TY - JOUR T1 - Identification of Uric Acid Crystals Accumulation in Human and Animal Tissues Using Combined Morphological and Raman Spectroscopy Analysis. AU - Soare,Teodoru, AU - Iordache,Ana Maria, AU - Nicolae,George, AU - Iordache,Stefan-Marian, AU - Baciu,Cosmin, AU - Marinescu,Silviu, AU - Rizac,Raluca Ioana, AU - Militaru,Manuella, Y1 - 2022/11/11/ PY - 2022/09/20/received PY - 2022/10/20/revised PY - 2022/11/08/accepted PY - 2022/11/26/entrez PY - 2022/11/27/pubmed PY - 2022/11/27/medline KW - Raman spectroscopy KW - comparative pathology KW - crystals KW - gout KW - human KW - poultry KW - reptiles KW - uric acid JF - Diagnostics (Basel, Switzerland) JO - Diagnostics (Basel) VL - 12 IS - 11 N2 - Gout is a metabolic condition, common to animals and humans, issuing from the excessive accumulation of end products of proteins degradation. In this study, histopathological and cytological examinations, combined with Raman spectroscopy, have been performed to investigate tissue samples from reptiles, chickens, and humans, presenting lesions produced by uric acid accumulation. As a result of classic processing and staining techniques commonly used in the anatomopathological diagnosis, uric acid crystals lose their structural characteristics, thus making difficult a precise diagnostic. Therefore, complementary diagnostic methods, such as Raman spectroscopy, are needed. This study compares from several perspectives the above mentioned diagnostic methods, concluding that Raman spectroscopy provides highlights in the diagnosis of gout in humans and animals, also adding useful information to differential diagnosis of lesions. SN - 2075-4418 UR - https://www.unboundmedicine.com/medline/citation/36428822/Identification_of_Uric_Acid_Crystals_Accumulation_in_Human_and_Animal_Tissues_Using_Combined_Morphological_and_Raman_Spectroscopy_Analysis_ DB - PRIME DP - Unbound Medicine ER -