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Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set.
Ann Hum Biol. 2022 Dec; 49(7-8):361-366.AH

Abstract

BACKGROUND

The analysis of Y chromosomal genetic markers is of great significance in human genetic fields related to male individuals. The Han nationality is the most populous ethnic group. It is critical to investigate the Y-chromosome short tandem repeat (Y-STR) genetic informativeness of Han nationalities in different Chinese regions in order to gain a comprehensive understanding of their paternal genetic relationships and origin.

AIM

To assess the allelic and haplotypic polymorphisms of the novel AGCU Y SUPP STR amplification system containing seven Y-STRs in the maximal dataset of the Y-STR Haplotype Reference Database (YHRD) and 17 newly included Y-STRs, and explore the genetic relationships among the Shaanxi Han population and 12 reference populations from China.

SUBJECTS AND METHODS

A total sample of 220 Han male subjects were obtained from the Shaanxi Province, China, and genotyped by the novel AGCU Y SUPP STR amplification system. Multiplex population genetic analyses derived from the same 16 Y-STR loci were carried out among the Shaanxi Han population and 12 reference populations from China.

RESULTS

The gene diversities (GD) ranged from the maximum value of 0.9609 (DYS385a,b) to the minimum value of 0.5441 (DYS531). Besides, 217 distinct haplotypes were detected wholly in 220 individuals, of which 214 (98.62%) were exclusive. The entire haplotype diversity (HD) and discrimination capacity (DC) were 0.9999 and 0.9864, respectively, while the haplotype match probability (HMP) was 0.0045. Among the reference populations, the obtained results of population genetic analyses revealed that the Shaanxi Han population had the largest genetic distance with the Guangxi Yao group, but the smallest genetic distance with the Hunan Tujia group.

CONCLUSIONS

These Y-STR loci in the AGCU Y SUPP STR amplification system were of high genetic polymorphisms and the amplification system could be used as a prospective complementary tool for forensic application and paternal genetics in the Shaanxi Han population.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China.

Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, China. Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

MeSH

HumansMaleChinaChromosomes, Human, YEast Asian PeopleGenetics, PopulationHaplotypesMicrosatellite RepeatsPolymorphism, GeneticProspective Studies

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36437608

Citation

Xu, Hui, et al. "Allelic and Haplotypic Polymorphisms and Paternal Genetic Analysis of Chinese Shaanxi Han Population Utilizing a Multiplex Y-STR Set." Annals of Human Biology, vol. 49, no. 7-8, 2022, pp. 361-366.

Xu H, Zhao M, Mei S, et al. Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set. Ann Hum Biol. 2022;49(7-8):361-366.

Xu, H., Zhao, M., Mei, S., Zhang, Y., Cai, M., Lei, F., & Zhu, B. (2022). Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set. Annals of Human Biology, 49(7-8), 361-366. https://doi.org/10.1080/03014460.2022.2152487

Xu H, et al. Allelic and Haplotypic Polymorphisms and Paternal Genetic Analysis of Chinese Shaanxi Han Population Utilizing a Multiplex Y-STR Set. Ann Hum Biol. 2022;49(7-8):361-366. PubMed PMID: 36437608.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Allelic and haplotypic polymorphisms and paternal genetic analysis of Chinese Shaanxi Han population utilizing a multiplex Y-STR set. AU - Xu,Hui, AU - Zhao,Ming, AU - Mei,Shuyan, AU - Zhang,Yunying, AU - Cai,Meiming, AU - Lei,Fanzhang, AU - Zhu,Bofeng, Y1 - 2022/12/27/ PY - 2022/11/29/pubmed PY - 2022/11/29/medline PY - 2022/11/28/entrez KW - AGCU Y SUPP STR amplification system KW - Shaanxi Han population KW - Y-STR KW - genetic polymorphism KW - haplotype diversity SP - 361 EP - 366 JF - Annals of human biology JO - Ann Hum Biol VL - 49 IS - 7-8 N2 - BACKGROUND: The analysis of Y chromosomal genetic markers is of great significance in human genetic fields related to male individuals. The Han nationality is the most populous ethnic group. It is critical to investigate the Y-chromosome short tandem repeat (Y-STR) genetic informativeness of Han nationalities in different Chinese regions in order to gain a comprehensive understanding of their paternal genetic relationships and origin. AIM: To assess the allelic and haplotypic polymorphisms of the novel AGCU Y SUPP STR amplification system containing seven Y-STRs in the maximal dataset of the Y-STR Haplotype Reference Database (YHRD) and 17 newly included Y-STRs, and explore the genetic relationships among the Shaanxi Han population and 12 reference populations from China. SUBJECTS AND METHODS: A total sample of 220 Han male subjects were obtained from the Shaanxi Province, China, and genotyped by the novel AGCU Y SUPP STR amplification system. Multiplex population genetic analyses derived from the same 16 Y-STR loci were carried out among the Shaanxi Han population and 12 reference populations from China. RESULTS: The gene diversities (GD) ranged from the maximum value of 0.9609 (DYS385a,b) to the minimum value of 0.5441 (DYS531). Besides, 217 distinct haplotypes were detected wholly in 220 individuals, of which 214 (98.62%) were exclusive. The entire haplotype diversity (HD) and discrimination capacity (DC) were 0.9999 and 0.9864, respectively, while the haplotype match probability (HMP) was 0.0045. Among the reference populations, the obtained results of population genetic analyses revealed that the Shaanxi Han population had the largest genetic distance with the Guangxi Yao group, but the smallest genetic distance with the Hunan Tujia group. CONCLUSIONS: These Y-STR loci in the AGCU Y SUPP STR amplification system were of high genetic polymorphisms and the amplification system could be used as a prospective complementary tool for forensic application and paternal genetics in the Shaanxi Han population. SN - 1464-5033 UR - https://www.unboundmedicine.com/medline/citation/36437608/Allelic_and_haplotypic_polymorphisms_and_paternal_genetic_analysis_of_Chinese_Shaanxi_Han_population_utilizing_a_multiplex_Y_STR_set_ DB - PRIME DP - Unbound Medicine ER -