Tags

Type your tag names separated by a space and hit enter

[A systematic analysis of neurobiological roles of lithium].
Zh Nevrol Psikhiatr Im S S Korsakova. 2022; 122(11):17-23.ZN

Abstract

Lithium salts have been the mainstay of treatment for bipolar disorder for more than 50 years, since the FDA approved the treatment in 1970. Molecular mechanisms of lithium's action include inhibition of glycogen synthase kinase 3 beta and inositol monophosphatase, resulting in induction of brain-derived neurotrophic factor, antiapoptotic proteins, deprivation of calcium-induced apoptosis. Recent findings suggest autophagy regulation as a possible mechanism of lithium neuroprotective action. Moreover, lithium treatment has been reported to decrease accumulation of various pathological proteins including phosphorylated tau and amyloid-B. Also, telomeres length and telomerase activity are suggested to be upregulated by lithium. Clinical applications of lithium treatment include various neurodegenerative diseases, primarily Alzheimer disease, with increasing importance given to the use of lithium microdoses. Chemoreactome screening is used to find more safe and effective lithium compounds.

Authors+Show Affiliations

Ivanovo State Medical Academy, Ivanovo, Russia.Federal Research Center «Informatics and Management», Moscow, Russia.Federal Research Center «Informatics and Management», Moscow, Russia.Ivanovo State Medical Academy, Ivanovo, Russia.Ivanovo State Medical Academy, Ivanovo, Russia.

Pub Type(s)

English Abstract
Journal Article

Language

rus

PubMed ID

36440772

Citation

Gogoleva, I V., et al. "[A Systematic Analysis of Neurobiological Roles of Lithium]." Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, vol. 122, no. 11, 2022, pp. 17-23.
Gogoleva IV, Gromova OA, Torshin IY, et al. [A systematic analysis of neurobiological roles of lithium]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(11):17-23.
Gogoleva, I. V., Gromova, O. A., Torshin, I. Y., Grishina, T. R., & Pronin, A. V. (2022). [A systematic analysis of neurobiological roles of lithium]. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, 122(11), 17-23. https://doi.org/10.17116/jnevro202212211117
Gogoleva IV, et al. [A Systematic Analysis of Neurobiological Roles of Lithium]. Zh Nevrol Psikhiatr Im S S Korsakova. 2022;122(11):17-23. PubMed PMID: 36440772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A systematic analysis of neurobiological roles of lithium]. AU - Gogoleva,I V, AU - Gromova,O A, AU - Torshin,I Y, AU - Grishina,T R, AU - Pronin,A V, PY - 2022/11/28/entrez PY - 2022/11/29/pubmed PY - 2022/11/30/medline KW - Alzheimer’s disease KW - autophagy KW - chemoinformatics KW - lithium therapy KW - neurocytology KW - neuroprotection KW - telomerase KW - toxicology SP - 17 EP - 23 JF - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova JO - Zh Nevrol Psikhiatr Im S S Korsakova VL - 122 IS - 11 N2 - Lithium salts have been the mainstay of treatment for bipolar disorder for more than 50 years, since the FDA approved the treatment in 1970. Molecular mechanisms of lithium's action include inhibition of glycogen synthase kinase 3 beta and inositol monophosphatase, resulting in induction of brain-derived neurotrophic factor, antiapoptotic proteins, deprivation of calcium-induced apoptosis. Recent findings suggest autophagy regulation as a possible mechanism of lithium neuroprotective action. Moreover, lithium treatment has been reported to decrease accumulation of various pathological proteins including phosphorylated tau and amyloid-B. Also, telomeres length and telomerase activity are suggested to be upregulated by lithium. Clinical applications of lithium treatment include various neurodegenerative diseases, primarily Alzheimer disease, with increasing importance given to the use of lithium microdoses. Chemoreactome screening is used to find more safe and effective lithium compounds. SN - 1997-7298 UR - https://www.unboundmedicine.com/medline/citation/36440772/[A_systematic_analysis_of_neurobiological_roles_of_lithium]_ DB - PRIME DP - Unbound Medicine ER -