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Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations.
Pharmaceutics. 2022 Nov 02; 14(11)P

Abstract

Labetalol is a drug that exhibits both alpha and beta-adrenergic receptor-blocking properties. The American Heart Association/American Stroke Association (AHA/ASA) has recommended labetalol as an initial treatment option for the management of severe hypertension. The physiologically based pharmacokinetic (PBPK) model is an in silico approach to determining the pharmacokinetics (PK) of a drug by incorporating blood flow and tissue composition of the organs. This study was conducted to evaluate the primary reasons for the difference in PK after intravenous (IV) and oral administration in healthy and diseased (renal and hepatic) populations. A comprehensive literature search was done using two databases, PubMed and Google Scholar. Various PK parameters were screened for the development of the PBPK model utilizing a population-based PK-Sim simulator. Simulations were performed after creating building blocks firstly in healthy individuals and then in diseased patients after IV and oral administration. The disposition of labetalol after IV and oral administration occurring in patients with the hepatic and renal disease was predicted. The model was evaluated by calculating the Robs/pred ratio and average fold error (AFE), which was in the two-fold error range. Moreover, Box-whisker plots were made to compare the overall concentration of the drug in the body at various stages of disease severity. The presented model provides useful quantitative estimates of drug dosing in patients fighting against severe chronic diseases.

Authors+Show Affiliations

Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan.Section of Pharmaceutics, University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore 54000, Pakistan.Institute for Advanced Biosciences (IAB), CNRS UMR5309, INSERM U1209, Grenoble Alpes University, 38700 La Tronche, France.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36365181

Citation

Hafsa, Hafsa, et al. "Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations." Pharmaceutics, vol. 14, no. 11, 2022.
Hafsa H, Zamir A, Rasool MF, et al. Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations. Pharmaceutics. 2022;14(11).
Hafsa, H., Zamir, A., Rasool, M. F., Imran, I., Saeed, H., Ahmad, T., Alsanea, S., Alshamrani, A. A., Alruwaili, A. H., & Alqahtani, F. (2022). Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations. Pharmaceutics, 14(11). https://doi.org/10.3390/pharmaceutics14112362
Hafsa H, et al. Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations. Pharmaceutics. 2022 Nov 2;14(11) PubMed PMID: 36365181.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and Evaluation of a Physiologically Based Pharmacokinetic Model of Labetalol in Healthy and Diseased Populations. AU - Hafsa,Hafsa, AU - Zamir,Ammara, AU - Rasool,Muhammad Fawad, AU - Imran,Imran, AU - Saeed,Hamid, AU - Ahmad,Tanveer, AU - Alsanea,Sary, AU - Alshamrani,Ali A, AU - Alruwaili,Abdullah H, AU - Alqahtani,Faleh, Y1 - 2022/11/02/ PY - 2022/09/23/received PY - 2022/10/26/revised PY - 2022/10/31/accepted PY - 2022/11/11/entrez PY - 2022/11/12/pubmed PY - 2022/11/12/medline KW - PBPK KW - beta blocker KW - drug-drug interaction KW - drug-food interaction KW - hepatic disease KW - labetalol KW - pharmacokinetics KW - renal failure JF - Pharmaceutics JO - Pharmaceutics VL - 14 IS - 11 N2 - Labetalol is a drug that exhibits both alpha and beta-adrenergic receptor-blocking properties. The American Heart Association/American Stroke Association (AHA/ASA) has recommended labetalol as an initial treatment option for the management of severe hypertension. The physiologically based pharmacokinetic (PBPK) model is an in silico approach to determining the pharmacokinetics (PK) of a drug by incorporating blood flow and tissue composition of the organs. This study was conducted to evaluate the primary reasons for the difference in PK after intravenous (IV) and oral administration in healthy and diseased (renal and hepatic) populations. A comprehensive literature search was done using two databases, PubMed and Google Scholar. Various PK parameters were screened for the development of the PBPK model utilizing a population-based PK-Sim simulator. Simulations were performed after creating building blocks firstly in healthy individuals and then in diseased patients after IV and oral administration. The disposition of labetalol after IV and oral administration occurring in patients with the hepatic and renal disease was predicted. The model was evaluated by calculating the Robs/pred ratio and average fold error (AFE), which was in the two-fold error range. Moreover, Box-whisker plots were made to compare the overall concentration of the drug in the body at various stages of disease severity. The presented model provides useful quantitative estimates of drug dosing in patients fighting against severe chronic diseases. SN - 1999-4923 UR - https://www.unboundmedicine.com/medline/citation/36365181/Development_and_Evaluation_of_a_Physiologically_Based_Pharmacokinetic_Model_of_Labetalol_in_Healthy_and_Diseased_Populations. DB - PRIME DP - Unbound Medicine ER -
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