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Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents.
J Ethnopharmacol. 2023 Mar 01; 303:116036.JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Aniba canelilla, distributed in the Amazon region, stands out for its diverse economic and medicinal applications. Studies of the A. canelilla essential oil and its primary constituent, 1-nitro-2-phenylethane, have confirmed its anti-inflammatory, antinociceptive, anti-hypertensive potential, and anticholinesterase, among other therapeutic activities.

AIM OF THE STUDY

In addition, the present work aims to evaluate the potential of oil and NPE in the learning and memory of rodents.

MATERIAL AND METHODS

The oil was hydrodistilled and analyzed by GC and GC-MS. The learning and memory action in mice was evaluated through the scopolamine-induced cognitive deficit model, followed by behavioral analysis using Morris's water maze paradigm.

RESULTS

Oil provided a yield of 0.5%, and in its chemical composition, 1-nitro-2-phenylethane (NPE) (76.2%) and methyleugenol (19.6%) were identified as primary constituents. Oil fractionation furnished NPE with 99.4%, which was used to evaluate its effects in animal models. Wistar rats were submitted to the mnemonic impairment-scopolamine-induced protocol for 7 days. The oil, NPE, and the positive control donepezil were administered from the 8th to 12th days. Morris water maze results demonstrated that oil and NPE reversed spatial learning and long-term memory similarly induced by muscarinic antagonist scopolamine to donepezil, the positive control.

CONCLUSION

These beneficial effects have led the work to further investigations of the oil and NPE to elucidate their pharmacological mechanism, focusing on the cholinergic pathway of the central nervous system and opening up to the knowledge of other adjacent mechanisms, whose results are still under analysis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

de Campos DL
Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: daniele.dim94@gmail.com.
Queiroz LY
Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: leehyoshitome@gmail.com.
Fontes-Junior EA
Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: efontes@ufpa.br.
Pinheiro BG
Centro de Ciências Biológicas, Universidade do Estado do Pará, 66087-662, Belém, PA, Brazil. Electronic address: brunogpinheiro1@gmail.com.
da Silva JKR
Programa de Pós-Graduação em Química, Universidade Federal do Pará, 66075-900, Belém, PA, Brazil. Electronic address: joycekellys@ufpa.br.
Maia CSF
Laboratório de Farmacologia da Inflamação e Comportamento, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil. Electronic address: crismaia@ufpa.br.
Maia JGS
Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, 66075-110, Belém, PA, Brazil; Programa de Pós-Graduação em Química, Universidade Federal do Maranhão, 65080-040, São Luís, MA, Brazil. Electronic address: gmaia@ufpa.br.

MeSH

RatsMiceAnimalsOils, VolatileAcetylcholinesteraseRodentiaRats, WistarDonepezilLauraceaeScopolamineMemory DisordersMaze Learning

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36493997

Citation

de Campos, Daniele L., et al. "Aniba Canelilla (Kunth) Mez Essential Oil and Its Primary Constituent, 1-nitro-2-phenylethane, Inhibits Acetylcholinesterase and Reverse Memory Impairment in Rodents." Journal of Ethnopharmacology, vol. 303, 2023, p. 116036.
de Campos DL, Queiroz LY, Fontes-Junior EA, et al. Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents. J Ethnopharmacol. 2023;303:116036.
de Campos, D. L., Queiroz, L. Y., Fontes-Junior, E. A., Pinheiro, B. G., da Silva, J. K. R., Maia, C. S. F., & Maia, J. G. S. (2023). Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents. Journal of Ethnopharmacology, 303, 116036. https://doi.org/10.1016/j.jep.2022.116036
de Campos DL, et al. Aniba Canelilla (Kunth) Mez Essential Oil and Its Primary Constituent, 1-nitro-2-phenylethane, Inhibits Acetylcholinesterase and Reverse Memory Impairment in Rodents. J Ethnopharmacol. 2023 Mar 1;303:116036. PubMed PMID: 36493997.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents. AU - de Campos,Daniele L, AU - Queiroz,Letícia Y, AU - Fontes-Junior,Enéas A, AU - Pinheiro,Bruno G, AU - da Silva,Joyce Kelly R, AU - Maia,Cristiane Socorro F, AU - Maia,José Guilherme S, Y1 - 2022/12/07/ PY - 2022/10/10/received PY - 2022/12/02/revised PY - 2022/12/05/accepted PY - 2022/12/10/pubmed PY - 2022/12/10/medline PY - 2022/12/9/entrez KW - 1-Nitro-2-phenylethane KW - Aniba canelilla essential oil KW - Behavioral analysis KW - Dementia and Alzheimer's disease KW - Learning and memory SP - 116036 EP - 116036 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 303 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Aniba canelilla, distributed in the Amazon region, stands out for its diverse economic and medicinal applications. Studies of the A. canelilla essential oil and its primary constituent, 1-nitro-2-phenylethane, have confirmed its anti-inflammatory, antinociceptive, anti-hypertensive potential, and anticholinesterase, among other therapeutic activities. AIM OF THE STUDY: In addition, the present work aims to evaluate the potential of oil and NPE in the learning and memory of rodents. MATERIAL AND METHODS: The oil was hydrodistilled and analyzed by GC and GC-MS. The learning and memory action in mice was evaluated through the scopolamine-induced cognitive deficit model, followed by behavioral analysis using Morris's water maze paradigm. RESULTS: Oil provided a yield of 0.5%, and in its chemical composition, 1-nitro-2-phenylethane (NPE) (76.2%) and methyleugenol (19.6%) were identified as primary constituents. Oil fractionation furnished NPE with 99.4%, which was used to evaluate its effects in animal models. Wistar rats were submitted to the mnemonic impairment-scopolamine-induced protocol for 7 days. The oil, NPE, and the positive control donepezil were administered from the 8th to 12th days. Morris water maze results demonstrated that oil and NPE reversed spatial learning and long-term memory similarly induced by muscarinic antagonist scopolamine to donepezil, the positive control. CONCLUSION: These beneficial effects have led the work to further investigations of the oil and NPE to elucidate their pharmacological mechanism, focusing on the cholinergic pathway of the central nervous system and opening up to the knowledge of other adjacent mechanisms, whose results are still under analysis. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/36493997/Aniba_canelilla__Kunth__Mez_essential_oil_and_its_primary_constituent_1_nitro_2_phenylethane_inhibits_acetylcholinesterase_and_reverse_memory_impairment_in_rodents_ DB - PRIME DP - Unbound Medicine ER -

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