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The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors.
Hear Res. 1987; 26(1):117-25.HR

Abstract

The Ca2+ concentrations in cochlear perilymph and endolymph of the guinea pig were measured with double-barreled Ca2+-selective microelectrodes and showed 1.76 +/- 0.74 X 10(-3) M and 2.20 +/- 0.19 X 10(-5) M, respectively. The electrochemical potential gradient for Ca2+ between perilymph and endolymph was 23.2 mV and the existence of an active transport mechanism from the former to the latter was suggested. Vanadate given perilymphatically decreased the Ca2+ concentration in endolymph with a slight elevation of the endocochlear potential and was suspected of blocking the active transport. The Ca2+ concentration in endolymph was abruptly increased by anoxia or the intravenous administration of 60 mg/kg furosemide and was slightly increased by the intravenous administration of 30 mg/kg furosemide or 100 mg/kg acetazolamide. The endolymphatic pH measured with pH-microelectrodes under various conditions indicates that the mechanism of increase in the Ca2+ concentration is attributed not to the liberation of Ca2+ from the surrounding tissues caused by a fall in pH but to the increased influx of Ca2+ from perilymph due to the depression of the endocochlear potential.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3644819

Citation

Ikeda, K, et al. "The Ca2+ Activity of Cochlear Endolymph of the Guinea Pig and the Effect of Inhibitors." Hearing Research, vol. 26, no. 1, 1987, pp. 117-25.
Ikeda K, Kusakari J, Takasaka T, et al. The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors. Hear Res. 1987;26(1):117-25.
Ikeda, K., Kusakari, J., Takasaka, T., & Saito, Y. (1987). The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors. Hearing Research, 26(1), 117-25.
Ikeda K, et al. The Ca2+ Activity of Cochlear Endolymph of the Guinea Pig and the Effect of Inhibitors. Hear Res. 1987;26(1):117-25. PubMed PMID: 3644819.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Ca2+ activity of cochlear endolymph of the guinea pig and the effect of inhibitors. AU - Ikeda,K, AU - Kusakari,J, AU - Takasaka,T, AU - Saito,Y, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 117 EP - 25 JF - Hearing research JO - Hear Res VL - 26 IS - 1 N2 - The Ca2+ concentrations in cochlear perilymph and endolymph of the guinea pig were measured with double-barreled Ca2+-selective microelectrodes and showed 1.76 +/- 0.74 X 10(-3) M and 2.20 +/- 0.19 X 10(-5) M, respectively. The electrochemical potential gradient for Ca2+ between perilymph and endolymph was 23.2 mV and the existence of an active transport mechanism from the former to the latter was suggested. Vanadate given perilymphatically decreased the Ca2+ concentration in endolymph with a slight elevation of the endocochlear potential and was suspected of blocking the active transport. The Ca2+ concentration in endolymph was abruptly increased by anoxia or the intravenous administration of 60 mg/kg furosemide and was slightly increased by the intravenous administration of 30 mg/kg furosemide or 100 mg/kg acetazolamide. The endolymphatic pH measured with pH-microelectrodes under various conditions indicates that the mechanism of increase in the Ca2+ concentration is attributed not to the liberation of Ca2+ from the surrounding tissues caused by a fall in pH but to the increased influx of Ca2+ from perilymph due to the depression of the endocochlear potential. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/3644819/The_Ca2+_activity_of_cochlear_endolymph_of_the_guinea_pig_and_the_effect_of_inhibitors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0378-5955(87)90040-2 DB - PRIME DP - Unbound Medicine ER -