Tags

Type your tag names separated by a space and hit enter

National Monkeypox Surveillance, Central African Republic, 2001-2021.
Emerg Infect Dis. 2022 12; 28(12):2435-2445.EI

Abstract

We analyzed monkeypox disease surveillance in Central African Republic (CAR) during 2001-2021. Surveillance data show 95 suspected outbreaks, 40 of which were confirmed as monkeypox, comprising 99 confirmed and 61 suspected monkeypox cases. After 2018, CAR's annual rate of confirmed outbreaks increased, and 65% of outbreaks occurred in 2 forested regions bordering the Democratic Republic of the Congo. The median patient age for confirmed cases was 15.5 years. The overall case-fatality ratio was 7.5% (12/160) for confirmed and suspected cases, 9.6% (8/83) for children <16 years of age. Decreasing cross-protective immunity from smallpox vaccination and recent ecologic alterations likely contribute to increased monkeypox outbreaks in Central Africa. High fatality rates associated with monkeypox virus clade I also are a local and international concern. Ongoing investigations of zoonotic sources and environmental changes that increase human exposure could inform practices to prevent monkeypox expansion into local communities and beyond endemic areas.

Links

PMC Free PDF

Authors

Besombes C
No affiliation info available
Mbrenga F
No affiliation info available
Schaeffer L
No affiliation info available
Malaka C
No affiliation info available
Gonofio E
No affiliation info available
Landier J
No affiliation info available
Vickos U
No affiliation info available
Konamna X
No affiliation info available
Selekon B
No affiliation info available
Dankpea JN
No affiliation info available
Von Platen C
No affiliation info available
Houndjahoue FG
No affiliation info available
Ouaïmon DS
No affiliation info available
Hassanin A
No affiliation info available
Berthet N
No affiliation info available
Manuguerra JC
No affiliation info available
Gessain A
No affiliation info available
Fontanet A
No affiliation info available
Nakouné-Yandoko E
No affiliation info available

MeSH

ChildHumansAdolescentMonkeypoxCentral African RepublicMonkeypox virusDisease OutbreaksAfrica, Central

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

36328951

Citation

Besombes, Camille, et al. "National Monkeypox Surveillance, Central African Republic, 2001-2021." Emerging Infectious Diseases, vol. 28, no. 12, 2022, pp. 2435-2445.
Besombes C, Mbrenga F, Schaeffer L, et al. National Monkeypox Surveillance, Central African Republic, 2001-2021. Emerg Infect Dis. 2022;28(12):2435-2445.
Besombes, C., Mbrenga, F., Schaeffer, L., Malaka, C., Gonofio, E., Landier, J., Vickos, U., Konamna, X., Selekon, B., Dankpea, J. N., Von Platen, C., Houndjahoue, F. G., Ouaïmon, D. S., Hassanin, A., Berthet, N., Manuguerra, J. C., Gessain, A., Fontanet, A., & Nakouné-Yandoko, E. (2022). National Monkeypox Surveillance, Central African Republic, 2001-2021. Emerging Infectious Diseases, 28(12), 2435-2445. https://doi.org/10.3201/eid2812.220897
Besombes C, et al. National Monkeypox Surveillance, Central African Republic, 2001-2021. Emerg Infect Dis. 2022;28(12):2435-2445. PubMed PMID: 36328951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - National Monkeypox Surveillance, Central African Republic, 2001-2021. AU - Besombes,Camille, AU - Mbrenga,Festus, AU - Schaeffer,Laura, AU - Malaka,Christian, AU - Gonofio,Ella, AU - Landier,Jordi, AU - Vickos,Ulrich, AU - Konamna,Xavier, AU - Selekon,Benjamin, AU - Dankpea,Joella Namsenei, AU - Von Platen,Cassandre, AU - Houndjahoue,Franck Gislain, AU - Ouaïmon,Daniel Sylver, AU - Hassanin,Alexandre, AU - Berthet,Nicolas, AU - Manuguerra,Jean-Claude, AU - Gessain,Antoine, AU - Fontanet,Arnaud, AU - Nakouné-Yandoko,Emmanuel, Y1 - 2022/11/03/ PY - 2022/11/4/pubmed PY - 2022/11/24/medline PY - 2022/11/3/entrez KW - Central Africa KW - Central African Republic KW - emerging infectious diseases KW - monkeypox KW - monkeypox virus KW - national surveillance KW - outbreak investigation KW - viruses KW - zoonoses SP - 2435 EP - 2445 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 28 IS - 12 N2 - We analyzed monkeypox disease surveillance in Central African Republic (CAR) during 2001-2021. Surveillance data show 95 suspected outbreaks, 40 of which were confirmed as monkeypox, comprising 99 confirmed and 61 suspected monkeypox cases. After 2018, CAR's annual rate of confirmed outbreaks increased, and 65% of outbreaks occurred in 2 forested regions bordering the Democratic Republic of the Congo. The median patient age for confirmed cases was 15.5 years. The overall case-fatality ratio was 7.5% (12/160) for confirmed and suspected cases, 9.6% (8/83) for children <16 years of age. Decreasing cross-protective immunity from smallpox vaccination and recent ecologic alterations likely contribute to increased monkeypox outbreaks in Central Africa. High fatality rates associated with monkeypox virus clade I also are a local and international concern. Ongoing investigations of zoonotic sources and environmental changes that increase human exposure could inform practices to prevent monkeypox expansion into local communities and beyond endemic areas. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/36328951/National_Monkeypox_Surveillance_Central_African_Republic_2001_2021_ DB - PRIME DP - Unbound Medicine ER -