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Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson's Disease.
Nutrients. 2022 Dec 06; 14(23)N

Abstract

The Mediterranean (MEDI) and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets have been associated with a reduced risk of Parkinson’s disease (PD) diagnosis. However, studies evaluating whether these diets are associated with disease progression in those patients already diagnosed are lacking. The objective of this study was to evaluate whether MIND and MEDI scores were associated with improved patient-reported outcomes. Additionally, we sought to explore which questions on the MIND and MEDI scales were more strongly correlated with PD symptom severity. Data were obtained from the ongoing Modifiable Variables in Parkinsonism study, using patient-reported outcomes in Parkinson’s disease (PRO-PD) as the primary measure for symptom severity, and MIND and MEDI scales for diet score. After adjusting for age, gender, income, and years since diagnosis, for each 1-point increase in the MIND and MEDI scores, PRO-PD scores were 52.9 points lower (95%CI: −66.4, −39.4; p < 0.001) and 25.6 points lower (95%CI: −37.2, −14.0; p < 0.001), respectively (N = 1205). This study suggests MIND and MEDI scores are associated with fewer patient-reported symptoms over time, with each MIND point being twice as strong as a MEDI point in reducing symptom severity. Future dietary intervention trials should consider the MIND diet as a therapeutic strategy for improving long-term PD outcomes.

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Authors+Show Affiliations

Fox DJ
Parkinson Center for Pragmatic Research, Seattle, WA 98133, USA.
Park SJ
Bastyr University Research Institute, Bastyr University, Kenmore, WA 98028, USA.
Mischley LK
Parkinson Center for Pragmatic Research, Seattle, WA 98133, USA. Bastyr University Research Institute, Bastyr University, Kenmore, WA 98028, USA. Translational Bioenergetics Laboratory, Department of Radiology, University of Washington, Seattle, WA 98105, USA .

MeSH

HumansDiet, MediterraneanParkinson DiseaseDisease ProgressionLongitudinal StudiesPatient Reported Outcome Measures

Pub Type(s)

Journal Article

Language

eng

PubMed ID

36501214

Citation

Fox, Devon J., et al. "Comparison of Associations Between MIND and Mediterranean Diet Scores With Patient-Reported Outcomes in Parkinson's Disease." Nutrients, vol. 14, no. 23, 2022.
Fox DJ, Park SJ, Mischley LK. Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson's Disease. Nutrients. 2022;14(23).
Fox, D. J., Park, S. J., & Mischley, L. K. (2022). Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson's Disease. Nutrients, 14(23). https://doi.org/10.3390/nu14235185
Fox DJ, Park SJ, Mischley LK. Comparison of Associations Between MIND and Mediterranean Diet Scores With Patient-Reported Outcomes in Parkinson's Disease. Nutrients. 2022 Dec 6;14(23) PubMed PMID: 36501214.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of Associations between MIND and Mediterranean Diet Scores with Patient-Reported Outcomes in Parkinson's Disease. AU - Fox,Devon J, AU - Park,Sarah JaeHwa, AU - Mischley,Laurie K, Y1 - 2022/12/06/ PY - 2022/10/6/received PY - 2022/11/27/revised PY - 2022/11/30/accepted PY - 2022/12/11/entrez PY - 2022/12/12/pubmed PY - 2022/12/15/medline KW - comparative effectiveness KW - disease modification KW - neuroprotection KW - non-motor symptoms KW - parkinsonism JF - Nutrients JO - Nutrients VL - 14 IS - 23 N2 - The Mediterranean (MEDI) and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets have been associated with a reduced risk of Parkinson’s disease (PD) diagnosis. However, studies evaluating whether these diets are associated with disease progression in those patients already diagnosed are lacking. The objective of this study was to evaluate whether MIND and MEDI scores were associated with improved patient-reported outcomes. Additionally, we sought to explore which questions on the MIND and MEDI scales were more strongly correlated with PD symptom severity. Data were obtained from the ongoing Modifiable Variables in Parkinsonism study, using patient-reported outcomes in Parkinson’s disease (PRO-PD) as the primary measure for symptom severity, and MIND and MEDI scales for diet score. After adjusting for age, gender, income, and years since diagnosis, for each 1-point increase in the MIND and MEDI scores, PRO-PD scores were 52.9 points lower (95%CI: −66.4, −39.4; p < 0.001) and 25.6 points lower (95%CI: −37.2, −14.0; p < 0.001), respectively (N = 1205). This study suggests MIND and MEDI scores are associated with fewer patient-reported symptoms over time, with each MIND point being twice as strong as a MEDI point in reducing symptom severity. Future dietary intervention trials should consider the MIND diet as a therapeutic strategy for improving long-term PD outcomes. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/36501214/Comparison_of_Associations_between_MIND_and_Mediterranean_Diet_Scores_with_Patient_Reported_Outcomes_in_Parkinson's_Disease_ DB - PRIME DP - Unbound Medicine ER -