 44, no. 10, 1987, pp. 1003-5.
Juncos JL, Fabbrini G, Mouradian MM, et al. Dietary influences on the antiparkinsonian response to levodopa. Arch Neurol. 1987;44(10):1003-5.
Juncos, J. L., Fabbrini, G., Mouradian, M. M., Serrati, C., & Chase, T. N. (1987). Dietary influences on the antiparkinsonian response to levodopa. Archives of Neurology, 44(10), 1003-5.
Juncos JL, et al. Dietary Influences On the Antiparkinsonian Response to Levodopa. Arch Neurol. 1987;44(10):1003-5. PubMed PMID: 3632369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary influences on the antiparkinsonian response to levodopa. AU - Juncos,J L, AU - Fabbrini,G, AU - Mouradian,M M, AU - Serrati,C, AU - Chase,T N, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 1003 EP - 5 JF - Archives of neurology JO - Arch Neurol VL - 44 IS - 10 N2 - The ability of dietary factors to modify the response to levodopa was evaluated in six patients with idiopathic Parkinson's disease who manifested fluctuations in motor performance. The single oral administration of a high-protein formula substantially elevated plasma large neutral amino acid levels, and prematurely terminated the antiparkinsonian response to levodopa/carbidopa. In contrast, during oral or intravenous administration of levodopa, the ingestion of diets meeting the recommended daily allowance (RDA) for protein had no significant effect on plasma levodopa or large neutral amino acid levels or variance, nor on parkinsonian scores or variance. The results suggest that while protein intake in excess of the RDA can diminish the antiparkinsonian response to orally administered levodopa/carbidopa in patients with advanced disease, diets adhering to RDA protein guidelines have no clinically appreciable effect. SN - 0003-9942 UR - https://www.unboundmedicine.com/medline/citation/3632369/Dietary_influences_on_the_antiparkinsonian_response_to_levodopa_ L2 - https://jamanetwork.com/journals/jamaneurology/fullarticle/vol/44/pg/1003 DB - PRIME DP - Unbound Medicine ER -