Abstract
BACKGROUND
Atopic dermatitis (AD), a skin disease burden worldwide, is a complex, multifactorial, chronic inflammatory disease. Prevalence of AD is increasing in developing countries and identifying the causative allergens is a major challenge. Aeroallergens are shown to aggravate atopic dermatitis.
PURPOSE
Explore the prevalence of aeroallergens sensitization in patients with AD and its possible relation with AD severity.
METHODS
Cross-sectional study of 132 patients diagnosed to have atopic dermatitis. Atopy was detected by serum specific IgE to a panel of the most encountered aeroallergens.
RESULTS
From the 132 patients, elevated specific IgE was detected in 72.7 % from which 59.1 % were mild and 86.4 % are moderate/severe as well as 15.9 % are mono-sensitized and 54.5 % are poly-sensitized with poly-sensitization being more in severe cases compared to mild cases (68.2 % vs 4.5 %). Regarding specific IgE to different aeroallergens, the most prevalent were Dermatophagoides pteronyssinus (50 %), followed by Dermatophagoides farinae (34.1 %), Birch pollen (20.5 %), cat epithelium (18.2 %) Regweed (15.9 %), and Cockroach (9.1 %). However, moderate to severe cases were more sensitized to candida (p = 0.012), mix grass pollen (p = 0.002), ragweed (0.00), mite (p = 0.037) and cat epithelium (p = 0.007).
CONCLUSION
Dermatophagoides pteronyssinus, Dermatophagoides farinae, Birch pollen, cat epithelium Regweed and Cockroach are the most frequent sensitizing aeroallergens in atopic dermatitis.
TY - JOUR
T1 - Prevalence of common sensitizing aeroallergens in patients with atopic dermatitis.
AU - Amin,Mariam M,
AU - Elkady,Hossam M,
Y1 - 2022/12/02/
PY - 2022/06/20/received
PY - 2022/10/26/revised
PY - 2022/11/12/accepted
PY - 2022/12/6/pubmed
PY - 2023/1/17/medline
PY - 2022/12/5/entrez
KW - Aeroallergens
KW - Atopic dermatitis
KW - Eczema
KW - Specific IgE
SP - 156087
EP - 156087
JF - Cytokine
JO - Cytokine
VL - 162
N2 - BACKGROUND: Atopic dermatitis (AD), a skin disease burden worldwide, is a complex, multifactorial, chronic inflammatory disease. Prevalence of AD is increasing in developing countries and identifying the causative allergens is a major challenge. Aeroallergens are shown to aggravate atopic dermatitis. PURPOSE: Explore the prevalence of aeroallergens sensitization in patients with AD and its possible relation with AD severity. METHODS: Cross-sectional study of 132 patients diagnosed to have atopic dermatitis. Atopy was detected by serum specific IgE to a panel of the most encountered aeroallergens. RESULTS: From the 132 patients, elevated specific IgE was detected in 72.7 % from which 59.1 % were mild and 86.4 % are moderate/severe as well as 15.9 % are mono-sensitized and 54.5 % are poly-sensitized with poly-sensitization being more in severe cases compared to mild cases (68.2 % vs 4.5 %). Regarding specific IgE to different aeroallergens, the most prevalent were Dermatophagoides pteronyssinus (50 %), followed by Dermatophagoides farinae (34.1 %), Birch pollen (20.5 %), cat epithelium (18.2 %) Regweed (15.9 %), and Cockroach (9.1 %). However, moderate to severe cases were more sensitized to candida (p = 0.012), mix grass pollen (p = 0.002), ragweed (0.00), mite (p = 0.037) and cat epithelium (p = 0.007). CONCLUSION: Dermatophagoides pteronyssinus, Dermatophagoides farinae, Birch pollen, cat epithelium Regweed and Cockroach are the most frequent sensitizing aeroallergens in atopic dermatitis.
SN - 1096-0023
UR - https://www.unboundmedicine.com/medline/citation/36470066/Prevalence_of_common_sensitizing_aeroallergens_in_patients_with_atopic_dermatitis_
DB - PRIME
DP - Unbound Medicine
ER -
