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Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol.
Biomed Biochim Acta. 1987; 46(4):267-70.BB

Abstract

Repeated administration of pentylenetetrazol (PTZ) once every 48 h in behaviourally active threshold and suprathreshold doses induces a marked enhancement of seizure behaviour (kindling phenomenon). In contrast, PTZ in initially subconvulsive doses failed to elicit convulsions more complex than stage 1 seizures. With 40 mg/kg PTZ i.p. kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left. The mean stage 4 dose of PTZ is 40 mg/kg in kindled and 75 mg/kg in non-kindled rats.

Authors

Schmidt J
No affiliation info available

MeSH

AnimalsDose-Response Relationship, DrugFemaleKindling, NeurologicPentylenetetrazoleRatsRats, Inbred StrainsSeizures

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3632650

Citation

Schmidt, J. "Changes in Seizure Susceptibility in Rats Following Chronic Administration of Pentylenetetrazol." Biomedica Biochimica Acta, vol. 46, no. 4, 1987, pp. 267-70.
Schmidt J. Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol. Biomed Biochim Acta. 1987;46(4):267-70.
Schmidt, J. (1987). Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol. Biomedica Biochimica Acta, 46(4), 267-70.
Schmidt J. Changes in Seizure Susceptibility in Rats Following Chronic Administration of Pentylenetetrazol. Biomed Biochim Acta. 1987;46(4):267-70. PubMed PMID: 3632650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in seizure susceptibility in rats following chronic administration of pentylenetetrazol. A1 - Schmidt,J, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 267 EP - 70 JF - Biomedica biochimica acta JO - Biomed Biochim Acta VL - 46 IS - 4 N2 - Repeated administration of pentylenetetrazol (PTZ) once every 48 h in behaviourally active threshold and suprathreshold doses induces a marked enhancement of seizure behaviour (kindling phenomenon). In contrast, PTZ in initially subconvulsive doses failed to elicit convulsions more complex than stage 1 seizures. With 40 mg/kg PTZ i.p. kindled rats show in the fully kindled state a marked shift of the dose-response curve for PTZ-seizures to the left. The mean stage 4 dose of PTZ is 40 mg/kg in kindled and 75 mg/kg in non-kindled rats. SN - 0232-766X UR - https://www.unboundmedicine.com/medline/citation/3632650/Changes_in_seizure_susceptibility_in_rats_following_chronic_administration_of_pentylenetetrazol_ DB - PRIME DP - Unbound Medicine ER -