Tags

Type your tag names separated by a space and hit enter

Formation of antibody against Mycobacterium leprae antigen 7 in armadillos.
J Med Microbiol. 1978 Nov; 11(4):525-35.JM

Abstract

A radioimmunoassay developed to measure antibody against Mycobacterium leprae antigen 7 in man was applied to the nine-banded armadillo (Dasypus novemcinctus). Normal armadillo sera had low but significant antibody activity in the test. Fourteen of 17 armadillos with systemic mycobacterial infection after inoculation with M. leprae showed increased antibody activity in the assay, and in some instances the activity was higher than in a pool of sera from patients with lepromatous leprosy. Crossed immunoelectrophoresis with armadillo serum in the intermediate gel revealed antibodies against five distinct antigenic components of M. leprae. Development of systemic mycobacterial infection after inoculation with M. leprae is thus associated with a distinct humoral immune response. The use of radioimmunosassay for selection of animals for inoculation and for following the development of the infection is discussed.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

364069

Citation

Harboe, M, et al. "Formation of Antibody Against Mycobacterium Leprae Antigen 7 in Armadillos." Journal of Medical Microbiology, vol. 11, no. 4, 1978, pp. 525-35.
Harboe M, Closs O, Rees RJ, et al. Formation of antibody against Mycobacterium leprae antigen 7 in armadillos. J Med Microbiol. 1978;11(4):525-35.
Harboe, M., Closs, O., Rees, R. J., & Walsh, G. P. (1978). Formation of antibody against Mycobacterium leprae antigen 7 in armadillos. Journal of Medical Microbiology, 11(4), 525-35.
Harboe M, et al. Formation of Antibody Against Mycobacterium Leprae Antigen 7 in Armadillos. J Med Microbiol. 1978;11(4):525-35. PubMed PMID: 364069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formation of antibody against Mycobacterium leprae antigen 7 in armadillos. AU - Harboe,M, AU - Closs,O, AU - Rees,R J, AU - Walsh,G P, PY - 1978/11/1/pubmed PY - 1978/11/1/medline PY - 1978/11/1/entrez SP - 525 EP - 35 JF - Journal of medical microbiology JO - J Med Microbiol VL - 11 IS - 4 N2 - A radioimmunoassay developed to measure antibody against Mycobacterium leprae antigen 7 in man was applied to the nine-banded armadillo (Dasypus novemcinctus). Normal armadillo sera had low but significant antibody activity in the test. Fourteen of 17 armadillos with systemic mycobacterial infection after inoculation with M. leprae showed increased antibody activity in the assay, and in some instances the activity was higher than in a pool of sera from patients with lepromatous leprosy. Crossed immunoelectrophoresis with armadillo serum in the intermediate gel revealed antibodies against five distinct antigenic components of M. leprae. Development of systemic mycobacterial infection after inoculation with M. leprae is thus associated with a distinct humoral immune response. The use of radioimmunosassay for selection of animals for inoculation and for following the development of the infection is discussed. SN - 0022-2615 UR - https://www.unboundmedicine.com/medline/citation/364069/Formation_of_antibody_against_Mycobacterium_leprae_antigen_7_in_armadillos_ L2 - http://jmm.microbiologyresearch.org/pubmed/content/journal/jmm/10.1099/00222615-11-4-525 DB - PRIME DP - Unbound Medicine ER -